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Methods and compositions for treating tumors

An anhydrous and injection technology, which is used in antitumor drugs, drug combinations, pharmaceutical formulations, etc.

Pending Publication Date: 2022-01-07
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Except for our hospital, there are no other reports at home and abroad for the purpose of intratumoral injection to treat tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the preparation of aluminum sulfate for injection

[0040] As prepared by the method of reference CN100425244C. Take by weighing aluminum sulfate 800g (1.20mol) as water purifying agent, dissolve in 1090ml distilled water, filter, add 380ml concentrated sulfuric acid (containing H 2 SO 4 6.62mol), the solution was heated to 72°C, stirred and cooled in a 50°C water bath, and stirred at this temperature for 1 hour. Then the temperature was lowered to room temperature at a rate of 3-5° C. / hour, and stirring was continued for 1 hour. Suction filtration, washing with 95% ethanol three times, and drying at room temperature gave 653 g of flaky crystals with a yield of 81.6%. Weigh 600g (0.90mol) of the above-mentioned crystalline aluminum sulfate, dissolve in 1000ml distilled water, filter, add 367ml concentrated sulfuric acid (containing H 2 SO 4 6.62mol), crystallization by the same method as above. Suction filtration, washing with 95% ethanol, and dryi...

Embodiment 2

[0041] Embodiment 2: Preparation of aluminum sulfate injection

[0042] Prepared by the method of reference CN100425244C. Precisely weigh some aluminum sulfate raw materials that meet the grade for injection, 1.5g of lidocaine hydrochloride, 2mg of methylene blue, and an appropriate amount of water for injection to dissolve, add water for injection to 100ml, filter, fill in 10ml ampoules, seal, heat Autoclaved to obtain aluminum sulfate injection.

[0043] Prepare the aluminum sulfate injection of different concentration specifications according to the above-mentioned method, wherein aluminum sulfate (with anhydrous Al 2 (SO 4 ) 3 Total) contents are: 0.002%, 0.005%, 0.01%, 0.02%, 0.05%, 0.075%, 0.1%, 0.15%, 0.2%, 0.5%, 0.8%, 1%, 1.5%, 2%, 4% , 6%, 8%, and 10%, these injections can be numbered 1-18 in sequence.

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Abstract

The present invention relates to methods and compositions for treating tumors. On one hand, the invention relates to an injection which comprises 0.001%-0.2% of aluminum sulfate in terms of anhydrous substances and water for injection. The injection can also contain a local anesthetic, such as the local anesthetic selected from the group consisting of lidocaine, procaine, chloroprocaine, tetracaine, cocaine, dibucaine, prilocaine, mepivacaine, bupivacaine, etidocaine, mesocainum, ropivacaine, pirocaine or dyclonine, preferably lidocaine such as lidocaine hydrochloride. The injection can also comprise the following coloring agents of methylene blue, indigo blue, brilliant blue, patent blue V, gentian violet, copper sulfate, chlorophyll, sodium iron chlorophyllin, copper chlorophyllin, copper chlorophyllin complex salt, sodium copper chlorophyllin and fast green, preferably methylene blue. The invention also relates to application of the injection in preparation of medicines for treating tumors. The injection provided by the invention shows an excellent effect of inhibiting tumor growth.

Description

technical field [0001] The invention relates to an aluminum sulfate injection for treating tumors, which includes aluminum sulfate and pharmaceutical auxiliary materials, wherein the aluminum sulfate is aluminum sulfate for injection, wherein the content of heavy metals is ≤0.0005%, the content of iron salts is ≤0.004%, and the content of arsenic salts ≤0.0001%. The invention also relates to a preparation method of aluminum sulfate injection. Background technique [0002] According to the inventor's previous application documents, the treatment of bladder tumors is mainly based on local treatment, and the effect of systemic treatment is not good. There are four main types of treatment: surgery, radiation therapy, chemotherapy and immunotherapy. The treatment of superficial bladder transitional cell carcinoma, which accounts for 75-80% of bladder tumors, generally adopts the method of transurethral resection and postoperative intracavity chemotherapy (the most suitable trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K9/08A61K45/06A61P35/00A61P23/02
CPCA61K33/06A61K9/08A61K9/0019A61K45/06A61P35/00A61P23/02
Inventor 徐风华赵冠人史振伟杨飞
Owner GENERAL HOSPITAL OF PLA
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