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Assessment of multiple signaling pathway activity score in airway epithelial cells to predict airway epithelial abnormality and airway cancer risk

A cell signaling, epithelial cell technology, applied in the field of genome processing, bioinformatics, can solve problems such as promotion, tumorigenicity, interference, etc.

Pending Publication Date: 2021-12-21
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Smoking interferes with signaling pathways involved in these processes, which may promote tumorigenicity

Method used

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  • Assessment of multiple signaling pathway activity score in airway epithelial cells to predict airway epithelial abnormality and airway cancer risk
  • Assessment of multiple signaling pathway activity score in airway epithelial cells to predict airway epithelial abnormality and airway cancer risk
  • Assessment of multiple signaling pathway activity score in airway epithelial cells to predict airway epithelial abnormality and airway cancer risk

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Embodiment Construction

[0119] The following examples merely illustrate particularly preferred methods and selected aspects connected thereto. The teachings provided therein can be used to construct several tests and / or kits. The following examples are to be construed as limiting the scope of the invention.

[0120] The present invention relates to a method that can identify individuals, especially smokers, who have abnormal / pre-malignant changes in the airway epithelium and / or are at increased risk of developing lung cancer. Measurement of signal transduction pathway activity can identify aberrant signal transduction pathway activity indicative of abnormal airway epithelium, as well as an increased likelihood of pre-malignant changes. According to the present invention, the activity of two or more pathways is determined and converted into an airway abnormality factor, hereinafter also referred to as the (Small / Large) Airway Pathway Abnormality Score, (S / L)APAS, which identifies Individuals with ab...

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Abstract

The present invention relates to means and methods that can identify subjects, who have abnormal changes in airway epithelium and / or are at increased risk for developing an airway cancer, based on a combination of activities of signaling pathways in an epithelial cell sample derived from an airway of the subject. The signaling pathways comprise two or more signaling pathways selected from the group consisting of a TGF-beta pathway, a P13K-FOXO pathway, and a Notch pathway.

Description

technical field [0001] The topics described in this article relate primarily to bioinformatics, the field of genome processing, the field of proteome processing, and related fields. More particularly, the present invention relates to a computer-implemented method for determining whether a subject has abnormal airway epithelium, and to a method for determining a risk score indicative of a risk that a subject with abnormal airway epithelium will develop airway cancer computer-implemented method. The present invention also relates to an apparatus, a non-transitory storage medium, and a computer program for determining an airway abnormality factor indicative of whether a subject has abnormal airway epithelium or indicative of a risk that a subject with abnormal airway epithelium will develop airway cancer risk score. The invention also relates to a kit for determining an airway abnormality factor indicative of whether a subject has abnormal airway epithelium or for determining a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00C12Q1/6886G16H50/20G16H50/50
CPCG16B5/00G16H50/20G16H50/50C12Q1/6886C12Q2600/158G16B20/20C12Q2600/112
Inventor A·范德斯托尔佩I·雅格布斯S·P·L·库伊佩尔斯
Owner KONINKLJIJKE PHILIPS NV