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Systems and methods for evaluating immune response to infection

An inflammatory response, cell technology, applied in instruments, biomaterial analysis, measurement devices, etc., can solve the problems of sepsis specificity or unsatisfactory sensitivity

Pending Publication Date: 2022-02-25
BECKMAN COULTER INC
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  • Claims
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Problems solved by technology

Diagnostic tests—including tests for procalcitonin (PCT) and C-reactive protein (CRP)—are available, but are not as specific or sensitive for sepsis

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  • Systems and methods for evaluating immune response to infection
  • Systems and methods for evaluating immune response to infection
  • Systems and methods for evaluating immune response to infection

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Embodiment Construction

[0031] Previous efforts to provide an objective diagnostic test for sepsis have included hematological cell analysis. Abnormal white blood cell counts (WBC) are often associated with infection, but they are not unique to sepsis. More recently, assessment of other cell populations, such as immature granulocytes, has been considered as a factor in assessing the likelihood that a patient has or is developing sepsis. Other suggestions include considering cell population parameters such as monocyte volume distribution width or neutrophil volume distribution width as potential indicators of sepsis. These hematological approaches tend to focus on white blood cells, including monocytes, lymphocytes, and neutrophils known to be involved in the immune response to infection.

[0032]Surprisingly, UMALS light-scattering measurements of non-nucleated red blood cells (NNRBCs) -- either alone or in combination with other blood cell population parameters -- have been found to be good predict...

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Abstract

The present invention relates to systems and methods for characterizing immune response to infection by using cellular analysis, such as a hematological cellular analyzer. In some instances, the immune response may be characterized as normal or abnormal based on one or more blood cell population parameters. In some instances, abnormal characterization may be used to identify patients with sepsis or at elevated risk of developing sepsis.

Description

[0001] Cross References to Related Applications [0002] This application is related to and claims the benefit of Provisional Patent Application 62 / 873,575, entitled "Systems and Methods for Assessing Immune Response to Infection," filed in the U.S. Patent Office on July 12, 2019. Background technique [0003] Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a global healthcare crisis that affects more than 30 million people worldwide each year. The incidence of sepsis is increasing by 1.5% per year, making it a major global medical problem. Sepsis has a high mortality rate, killing more people than prostate cancer, breast cancer, and HIV / AIDS combined. [0004] In addition to the death toll, sepsis is also costly to healthcare facilities. Costs associated with sepsis exceed $24 billion and can include longer hospital stays, ICU admissions, readmissions, and extensive testing and patient monitoring. [0005] Seps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N35/00
CPCG01N33/48G01N35/00584G01N33/56966G01N33/56972G01N33/80G01N2800/7095G01N2015/1006G01N15/1459G01N2015/012G01N2800/26G01N2800/52
Inventor 利利阿纳·特吉多罗伯特·T·马加里戴安娜·卡雷亚加申晌奕
Owner BECKMAN COULTER INC
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