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Composition for removing couperose skin as well as preparation method and application thereof

A composition and capillary technology, applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of red capillary problems, general effects, skin irritation, etc. that cannot be fundamentally resolved, so as to enhance skin barrier and improve microcirculation. , The effect of solving the problem of red blood

Pending Publication Date: 2021-12-24
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the redness-removing products on the market are mainly soothing, and the effect is average. They cannot fundamentally solve the redness problem, and a large number of soothing and repairing ingredients added may not achieve the purpose of synergy, but bring skin irritation. to some excitement

Method used

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  • Composition for removing couperose skin as well as preparation method and application thereof
  • Composition for removing couperose skin as well as preparation method and application thereof
  • Composition for removing couperose skin as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] A composition for removing redness, obtained by uniformly mixing the following components: 1-6 parts of coralline algae extract, 1-5 parts of dogwood fruit extract, 0.1-10 parts of olive leaf extract; preferably, the following components Mix evenly to obtain: 2-5 parts of coralline algae extract, 2-4 parts of dogwood fruit extract, 0.5-5 parts of olive leaf extract; more preferably, the following components are mixed uniformly to obtain: 2.5 parts of coralline algae extract, 4 parts of dogwood fruit extract, 5 parts of olive leaf extract, the above-mentioned parts are by weight.

[0042] In some specific embodiments, the composition of the present invention is prepared by the following steps:

[0043](1) Take coralline algae, dry and pulverize, add 10 times the amount of ethanol to soak for 3 hours, extract by ultrasonic vibration, filter and collect the filtrate; the filtrate is concentrated under reduced pressure at a temperature of 45°C to obtain an extract; add 10 t...

experiment example 1

[0051] Experimental Example 1: Cytotoxicity Test

[0052] MTT is a yellow powder chemical reagent widely used in the detection of cytotoxicity or cell proliferation. The detection principle is that succinate dehydrogenase in the mitochondria of living cells can reduce MTT to water-insoluble blue-purple crystalline formazan and deposit it. In cells, dead cells do not have this function. Dimethyl sulfoxide (DMSO) can dissolve formazan in cells, and the number of living cells can be judged according to the measured absorbance value. The specific experimental method is as follows:

[0053] 1×10 per well in a 96-well plate 4 100 μL of DMEM medium containing 10% bovine serum and 100 μL of human immortalized epidermal cells (HaCaT) were inoculated at the density of each cell, and replaced with serum-free medium after 24 hours of cultivation; , 200 μg / mL (diluted in water) of the redness-removing composition prepared in the above-mentioned Examples 1-12 and Comparative Examples 1-3 ...

experiment example 2

[0059] Experimental example 2: Anti-inflammatory effect test

[0060] Interleukin-6 (IL-6) is a pro-inflammatory cytokine, and enzyme-linked immunosorbent assay (ELISA) can be used to measure the secretion level of IL-6 in human immortalized keratinocytes (HaCaT). The anti-inflammatory effect of the samples was evaluated. The experimental steps are as follows:

[0061] (1) Blank control group: in a 96-well plate according to 1×10 per well 4 Inoculate 100 μL of DMEM medium containing 20% ​​bovine serum and 100 μL of HaCaT cells at a density of 1 cell, replace with serum-free medium after 24 hours of culture, collect the cell culture supernatant, and use human interleukin 6 (IL-6) ELISA detection reagent Box to detect the secretion of IL-6 in HaCat cells;

[0062] (2) Negative control group: HaCat cells were stimulated with 1 μg / ml lipopolysaccharide (LPS) for 6 hours, the cell culture supernatant was collected, and the secretion of IL-6 in HaCat cells induced by LPS was dete...

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Abstract

The invention discloses a composition for removing couperose skin as well as a preparation method and application thereof. The composition comprises the following components in parts by weight: 1-6 parts of a coralline algae extract, 1-5 parts of a dogwood fruit extract, and 0.1-10 parts of an olive leaf extract. The composition for removing the couperose skin, prepared by the invention, not only can be used for improving microcirculation, reducing vasodilation and lowering vascular permeability, but also can be used for resisting inflammation, carrying out relieving and enhancing skin barrier. On the premise of giving full play to respective effects of each component, the components can also achieve a synergistic action, so that the composition has a good couperose skin removing effect, is high in safety and does not irritate the skin.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a composition for removing red blood streaks and its preparation method and application. Background technique [0002] Red blood streak is a kind of chronic skin inflammation, which brings more and more troubles to people's daily life. On the one hand, with age, the circulation speed of the microcirculatory system slows down, the number and quality of blood vessels decrease, and the relaxation of blood vessels accelerates. These series of physiological changes make the skin prone to red bloodshot; on the other hand, due to physical, chemical, After hormones and other factors stimulate the skin barrier to be damaged, the vascular endothelial growth factor (VEGF) secreted by the skin tissue causes blood vessels to dilate and increase the permeability of blood vessels, resulting in facial redness. [0003] Red blood filaments will bring about the production of pro-inflammatory ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9717A61K36/63A61Q19/08A61Q19/00A61P29/00A61P17/00A61P9/14
CPCA61K8/9717A61K8/9789A61Q19/00A61Q19/08A61P29/00A61P9/14A61P17/00A61K36/04A61K36/40A61K36/63A61K2800/82A61K2800/805A61K2800/5922A61K2300/00
Inventor 施丽娟周秋娜金荣熙李境境尹锺赫金延埈
Owner COSMAX CHINA INC
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