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Compositions and methods related to cleaning particles

A technology of particles and medicaments, applied in the field of compositions and methods related to removing particles

Pending Publication Date: 2022-03-04
NANOTICS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these and other pathways involve a net upregulation of the subject's immune system, inducing potentially severe symptoms and / or other significant side effects resembling autoimmune disorders

Method used

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  • Compositions and methods related to cleaning particles
  • Compositions and methods related to cleaning particles
  • Compositions and methods related to cleaning particles

Examples

Experimental program
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Effect test

Embodiment 1

[0421] Example 1 - Method for treating cancer

[0422] A human patient is identified by a medical practitioner as having a cancer (eg, lung, colon, breast, brain, liver, pancreatic, skin, or blood cancer) that excretes soluble TNFR or soluble IL-2R. The patient is administered a composition comprising particles (described herein) that bind to and sequester soluble TNFR or IL-2R in an amount effective to treat cancer. Optionally, the patient is administered a "maintenance dose" of the composition to maintain inhibition of the action of soluble TNFR or IL-2R, thereby continuing to enhance immune surveillance of cancer in the patient.

Embodiment 2

[0423] Example 2 - Method of detoxifying a person

[0424] There are human patients with symptoms of toxicity associated with botulinum toxin. The patient is administered a composition comprising particles (described herein) that bind to and sequester soluble botulinum toxin in an amount effective to ameliorate one or more symptoms associated with toxicity.

Embodiment 3

[0425] Example 3 - Method for treating viral infections

[0426] Human patients are identified as having HIV-1 infection by a medical practitioner. The patient is administered a composition comprising particles (described herein) that bind to and sequester soluble HIV-1 virions in an amount effective to reduce viral titers in the patient's circulation. The patient is given a "maintenance dose" of the composition to maintain the reduction in HIV-1 virion titer, thereby suppressing infection in the patient, and reducing the likelihood of viral transmission to one another.

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Abstract

The present invention relates to compositions and methods related to scavenging particulates. The present invention provides scavenging particles, methods for treating a subject suffering from cancer, an autoimmune disease, a neurodegenerative disease, methods for promoting healthy aging in a subject, methods for treating a metabolic disorder in a subject, and methods for increasing muscle mass in a subject. The present disclosure provides, among other things, compositions that bind to and inhibit the biological activity of soluble biomolecules and pharmaceutical compositions thereof. Compositions may include a plurality of particles that specifically bind to a target, such as a soluble biomolecule or biomolecule on the surface of a pathogen, to inhibit the target (or pathogen) from interacting with other molecules or cells. The disclosure also provides certain applications (e.g., therapeutic applications) where the compositions are useful.

Description

[0001] This application is the PCT international application PCT / US2016 / 040022 submitted on June 29, 2016, which entered the Chinese national phase on February 27, 2018. Method" is a divisional application of the invention patent application. [0002] priority [0003] This application claims U.S. Provisional Patent Application No. 62 / 186,838, filed June 30, 2015, U.S. Provisional Patent Application No. 62 / 198,519, filed July 29, 2015, U.S. Provisional Patent Application No. 62 / 198,519, filed July 29, 2015 Priority of Patent Application No. 62 / 198,541, U.S. Provisional Patent Application No. 62 / 236,507, filed October 2, 2015, and U.S. Provisional Patent Application No. 62 / 319,092, filed April 6, 2016, the aforementioned U.S. Provisional Patent Each of the applications is hereby incorporated by reference in its entirety. technical field [0004] The present invention relates to compositions and methods related to the removal of particles. Background technique [0005] Man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K39/395A61K38/16A61K9/16A61K47/02A61K47/04A61K47/36A61K47/32A61K47/26A61P37/02A61P25/28A61P39/06A61P3/00A61P21/00
CPCA61K47/6923A61K47/6937A61K47/6927A61P37/02A61P25/28A61P39/06A61P3/00A61P21/00A61K47/6949A61K45/00A61P31/18A61P35/00A61P39/00A61K38/17A61K38/19A61K39/395A61K9/0019A61K47/02A61K9/5078A61K9/5115Y02A50/30A61K9/143A61K9/146
Inventor L·霍索恩J·道奇森
Owner NANOTICS LLC
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