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Drug delivery system for preventing and treating hair loss, preparation method thereof and microneedle patch

A drug delivery system and a hair loss technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Metabolism, reducing oxidative failure, and promoting healing effects

Active Publication Date: 2021-12-14
武汉天时维璟微生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to improve the problem that the current conventional anti-hair loss dosage form has a low transdermal absorption rate, which leads to poor anti-hair loss effect, the application provides a drug delivery system for preventing and treating hair loss and its preparation method and microneedle patch

Method used

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  • Drug delivery system for preventing and treating hair loss, preparation method thereof and microneedle patch
  • Drug delivery system for preventing and treating hair loss, preparation method thereof and microneedle patch
  • Drug delivery system for preventing and treating hair loss, preparation method thereof and microneedle patch

Examples

Experimental program
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Effect test

preparation example 1- preparation example 10

[0090] Since the selection of anti-hair loss small molecule substances is only to adapt to the hair loss symptoms of different causes, and seborrheic alopecia accounts for the largest proportion in the cause of hair loss, minoxidil is selected as the anti-hair loss small molecule substances in the following preparation examples.

[0091] The preparation process of the anti-hair loss component in Preparation Example 1-Preparation Example 10 is the same, and all comprises the following process steps:

[0092] Step 1. Organic phase configuration, put lecithin, anti-hair loss small molecular substances, half of cholesterol and antioxidants into absolute ethanol according to the ratio, heat to 35±1°C, disperse evenly, and maintain a nitrogen atmosphere to remove oxygen throughout the process , to obtain the organic phase.

[0093] Step 2, preparation of coated vesicles, put the remaining half of the cholesterol into the organic phase in step 1, disperse evenly, and obtain coated ve...

preparation example 11

[0098] The difference between Preparation Example 11 and Preparation Example 10 is that Tween-80 of equal mass is used instead of lysine as a dispersant.

preparation example 12

[0100] The difference between Preparation Example 12 and Preparation Example 10 is that the anti-hair loss component is prepared by the following method:

[0101] Step 1, organic phase configuration, put lecithin, anti-hair loss small molecular substances, cholesterol and antioxidants into absolute ethanol according to the ratio, heat to 35±1°C, disperse evenly, keep nitrogen atmosphere to deoxygenate during the whole process, and get The organic phase.

[0102] Step 2, material preparation, dissolve the dispersant in excess deionized water to obtain a dispersant solution, then put the organic phase obtained in step 1 into the dispersant solution, keep stirring during the addition process, continue to stir for 1 hour after the addition is completed, and stir The speed is 350r / min. After the stirring is completed, the material is cooled to room temperature to obtain the anti-hair loss component suspension, the absolute ethanol is evaporated, and the anti-hair loss component is...

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Abstract

The invention relates to a drug delivery system for preventing and treating hair loss, a preparation method thereof and a microneedle patch, and relates to the technical field of hair loss prevention and treatment. The drug delivery system for preventing and treating the hair loss comprises a drug carrying layer and an adhesion layer; the adhesion layer is connected to the drug carrying layer, and the area of the adhesion layer is greater than that of the drug carrying layer; the drug carrying layer is prepared from the following raw materials in percentage by mass: 0.1%-30% of anti-hair loss component; 10%-15% of small molecular sodium hyaluronate; 0.1%-2% of functional additive; and the balance deionized water; the number-average molecular weight of the small molecular sodium hyaluronate is 2 kDa to 10 kDa; and the adhesion layer is prepared from a hydrogel material. The preparation method of the drug delivery system for preventing the hair loss comprises the following steps: preparing materials and integrally forming the prepared materials in a mold, and the drug delivery system for preventing the hair loss can be used for manufacturing the microneedle patch. The microneedle patch prepared by the present application has the advantages of high percutaneous absorption rate and better anti-hair loss effect.

Description

technical field [0001] The present application relates to the field of hair loss prevention technology, in particular to a drug delivery system for hair loss prevention, its preparation method and microneedle patch. Background technique [0002] At present, there are more and more patients with hair loss symptoms. In addition to affecting the patient's image and appearance, hair loss will also have a relatively large negative impact on the patient's psychology and social interaction. At present, the most common type of hair loss is seborrheic alopecia. Seborrheic alopecia is also known as androgenetic alopecia. Due to the increase of androgen in the body, excessive sebum secretion and hyperkeratosis of the hair follicles are caused, forming embolism, affecting the nutrition of the hair follicles, and making the hair follicles Gradually shrinks and destroys, causing hair loss. In addition, excessive sebum can also lead to the growth of scalp fungi, etc. The fungi decompose s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/00A61K45/00A61K47/18A61K47/26A61K47/12A61K47/22A61K47/34A61K47/36A61K47/46A61P17/14A61K31/4166A61K31/56A61K31/7008A61K33/30A61K36/185A61K38/06
CPCA61K9/7084A61K47/183A61K9/0021A61K47/26A61K47/12A61K47/22A61K45/00A61P17/14A61K47/36A61K47/34A61K47/46A61K31/7008A61K31/4166A61K36/185A61K31/56A61K33/30A61K38/06A61K9/127A61K2300/00Y02A50/30
Inventor 叶晓慧
Owner 武汉天时维璟微生物科技有限公司
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