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System and method for generating biological assembly

A generation system and assembly technology, applied in the field of biological assembly generation system, can solve the problems of inability to realize fine manipulation of samples such as organoids, and limit the construction of biological assemblies

Active Publication Date: 2022-03-15
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the existing methods for arranging and assembling organoids and other samples usually lack the ability to precisely select, orientate and adjust the orientation and angle of organoids and other samples in space, and cannot achieve fine manipulation of samples such as organoids , which limits the construction of biological assemblies with complex arrangements

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  • System and method for generating biological assembly
  • System and method for generating biological assembly
  • System and method for generating biological assembly

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Embodiment Construction

[0049] The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are only some of the embodiments of the application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

[0050] In the following description, a lot of specific details are set forth in order to fully understand the application, but the application can also be implemented in other ways different from those described here, and those skilled in the art can do without violating the connotation of the application. By analogy, the present application is therefore not limited by the specific embodiments disclosed below.

[0051] Secondly, the present application is described in detail in comb...

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Abstract

The invention discloses a system and method for generating a biological assembly, and the method comprises the steps: employing an ultrasonic transducer array comprising a plurality of array elements which are arranged in an array, generating a plurality of focus point sound fields in a culture medium, forming different sound trap patterns, and combining with different sound traps according to a time proportion to form different composite sound trap patterns. The biological units such as organoids are subjected to the action of acoustic radiation force in the sound trap or the composite sound trap, so that fine control such as accurate selection, position movement, angle adjustment, directional arrangement and clamping assembly is carried out on the biological units, and a biological assembly with a complex arrangement structure can be constructed; the method is beneficial to exploring the action evolution mechanism between different types of biological units, and provides a nearly real model for studying the tissues or organs and case processes of human beings or other organisms.

Description

technical field [0001] The present application relates to the technical fields of tissue engineering and biomanufacturing under biomedical engineering, and in particular to a system and method for generating biological assemblies. Background technique [0002] In the field of biological tissue engineering and manufacturing technology, various types of cells are arranged and assembled in an orderly manner to form a biological assembly, which is conducive to exploring the mechanism of evolution between different types of cells, and can be used for the study of human or other biological tissues. Or organs and case processes provide a model close to reality, which is of great significance. For example, organoids are three-dimensional (3D) cell cultures that reproduce key physiological characteristics and specific structures of tissues by inducing differentiation of pluripotent stem cells from humans or other organisms. After different kinds of organoids are assembled and co-cul...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/42
CPCC12M21/08C12M35/04
Inventor 马腾高泽平张琪郑海荣
Owner SHENZHEN INST OF ADVANCED TECH
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