Copper-induced oxidative polymerization polypyrrole nanoparticles as well as preparation method and application thereof

A technology of polypyrrole nano and oxidative polymerization, which is applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as limited effects, and achieve the effects of simple operation, improvement of tumor microenvironment, and high safety

Pending Publication Date: 2022-01-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the limited effect of the existing polypyrrole for photothermal therapy of cancer, and provide a copper-induced oxidation agent with high safety that improves the tumor microenvironment, combines photothermal therapy with synergistic anti-tumor polymerized polypyrrole nanoparticles

Method used

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  • Copper-induced oxidative polymerization polypyrrole nanoparticles as well as preparation method and application thereof
  • Copper-induced oxidative polymerization polypyrrole nanoparticles as well as preparation method and application thereof
  • Copper-induced oxidative polymerization polypyrrole nanoparticles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Polypyrrole nanoparticles modified by polyethylene glycol to induce oxidative polymerization

[0039] The preparation method of the polyethylene glycol-modified copper-induced oxidatively polymerized polypyrrole nanoparticles comprises the following steps:

[0040] S1. Add 10mL of deionized water to a 50mL single-necked round bottom flask, then add 30mg of polyvinyl alcohol (PVA), gently stir and condense under a heating environment at 90°C for 1 hour, then naturally cool to room temperature; stir at 600-1500rpm Under the condition (magnetic stirring), add 10mL cupric chloride solution (containing 1g cupric chloride) dropwise, continue to stir for 1 hour; Then add 200μL pyrrole monomer (99%, Aladdin) dropwise, 600~1500rpm stirring (magnetic stirring) to react for 24 hours; centrifuge the resulting reaction solution with a low-temperature ultracentrifuge at 5000rpm / min for 10min, remove large particles of nanoparticles, collect the supernatant, centrifuge at 20...

Embodiment 2

[0042] Example 2 A Polyethylene Glycol-modified Copper-Induced Oxidative Polymerized Polypyrrole Nanoparticle

[0043] The preparation method of the polyethylene glycol-modified copper-induced oxidatively polymerized polypyrrole nanoparticles comprises the following steps:

[0044]S1. Add 10mL of deionized water to a 50mL single-necked round bottom flask, then add 50mg of polyvinyl alcohol (PVA), gently stir and condense under a heating environment at 90°C for 1 hour, then naturally cool to room temperature; stir at 600-1500rpm Under the condition (magnetic stirring), add 10mL copper oxide solution (containing 1g copper oxide) dropwise, and continue to stir for 1 hour; then add 200μL pyrrole monomer (99%, Aladdin) dropwise, and stir at 600-1500rpm (magnetic stirring) React for 20 hours; centrifuge the obtained reaction solution with a low-temperature ultracentrifuge at 5000rpm / min for 10min, remove large particles of nanoparticles, collect the supernatant, centrifuge at 20000r...

Embodiment 3

[0046] Example 3 Polypyrrole nanoparticles modified by polyethylene glycol to induce oxidative polymerization

[0047] The preparation method of the polyethylene glycol-modified copper-induced oxidative polymerization polypyrrole nanoparticles refers to Example 1, the difference is that 10 mg, 30 mg, 50 mg, and 100 mg of polyvinyl alcohol are added in step S1, and the remaining parameters and operation Refer to Example 1.

[0048] Scanning electron microscopy and particle size distribution analysis of the obtained polyethylene glycol-modified copper-induced oxidatively polymerized polypyrrole nanoparticles were carried out for their morphology and size, the results can be found in Figure 1~2 . It can be seen from the figure that with the change of the amount of polyvinyl alcohol added from high to low, the electron microscope particle size and hydrodynamic particle size of the obtained polypyrrole nanoparticles modified by polyethylene glycol-modified copper-induced oxidatio...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to copper-induced oxidative polymerization polypyrrole nanoparticles as well as a preparation method and an application thereof. According to the polypyrrole nanoparticles, a copper-containing oxidant is adopted to induce oxidative polymerization of pyrrole monomers, the preparation method is simple to operate, and the particle size of the material can be regulated and controlled through the addition amount of a stabilizer; the prepared polypyrrole nanoparticle material has a good photothermal effect, can significantly improve a tumor microenvironment, and can achieve a synergistic effect after reaching a tumor site to achieve an effect of significantly killing tumor cells; and the polypyrrole nano material has excellent biocompatibility and stability, can be absorbed by an organism, is high in safety, and is very suitable for clinical application as a tumor drug.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to a copper-induced oxidative polymerization polypyrrole nanoparticle and its preparation method and application. Background technique [0002] Photothermal therapy refers to a method of treating diseases by converting light energy into heat energy and using the transformed heat energy. In recent years, due to its strong targeting and wide adaptability, photothermal therapy has attracted extensive attention from researchers. Compared with radiation therapy and surgical therapy in traditional tumor treatment, photothermal therapy significantly reduces the damage to normal tissues in the human body. [0003] Polypyrrole has good biocompatibility, excellent photothermal effect and photostability, and is widely used in the field of photothermal therapy. For example, Chinese patent application CN108815524A discloses a hyaluronic acid-modified polypyrrole-coated dru...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): C08J3/14C08L79/04C08G73/06A61K41/00A61P35/00A61P35/04B82Y5/00B82Y40/00
CPCC08J3/14C08G73/0611A61K41/0052A61P35/00A61P35/04B82Y5/00B82Y40/00C08J2379/04
Inventor梅林吴玫颖曾伟伟刘沅淇陈婷李倩倩
OwnerSUN YAT SEN UNIV