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Application of anti-NINJ1 antibody in preparation of medicine for treating gout and medicine preparation

A technology of pharmaceutical preparations and antibodies, applied in the direction of antibody medical components, antibodies, drug combinations, etc., can solve the problem of no NINJ1 research, and achieve the effect of relieving gout attacks, improving joint inflammation performance, and improving the incidence of gout.

Pending Publication Date: 2022-02-08
ANHUI PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently no therapeutic targets that directly target this intense inflammatory response, and there are no studies on NINJ1 and gout

Method used

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  • Application of anti-NINJ1 antibody in preparation of medicine for treating gout and medicine preparation
  • Application of anti-NINJ1 antibody in preparation of medicine for treating gout and medicine preparation
  • Application of anti-NINJ1 antibody in preparation of medicine for treating gout and medicine preparation

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Embodiment Construction

[0019] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0020] Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0021] Urate, 10 mg / mL, was purchased from Sigma-Aldrich.

[0022] Purified mouse anti-Ninjurin (anti-NINJ1) neutralizing antibody was purchased from BD Biosciences, cat#610777, 250 μg / mL.

[0023] The experimental methods described in the following examples are conventional methods unless otherwise specified; the reagents and materials can be purchased in the market unless otherwi...

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Abstract

The invention provides an application of an anti-NINJ1 antibody in preparation of a medicine for treating gout and a medicine preparation, belongs to the technical field of biological medicine and molecular targets, and researches that a targeted NINJ1 molecule can inhibit lipid membrane rupture or breakage of a dead fate cell after an inflammasome is activated in a gout process and prevent release of cell contents, therefore, excessive inflammatory response caused by related DAMP can be inhibited, severe inflammation is controlled, and gout attack is relieved. The research finds that gout attack in an animal model can be remarkably relieved by using the NINJ1 specific neutralizing antibody for treatment, so that the targeted NINJ1 can be used for clinical treatment of gout.

Description

technical field [0001] The invention relates to the technical field of biomedicine and molecular targets, in particular to the use and pharmaceutical preparation of an anti-NINJ1 antibody in the preparation of a drug for treating gout. Background technique [0002] Gout is an inflammatory disease caused by the deposition of urate crystals in soft tissues such as joints and non-joints. Its clinical manifestations are extreme pain involving the joints of the lower extremities. Factors such as genetics and metabolism can lead to the accumulation of higher concentrations of uric acid in the blood. Under the stimulation of some physiological changes and external conditions, high concentrations of uric acid precipitate urate crystals and deposit in related tissues. Deposited urate can cooperate with other factors to activate NLRP3 inflammasome, produce active pro-inflammatory cytokine IL-1β, etc. to initiate gout inflammation, and the activation of NLRP3 inflammasome will further ...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P19/06
CPCA61K39/3955A61P19/06
Inventor 陶金辉张宏亮高洁
Owner ANHUI PROVINCIAL HOSPITAL
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