Isoliquiritigenin self-microemulsion, preparation method and application thereof, and application of isoliquiritigenin self-microemulsion to EOE model mice

A technology of isoliquiritigenin and model mice, applied in the field of medicine, can solve the problems of lack of specific drug formulations for controlling esophageal inflammation, and achieve the effects of simple preparation method, easy promotion and improved solubility

Active Publication Date: 2021-12-21
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there is no cure for eosinophilic esophagitis. The goal of its treatment is to relieve symptoms, prevent complications of EOE, and improve the quality of life of patients; At present, the first-line drug for clinical treatment of EOE is topical/swallowing corticosteroids. Although this treatment can effectively control EOE-related inflam

Method used

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  • Isoliquiritigenin self-microemulsion, preparation method and application thereof, and application of isoliquiritigenin self-microemulsion to EOE model mice
  • Isoliquiritigenin self-microemulsion, preparation method and application thereof, and application of isoliquiritigenin self-microemulsion to EOE model mice
  • Isoliquiritigenin self-microemulsion, preparation method and application thereof, and application of isoliquiritigenin self-microemulsion to EOE model mice

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preparation example Construction

[0036] The second aspect of the present invention provides the preparation method of the isoliquiritigenin self-microemulsion comprising at least the following steps:

[0037] S1: Prepare a blank nanoemulsion; specifically, it includes the following steps: (a) add the two co-surfactants into the No. 1 EP tube according to the above mass ratio, and simultaneously add the two surfactants into the No. 2 EP tube according to the above mass ratio put the No. 1 and No. 2 EP tubes in the ultrasonic oscillator for 10-20min; (b) add a certain amount of oil phase to the No. 3 EP tube, according to the above mass ratio, start the Draw a certain amount of surfactant from the No. 1 EP tube and add a certain amount of co-surfactant from the No. 1 EP tube and add them to the No. 3 EP tube; (c) Place the No. 3 EP tube in an ultrasonic oscillator for vibration After 10-20 minutes, a blank nanoemulsion is prepared, and the prepared blank nanoemulsion is stored at 4°C.

[0038] S2: Add isoliqui...

Embodiment 1

[0040] Tween 80 is 4.2g, polyoxyethylene castor oil is 1.8g, PEG400 is 0.5g, 1,2-propanediol is 0.5g, ethyl oleate is 3g, and the amount of isoliquiritigenin is 1.8g. After treatment, there is still a small amount of sediment at the bottom.

[0041] Preparation method: S1: prepare a blank nanoemulsion; specifically include the following steps: (a) add two co-surfactants into No. 1 EP tube according to the above mass ratio, and simultaneously add two kinds of surfactants according to the above mass ratio No. 2 EP tube, and both No. 1 and No. 2 EP tubes were placed in an ultrasonic oscillator for 15 minutes; (b) Add a certain amount of oil phase to No. Draw a certain amount of surfactant in the tube, absorb a certain amount of co-surfactant from the No. 1 EP tube, and add them to the No. 3 EP tube; (c) Place the No. 3 EP tube in the ultrasonic oscillator After shaking for 15 minutes, a blank nanoemulsion was prepared, and the prepared blank nanoemulsion was stored at 4°C.

[0...

Embodiment 2

[0044] Tween 80 is 5.83g, polyoxyethylene castor oil is 1.67g, PEG400 is 1g, 1,2-propanediol is 0.5g, ethyl oleate is 6g, isoliquiritigenin is 2.65g. There is still a small amount of precipitation at the bottom; the preparation method is the same as in Example 1.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an isoliquiritigenin self-microemulsion, a preparation method and application thereof and an application of the isoliquiritigenin self-microemulsion to EOE model mice. The isoliquiritigenin self-microemulsion comprises a surfactant, a cosurfactant, an oil phase and isoliquiritigenin, wherein the surfactant is selected from Tween 80 and polyoxyethylated castor oil, the mass ratio of Tween 80 to polyoxyethylated castor oil is 7: (2-4), the cosurfactant is PEG400 and 1, 2-propylene glycol, the mass ratio of the PEG400 to the 1, 2-propylene glycol is 1: (0.5-1.5), the oil phase is selected from ethyl oleate, the mass ratio of the oil phase to the surfactant to the cosurfactant is (2-4): (5-7): 1, and the isoliquiritigenin reaches a saturated state in the isoliquiritigenin self-microemulsion. The isoliquiritigenin self-microemulsion is used for treating eosinophilic esophagitis, and is applied to EOE model mice. The solubility of the isoliquiritigenin in the isoliquiritigenin self-microemulsion is obviously improved, besides, the preparation method does not change the physical and chemical properties of the isoliquiritigenin, and the preparation method is simple and convenient to popularize.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to isoliquiritigenin self-microemulsion, its preparation method, application and its application in EOE model mice. Background technique [0002] Eosinophilic esophagitis (EOE) is a chronic inflammatory disease related to food allergy. The main pathological manifestation is the infiltration of the esophageal mucosa by a large number of eosinophils (EOS). The clinical manifestations of adult patients are mainly dysphagia, esophageal stricture, food incarceration, and reflux-like symptoms; children mainly present with food refusal and malnutrition. EOE is a global disease, but the geographical distribution is uneven, with a large number of cases seen in North and South America, Eastern and Western Europe, and Australia, and a relatively small number of cases in Asia (including the Middle East). Previous literature reports that the prevalence of EOE is about (5-50) / 100,000, but in th...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/12A61K47/26A61K47/44A61K47/10A61K47/14A61P1/04A61K49/00
CPCA61K9/1075A61K31/12A61K47/26A61K47/44A61K47/10A61K47/14A61P1/04A61K49/0008Y02A50/30
Inventor 曹明卓高勇王泽茜陈晓辉王媛史艳梅
Owner HENAN UNIV OF CHINESE MEDICINE
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