Fused heterocyclic derivatives
A compound and monocyclic technology, applied in the direction of active ingredients of heterocyclic compounds, organic chemistry, organic active ingredients, etc., can solve difficult problems such as drug resistance
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[0523] By way of a first example about substituent terminology, if the substituent S 1 实例 is S 1 and S 2 One of, and the substituent S 2 实例 is S 3 and S 4 one of, these allocations refer to the embodiments of the present disclosure given according to the following options: S 1 实例 is S 1 and S 2 实例 is S 3 ;S 1 实例 is S 1 and S 2 实例 is S 4 ;S 1 实例 is S 2 and S 2 实例 is S 3 ;S 1 实例 is S 2 and S 2 实例 is S 4 ; and the equivalent for each of these alternatives. For brevity, the shorter term "S 1 实例 is S 1 and S 2 one of, and S 2 实例 is S 3 and S 4 one of", but not in a limiting manner. The above first example of substituent terminology described in general terms is intended to illustrate the various substituent assignments described herein. The terms given herein for The above rules for substituents are extended where applicable to e.g. R 1 , R 2 , R 3 , R 4 , R 5 , G 1 , G 2 , G 3 , G 4 , G 5 , G 6 , G 7 , G 8 , G 9 , G 10 , G 11 ,...
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[0551] Exemplary compounds useful in the methods of the disclosure will now be described with reference to the following illustrative synthetic schemes for their general preparation and the specific examples that follow. The skilled artisan will recognize that to obtain the various compounds herein, the starting materials can be appropriately chosen such that the final desired substituents will be carried through the reaction schemes with or without suitable protection to yield the desired product . Alternatively, it may be necessary or desirable to replace the final desired substituent with a suitable group that can be carried through the reaction scheme and replaced appropriately by the desired substituent. Unless otherwise stated, variables are as defined above with reference to formula (I). The reaction can be carried out between the melting point of the solvent and the reflux temperature, preferably between 0°C and the reflux temperature of the solvent. The reaction can...
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