Synchronous detection and application of volatile pollutant exposure and effect markers in urine

A technology for simultaneous detection of volatile pollutants, used in measuring devices, instruments, scientific instruments, etc., can solve the problems of different detection instruments and analysis methods, and achieve the effect of high cost, large data error, and solvent saving.

Active Publication Date: 2021-12-10
SOUTH CHINA INST OF ENVIRONMENTAL SCI MEP
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  • Application Information

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Problems solved by technology

[0007] In view of the above-mentioned deficiencies of the existing technology, especially for the detection of OH-PAHs, mVOCs and 8-OHdG using the existing detection methods, the sample pretreatment, detection instruments and analysis methods used are all different, and it needs to be divided into three times. To complete the detection problem, provide a new simultaneous detection method of volatile pollutant exposure and effect markers in urine. By improving the sample pretreatment, detectio

Method used

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  • Synchronous detection and application of volatile pollutant exposure and effect markers in urine
  • Synchronous detection and application of volatile pollutant exposure and effect markers in urine
  • Synchronous detection and application of volatile pollutant exposure and effect markers in urine

Examples

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Embodiment 1

[0049] Please see attached Figure 1-4 , the simultaneous detection and application of volatile pollutant exposure and effect markers in urine provided in this example is a detection method and application for group urine samples. Specifically, a petrochemical enterprise in South China is between 20 and 50 years old Taking the urine samples of 38 male professional workers (21 office workers and 17 workshop workers) as an example, the simultaneous detection and application of volatile pollutant exposure and effect markers in urine of the present invention will be described in detail.

[0050] The simultaneous detection method and application of volatile pollutant exposure and effect markers in urine provided in this example, first collect 38 samples, and then perform separate detection in sequence, and select the same (each) urine sample A variety of monohydroxy polycyclic aromatic hydrocarbons OH-PAHs, volatile organic metabolites mVOCs and exposure effect marker 8-hydroxy-2-d...

Embodiment 2

[0125] The synchronous detection and application of volatile pollutant exposure and effect markers in urine provided in this example is basically the same as Example 1, except that it is obtained from the analysis of 38 samples in Example 1 On the basis of the detection method, data and group application of group urine samples, the data and interrelationships are further applied to the analysis or clinical diagnosis of the individual injury impact level of a single individual. The content data and the relationship between the target substances OH-PAHs, mVOCs and 8-OHdG in the urine samples obtained by the detection and analysis of the 38 samples obtained in Example 1 are applied to the individual individuals of individual individuals. Analysis or clinical diagnosis of the level of damage impact, which specifically includes the following steps:

[0126] (1) Data acquisition: Obtain various OH-PAHs, various metabolites of volatile organic compounds mVOCs and exposure effect mark...

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Abstract

The invention discloses a method for synchronously detecting exposure and effect markers of volatile pollutants in urine and application. The method selects OH-PAHs, mVOCs and 8-OHdG which may have correlation in the same urine sample as target detection substances for synchronous extraction, detection and analysis, and the method comprises the following steps: preprocessing the sample; enriching and separating the sample; concentrating and detecting the sample: respectively carrying out on-machine detection on OH-PAHs, mVOCs and 8-OHdG by adopting HPLC-MS/MS, correspondingly analyzing to obtain content data of a plurality of target detection substances in the urine, and analyzing the correlation among the OH-PAHs, mVOCs and 8-OHdG. According to the invention, the analysis of the relationship between the target object content data is applied to the evaluation of the human body exposure characteristics of the two types of pollutants. By optimizing the scheme, multiple target detection objects can be synchronously detected and analyzed, the detection steps are simplified, the detection cost is reduced, and the application range of health exposure risk assessment results is expanded.

Description

technical field [0001] The invention belongs to the fields of pollutant detection, health exposure risk assessment and medical technology, and specifically relates to the simultaneous detection and application of volatile pollutant exposure and effect markers in urine. Background technique [0002] Polycyclic aromatic hydrocarbons (PAHs) are a class of semi-volatile organic pollutants (SVOCs) produced by incomplete combustion of organic matter such as coal, petroleum, and tobacco. Studies have shown that exposure to PAHs may cause irritation to the digestive tract and respiratory tract, and long-term exposure can also cause damage to the human circulatory system and nervous system, resulting in teratogenic, carcinogenic, and mutagenic hazards. Volatile organic compounds (VOCs) are ubiquitous pollutants in the atmosphere, and their sources are very extensive. Industrial production, motor vehicle exhaust, cigarette smoke, and high-temperature cooking foods all produce VOCs. L...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8813
Inventor 郑晶梅航唐斌汤送雄秦瑞欣蔡凤珊于云江
Owner SOUTH CHINA INST OF ENVIRONMENTAL SCI MEP
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