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Silica nanoparticle, preparation method and application thereof, compound and application of compound

A technology of silica and nanoparticles, applied in the field of biomedicine

Inactive Publication Date: 2022-02-01
SHANGHAI WEIKE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the technology currently used to deliver mRNA leaves room for improvement

Method used

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  • Silica nanoparticle, preparation method and application thereof, compound and application of compound
  • Silica nanoparticle, preparation method and application thereof, compound and application of compound
  • Silica nanoparticle, preparation method and application thereof, compound and application of compound

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Embodiment Construction

[0033] One aspect of the embodiments of the present invention relates to a silica nanoparticle in the shape of a dendritic center-radial pore, with a particle diameter in the range of 50-100 nm and a pore diameter in the range of 20-30 nm.

[0034] The technical solutions of the embodiments of the present invention can benefit gene function research, gene therapy research and clinical application based on messenger ribonucleic acid (mRNA).

[0035] Specifically, the silica nanoparticles involved in the embodiments of the present invention have low toxicity to cells, can efficiently load and release mRNA, can effectively introduce mRNA into cells, and have a high transfection rate, which can be beneficial to mRNA-based Gene function research, gene therapy research and clinical application.

[0036] Unless otherwise specified, the numerical ranges in this application may include any numerical values ​​and numerical subranges therein, for example, 50-100nm may include 50nm, 100nm...

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Abstract

The embodiment of the invention relates to a silica nanoparticle, a preparation method and application thereof, a compound and application of the compound. The shape of the silica nanoparticle is a dendritic center-radial pore, the particle size range is 50-100 nm, and the pore size range is 20-30 nm. The silica nanoparticle related to the embodiment of the invention has low toxic influence on cells, can efficiently load and release messenger ribonucleic acid (mRNA), can effectively introduce the mRNA into the cells, have high transfection efficiency, and can be beneficial to gene function research, gene therapy research, clinical application and the like based on the mRNA.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to silicon dioxide nanoparticles, a preparation method, use thereof, a compound and use thereof. Background technique [0002] Messenger ribonucleic acid (mRNA) plays an important role in linking deoxyribonucleic acid (DNA) and proteins during translation in living cells, thus attracting great interest from research and industry, having shown various applications such as vaccines, gene editing and cancer immunotherapy, prevention. [0003] Delivery of mRNA into cells for efficient translation is critical to the development of mRNA technology. However, current techniques for delivering mRNA leave room for improvement. [0004] Accordingly, improved techniques are needed. Contents of the invention [0005] The technical problems solved by the present invention include that there is still room for improvement in the current technology for delivering messenger ribonucleic acid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18B82Y40/00A61P35/00A61K48/00
CPCC01B33/18B82Y40/00A61K48/0033A61K48/005A61P35/00C01P2004/64C01P2006/16
Inventor 杨太华徐天兆
Owner SHANGHAI WEIKE BIOTECHNOLOGY CO LTD