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Preparation method of titanium-based dental implant material loaded with antibacterial polypeptide and antibacterial ions

A technology for antibacterial polypeptides and implant materials, which is applied in the fields of medical science, pharmaceutical formulations, coatings, etc., to achieve the effects of simple and convenient process, favorable growth and low cost

Pending Publication Date: 2022-02-18
广东省华源康泰生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the antibacterial principle of antimicrobial peptides is based on the combination of antimicrobial peptides and bacterial cell membranes and subsequent physical and chemical interactions, orthodontic implant materials loaded with antimicrobial peptides can only kill bacteria that come into contact with them.

Method used

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  • Preparation method of titanium-based dental implant material loaded with antibacterial polypeptide and antibacterial ions
  • Preparation method of titanium-based dental implant material loaded with antibacterial polypeptide and antibacterial ions
  • Preparation method of titanium-based dental implant material loaded with antibacterial polypeptide and antibacterial ions

Examples

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Effect test

Embodiment 1

[0029] Such as figure 1 As shown, this embodiment provides a preparation method of a titanium-based orthodontic implant material loaded with antibacterial polypeptides and antibacterial ions, comprising the following steps:

[0030] S1), the titanium-based implant was ultrasonically cleaned with acetone, ethanol, and pure water in sequence, and each solvent was ultrasonically cleaned for 20 minutes;

[0031] S2), by immersing the ultrasonically cleaned titanium-based implant material in a 5mol / L sodium hydroxide solution for high-temperature hydrothermal reaction for 24 hours, a nanostructured film layer is constructed on the implant surface;

[0032] S3), configure a dopamine solution, adjust the pH to 8.4 with trishydroxymethylaminomethane, immerse the titanium implant on the surface of the above-mentioned nanostructure into the above-mentioned dopamine solution, and react in a shaking table at 37°C to construct a polydopamine self-assembled film, the reaction time For 24h,...

Embodiment 2

[0037] Such as figure 1 As shown, this embodiment provides a preparation method of a titanium-based orthodontic implant material loaded with antibacterial polypeptides and antibacterial ions, comprising the following steps:

[0038] S1), the titanium-based implant was ultrasonically cleaned with acetone, ethanol, and pure water in sequence, and the cleaning time of each solvent was 20 minutes.

[0039] S2), through the steps of immersing the titanium-based implant material treated in S1) in a 5mol / L sodium hydroxide solution for a high-temperature hydrothermal reaction for 24 hours, and constructing a nanostructure film layer on the implant surface;

[0040] S3), configure a dopamine solution, adjust the pH to 8.4 with trishydroxymethylaminomethane, immerse the titanium implant on the surface of the above-mentioned nanostructure into the above-mentioned dopamine solution, and react in a shaking table at 37°C to construct a polydopamine self-assembled film, the reaction time f...

Embodiment 3

[0044] Such as figure 1 As shown, this embodiment provides a preparation method of a titanium-based orthodontic implant material loaded with antibacterial polypeptides and antibacterial ions, comprising the following steps:

[0045] S1), the titanium-based implant was ultrasonically cleaned with acetone, ethanol, and pure water in sequence, and the cleaning time of each solvent was 20 minutes.

[0046] S2), by immersing the titanium-based implant material in a 5mol / L sodium hydroxide solution for high-temperature hydrothermal reaction for 24 hours, a nanostructured film layer is constructed on the implant surface.

[0047] S3), configure a dopamine solution, adjust the pH to 8.4 with trishydroxymethylaminomethane, immerse the titanium implant on the surface of the above-mentioned nanostructure into the above-mentioned dopamine solution, and react in a shaking table at 37°C to construct a polydopamine self-assembled film, the reaction time for 24h. After the reaction, it was ...

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Abstract

The invention provides a preparation method of a titanium-based dental implant material loaded with antibacterial polypeptide and antibacterial ions, a collagen coating loaded with the antibacterial polypeptide and the antibacterial ions is constructed on the surface of the titanium-based dental implant material at the same time, the process is simple and convenient, the cost is low, and the efficiency is high; the dopamine is oxidized to form polydopamine which has good adhesion, and a good intermediate transition layer can be formed on the surface of a matrix. Chemical grafting of the antibacterial polypeptide and chelation of antibacterial ions can be realized by utilizing abundant surface groups of the polydopamine film, so that the synergistic effect of contact antibacterial of the antibacterial polypeptide and antibacterial of the antibacterial ions is realized, the antibacterial efficiency is improved, the antibacterial effect is enhanced, bacterial infection around the implant can be prevented, and the antibacterial effect of the implant is improved. Meanwhile, the antibacterial polypeptide and the antibacterial ions are not prone to causing drug resistance, and the biological activity is guaranteed.

Description

technical field [0001] The invention relates to the technical field of biomedical coatings, in particular to a method for preparing a titanium-based orthodontic implant material loaded with antibacterial polypeptides and antibacterial ions. Background technique [0002] With the acceleration of the aging population in our country and the increase of severe trauma and malignant tumors caused by frequent accidents, there is a huge clinical demand for bone and tooth implant materials. Titanium-based orthodontic implant materials play an important role in relieving pain of patients, restoring basic functions of bones and improving the quality of life of patients. [0003] However, in current clinical application, bacterial infection of titanium-based orthodontic implant materials occurs frequently, and at the same time, there is a problem of slow interface osseointegration, which seriously threatens the life and health of patients. Because the bacteria on the surface of the imp...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/30A61L27/06A61L27/54
CPCA61L27/34A61L27/30A61L27/06A61L27/54A61L2430/12A61L2420/06A61L2420/08A61L2420/02A61L2300/252A61L2300/102A61L2300/404A61L2300/608A61L2400/12C08L79/04
Inventor 张芳郑裕民
Owner 广东省华源康泰生物科技有限责任公司
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