Ovarian regeneration patch and preparation method thereof based on vacuum device

A vacuum device and ovarian technology, applied in the field of cell therapy, can solve the problems of autoimmune response stem cell tumor differentiation, difficult living cells, and curative effect discount, and achieve the effects of avoiding drug loss, promoting follicle development and ovulation, and restoring ovarian function.

Pending Publication Date: 2022-02-08
BEIJING HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, living cells are difficult to preserve and transport, and the loss of living cells is serious when directly injected into the functional layer of the ovarian cortex, which greatly reduces the curative effect, and living cell therapy may cause risks such as autoimmune reactions or stem cell tumor differentiation

Method used

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  • Ovarian regeneration patch and preparation method thereof based on vacuum device
  • Ovarian regeneration patch and preparation method thereof based on vacuum device
  • Ovarian regeneration patch and preparation method thereof based on vacuum device

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Embodiment Construction

[0040] The technical solution in the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0041] In the description of the present invention, it should be noted that unless otherwise specified and limited, the terms "connected" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral Ground connection; it can be mechanical connection or electrical connection; it can be direct connection or indirect connection through an intermediary. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention in specific situations.

[0042] refer to Figure 1-2 As shown, a preferred embodiment of the present invention, a method for preparing an ovarian reg...

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Abstract

The invention relates to the technical field of cell therapy, in particular to an ovarian regeneration patch and a preparation method thereof based on a vacuum device. According to the ovarian regeneration patch preparation method based on the vacuum device, mesenchymal stem cell secreted protein sustained-release particles are subjected to low-temperature centrifugation, then a supernate is removed, and sediment is reserved; the mesenchymal stem cell secretory protein sustained-release particles are suspended again by using a volatile solvent, and a first sealed container with a control valve is filled with the suspended mesenchymal stem cell secretory protein sustained-release particles; and finally, a pelvic cavity material for the obstetrics and gynecology department is flatly laid in a second sealed container, the vacuum device is started, and suspension liquid of the the mesenchymal stem cell-secreted protein particles is evenly laid on the pelvic cavity material for the obstetrics and gynecology department, so the ovary regeneration patch is obtained. The ovary regeneration patch can slowly release active ingredients in mesenchymal stem cells, the problem of early-onset ovarian insufficiency is solved, a better treatment purpose is achieved, the ovarian function is recovered, and follicle development and ovulation are promoted; and moreover, medicine loss and repeated administration can be effectively avoided.

Description

technical field [0001] The invention relates to the technical field of cell therapy, in particular to an ovarian regeneration patch and a preparation method thereof based on a vacuum device. Background technique [0002] Premature Ovarian Insufficiency (POI), also known as Premature Ovarian Failure (POF), refers to the loss of ovarian function in women before the age of 40. Elevated gonadal hormones and decreased estrogen, defined as oligomenorrhea or amenorrhea for at least 4 months, two random (interval > 4 weeks) follicle stimulating hormone (Follicle Stimulating Hormone, FSH) > 25IU / L. [0003] The common symptoms of POI are perimenopausal symptoms, including hot flashes, sweating, sleep disturbance, reproductive tract dryness, decreased libido, irritability and some psychological diseases, which are closely related to the decrease of estrogen, and women with POI often suffer from adverse pregnancy. Clinical management strategies for POI include lifestyle modific...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61K35/28A61K9/70A61K9/52A61K9/00A61P15/08C12N5/0775C12P21/00
CPCA61K38/02A61K35/28A61K9/7023A61K9/5192A61K9/5153A61K9/0034A61P15/08C12N5/0668C12P21/00C12N2509/00C12N2509/10
Inventor 张思辰王少为朱大帅
Owner BEIJING HOSPITAL
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