102 results about "Radiation force" patented technology

The invention provides a cell acoustic characteristic parameter estimation method and system based on a full-connection neural network and a computer medium, and relates to the technical field of biomedical engineering and micro-nano operation, and the method comprises the steps: constructing a three-layer spherical shell model of a target cell, defining the radius, density and sound velocity of each layer and a surrounding medium, and constructing a three-layer spherical shell model of the target cell; the acoustic impedance and the wave number of each layer are calculated; obtaining a transducer driving parameter, a displacement speed of the cell or equivalent particle solid sphere particle, and physical parameters of the cell and a medium; inputting the input feature data into a pre-trained full-connection neural network model to output acoustic characteristic parameters such as a scattering coefficient and an internal refraction coefficient; and calculating acoustic radiation force based on the acoustic characteristic parameters to realize dynamic control. Based on the full-connection neural network and the three-layer spherical shell model, the cell acoustic parameters are efficiently and accurately estimated, the problems that a traditional method is complex in calculation and insufficient in precision are solved, and accurate operation of the acoustic tweezers on the cells is achieved.

A device and method for assembling objects by generating an axial acoustic radiation force in order to position the objects on pressure nodes and / or antinodes and generating a transverse acoustic radiation force in order to move the thus positioned objects on a porous membrane contact structure.

The invention relates to the technical field of soil physical parameter in-situ measurement, and discloses a soil layer natural water content portable intelligent measuring instrument based on multi-source sensing fusion, which comprises a composite probe assembly and an intelligent measurement and control host which are physically connected, the composite probe assembly is configured to be inserted into a soil layer to be tested to construct a multi-physical field test environment, and an electrical transceiving unit and an acoustic transceiving unit are integrated in the composite probe assembly. By constructing a cross physical field excitation and multiphase parameter collaborative decoupling mechanism, a multidimensional dynamic correlation model is established by using the thermosensitive drift characteristic of the sound velocity of a mixed medium during thermal disturbance and the transient step response of a dielectric constant under an acoustic radiation force field; the problems that the coupling influence of the water content and the volume weight cannot be distinguished and the conductivity of bound water and the conductivity of free water are difficult to separate in a traditional means are effectively solved, and four independent physical quantities including the volumetric water content, the in-situ dry volume weight, the bound water content and the actual conductivity of pore water are synchronously inverted through a single probe. And the decoupling precision of the equipment on complex multi-phase soil medium parameters is improved.

The present invention discloses a wireless cross-domain acoustic communication system and method based on acoustic holography. The acoustic holographic device used for cross-domain acoustic communication consists of a single-layer acoustic holographic phase plate, an array transducer, and a camera vision module, wherein each array element of the array transducer has two states: on / off. After receiving the communication coding signal transmitted in the water, the transducer array elements at the corresponding positions can be sequentially selected and the dynamic regulation of the incident sound field can be realized. Then, the sound is transmitted to the water-air interface through the single-layer holographic phase plate and phase-modulated. Under the action of the acoustic radiation force, the interface will deform. The camera vision module is used to capture and parse and decode the deformation of the water surface, completing the wireless reception of information across the water-air interface. The present invention can directly transmit underwater information to the air. The equipment is simple and the relative position requirements of the transmitting and receiving devices are not strict. It is applicable to liquid environments of any temperature, salinity, and density.

The invention provides a real-time analysis method for energy distribution of an ultrasonic hemorrhoid therapeutic apparatus, which comprises the following steps of: defining a boundary region of an initial displacement distribution map by using a boundary region of recurrent internal hemorrhoid and scar tissue, and extracting differential mechanical response characteristics of the boundary region, identifying the position of a high strain set area of the differential mechanical response characteristics as a shear strain concentration area; analyzing a strain value of the position of the shear strain concentration area, and if the strain value exceeds a preset strain threshold value, analyzing sound beam path deviation caused by sound radiation force pulse refraction in the scar tissue through two-dimensional correlation to obtain focus offset; adjusting the displacement distribution diagram through the boundary of the energy deposition region, and extracting the mechanical property distribution of the boundary region to obtain the energy deposition distribution of the target hemorrhoid tissue; and through the energy deposition distribution of the target hemorrhoid tissue, optimizing sound beam deflection parameters, obtaining target sound beam control parameters, and determining an energy deposition area.

Various examples are provided related to estimation of viscoelasticity of an arterial or venous wall. In one example, a method includes obtaining ultrasound data of an arterial or venous wall for a defined acoustic radiation force; and determining viscoelasticity of the arterial or venous wall. The viscoelasticity can be determined based upon correlation between measured and simulated wall velocity of the ultrasound data in a space-time, a wavenumber-frequency, wavenumber-time, or space-frequency domain; or in a sequential manner by determining the elastic part of the modulus by matching measured and simulated phase velocities and determining the viscoelasticity part by matching measured and simulated wall velocities; or a combination of both. The simulated velocity can be determined for a wall thickness and viscoelastic modulus of the arterial or venous wall through full wave analysis. In another example, a system includes an ultrasound scanner and a computing device that can implement the method.

Various examples are provided related to methods and systems to reconstruct 3D image / map for the stiffness of soft tissues. In one example, a method includes obtaining particle velocities from generated mechanical waves in tissue of a subject; reconstructing a stiffness map of soft tissue in a region of interest (ROI) from the particle velocities; and generating an image of the stiffness map for rendering on a user device. In another example, a system includes an ultrasound scanner for shear wave elastography (SWE) and a computing or processing device that can obtain particle velocities; reconstruct a stiffness map of soft tissue in a ROI from the particle velocities; and generate an image of the stiffness map for rendering. The particle velocities can be generated from acoustic radiation forces produced by the ultrasound scanner.

The invention discloses a biological tissue viscoelasticity optical coherence elastography method, system and equipment, and relates to the technical field of biological tissue viscoelasticity measurement. Non-contact biological tissue viscoelastic mechanical property detection is achieved through acoustic radiation force optical coherence elastography, the device can be applied to application scenes with biopsy requirements, distortion of a sound pressure field is reduced by applying the focal length-diameter ratio of the ultrasonic transducer and the frequency of an excitation signal, and the detection accuracy of the viscoelastic mechanical property of the biological tissue is improved. The capturing capability of tiny deformation of the biological tissue is improved, and the imaging quality and accuracy of the obtained displacement data of the biological tissue are improved, so that the accuracy of viscoelasticity calculation of the biological tissue is improved; meanwhile, viscoelasticity calculation is carried out on the phase velocity frequency dispersion curve of the biological tissue based on the surface acoustic wave frequency dispersion model, main energy distribution corresponding to elastic waves can be calculated, the detection and recognition effect is improved, and the accuracy of viscoelasticity calculation of the biological tissue is improved.

The invention relates to the technical field of acoustic driving, in particular to a passive ultrasonic resonance driving device. The device comprises a resonant cavity body, a standing wave focusing assembly, a spiral torque assembly and a friction gradient assembly are sequentially arranged in an inner cavity of the resonant cavity body, and the standing wave focusing assembly is used for focusing external incident ultrasonic waves to form standing wave nodes, generating vertical acoustic radiation force and driving a floating ball in the inner cavity of the standing wave focusing assembly to move in the axial direction. The spiral torque assembly is located below the standing wave focusing assembly, and a spiral groove of the spiral torque assembly converts longitudinal vibration into rotating torque. Through 20-100kHz broadband ultrasonic adjustment, the functions of lifting of the standing wave focusing assembly, rotation of the spiral torque assembly and sliding of the friction gradient assembly are activated in sequence, the function singleness of a traditional passive acoustic device (such as acoustic tweezers capable of only suspending) is broken through, a floating ball is driven to ascend and descend at 20kHz, cell interlayer positioning is completed, and the operation is simple and convenient. The 60 kHz trigger push teeth and the straight tooth grooves are in contact meshing through acoustic radiation force, so that the rotating shaft rotates, and the micro cutting tool bit is controlled.

The present application relates to the technical field of nanomanipulation, and more particularly to a method and device for manipulating nanoparticles based on the principle of acoustic streaming suppression, the method comprising the following steps: S1. setting a microfluidic chip with a cavity; S2. establishing a target standing wave acoustic field in the cross section of the cavity, wherein the sound pressure node plane of the target standing wave acoustic field is parallel to the adjacent side wall of the cavity; S3. introducing a fluid containing nanoparticles into the cavity, and the nanoparticles can be driven to the sound pressure node region under the action of acoustic radiation force and form a stable aggregation cluster; the device comprises a microfluidic chip, the microfluidic chip is provided with a cavity, and the surface of the microfluidic chip is provided with an acoustic wave driving structure, and the sound pressure node plane of the standing wave acoustic field generated by the acoustic wave driving structure is parallel to the adjacent side wall of the cavity. The present application can realize the directional or point manipulation of nanoparticles under the action of actively suppressing acoustic streaming interference.

The application belongs to the technical field of medical magnetic resonance image reconstruction, and discloses a magnetic resonance acoustic radiation force imaging reconstruction method and a system thereof. The method comprises the following steps: acquiring two groups of undersampling data; constructing a model based on the undersampling data and to-be-decided variables, wherein the model is a weighted sum of minimization functions, a data consistency function is used to measure the deviation between each group of undersampling data and k-space data under the same undersampling template calculated based on a corresponding to-be-solved complex number graph, a fitting consistency function is used to measure the deviation between any one complex number graph and a fitting graph thereof, the fitting graph is obtained by fitting based on another complex number graph and a phase difference, and a phase difference sparsity function is used to measure the sparsity of the phase difference; solving the model, and reconstructing the acoustic radiation force image of the sample based on the solving result. According to the method, the positioning accuracy can be ensured, and the imaging speed is accelerated.

The invention relates to a multi-part moxibustion auxiliary nursing device and a method thereof, and belongs to the technical field of modern rehabilitation and daily health care, and the method comprises the following steps: S1, arranging a sound wave agglomeration flow channel and a downstream variable cross-section cyclone separation guide pipe; s2, the driving frequency is corrected along with temperature adjustment, the pipe diameter is made to be integral multiples of the half-wavelength, and it is ensured that standing wave nodes are located in the center of the section; s3, moxa-moxibustion smoke is introduced, and the flow speed is controlled to be 2-4 m / s so that the laminar flow state can be kept; s4, starting 27 to 29 kHz, gt; 140dB ultrasonic standing waves are adopted, and tar is driven by acoustic radiation force until wave nodes are gathered into gt; 10 [mu] m large particles; s5, the airflow tangentially enters an inverted-cone-shaped pipe, large particles are captured through centrifugal force, and medicine volatile oil gas is discharged from the center. According to the method, harmful substances such as polycyclic aromatic hydrocarbon and the like are efficiently removed, meanwhile, monoterpenoids and sesquiterpenoids volatile oil components in the moxa smoke are reserved to the maximum extent, and the medicinal value of moxibustion nursing is ensured.

The invention relates to the technical field of acoustic wave device application and biological tissue engineering, in particular to a method for constructing a multi-component heterogeneous fiber structure under the assistance of acoustic tweezers. According to the method, an acoustic tweezers technology and a microfluidic spinning technology are combined, an electric signal is converted into an acoustic surface wave through the piezoelectric effect of a piezoelectric material, and a beam-shaped acoustic standing wave field is formed in a microchannel of a specific structure; different target cells form a stable fiber configuration under the interaction of microchannel limitation and acoustic radiation force, and spatial precise classification and arrangement of multiple types of cells are realized. The low-temperature-sensitive hydrogel is introduced in the cell injection process, and the fiber scaffold is formed after ultraviolet curing, so that the fiber structure of the cells is still maintained after the sound field is removed. The cells treated by the surface acoustic wave can form a complex three-dimensional bionic tissue structure more easily, and the cell viability is remarkably improved. Various fiber structures can be formed by regulating and controlling sound field parameters, and great potential is shown in the field of in-vitro barrier model construction.

The invention relates to the technical field of micropore machining, in particular to an ultrasonic micropore machining method and device, and the ultrasonic micropore machining method comprises the steps that a first ultrasonic vibration table is arranged between a workbench and a workpiece; the ultrasonic cutter punches the workpiece; the ultrasonic vibration table generates vibration and transmits the vibration to the grinding material flowing above the workpiece; determining the sound stream drag force Fdrag of the first ultrasonic vibration table on the abrasive particles in the abrasive material; determining the acoustic radiation force Frad of the first ultrasonic vibration table on the abrasive particles in the abrasive material; and the impulse I of the abrasive particles in the horizontal direction is determined based on the acoustic streaming drag force Fdrag and the acoustic radiation force Frad, and the impulse I is made to be larger than 0. And abrasive particles are driven to move through ultrasonic waves, so that the technical effect of improving the machining quality is achieved.

The application provides a solder ball coating method and device and a semiconductor packaging production line, relates to the field of solder ball surface coating, and is used for solving the problems of mechanical contact, surface damage, pollution introduction, incomplete coating and uneven thickness during solder ball surface coating. The solder ball coating method comprises the following steps: generating an ultrasonic standing wave field; placing a solder ball to be processed at a standing wave node position of the ultrasonic standing wave field, so that the acoustic radiation force generated by the standing wave node position can make the solder ball to be processed suspended in a non-contact state; feeding an organic coating material into the standing wave node position; and making the organic coating material deposited on the surface of the solder ball to be processed to form an organic coating. By constructing the ultrasonic standing wave field, the solder ball to be processed is suspended at the standing wave node by the acoustic radiation force, the organic coating material is coated in the suspended state, the collision friction and impurity pollution are reduced, the coating completeness and uniformity of the solder ball surface are improved, and the subsequent welding reliability and packaging yield are improved.

A liquid ejection device including an ejection head that ejects a liquid, a liquid supply flow path that supplies the liquid to the ejection head, an ultrasonic generator provided with an ultrasonic element that transmits ultrasonic waves in a first direction that intersects with a flow direction of the liquid in the liquid supply flow path, and a branch flow path that branches in a second direction that intersects the flow direction and the first direction from a position of the liquid supply flow path where the ultrasonic waves are transmitted, wherein the ultrasonic generator that generates a gradient of acoustic radiation force in which the acoustic radiation force increases from the liquid supply flow path toward the branch flow path.

The application belongs to the field of physical property measurement, and discloses a kind of electroplating additive concentration online detection method and system based on multispectral fusion, comprising: guiding flow electroplating liquid through detection cell, control transducer array generates sub-cavitation megahertz standing wave field, utilize acoustic radiation force to drive free gas bubble to gather to wave crest area, make node area form the light path of no scattering interference;Real-time monitoring impedance phase, when reaching resonance extreme point, produce synchronous trigger signal, drive light source to emit ultraviolet wave band light beam, visible wave band light beam and near infrared wave band light beam to light path;Extract the intensity correction absorption brightness parameter of main salt reference wavelength, obtain response sequence and output additive concentration, the application reconstructs the phase distribution of measurement environment, blocks random scattering to the erosion of spectral information, ensures the fidelity of measurement data corresponding to physical fact, solves the problem that trace component signal is hidden in complex matrix.

This invention discloses a method for the synergistic metabolic analysis of multiple components of traditional Chinese medicine (TCM) integrated with the gut microbiota. After initializing the microbiota ecosystem, a solution of multi-component TCM extracts is continuously injected into a microfluidic chip. Stable isotope-labeled precursors are pulsed into a specific simulation region to perform spatial isotope encoding. A standing wave acoustic field is applied at the sampling node of the microfluidic chip, and multiphase fluid spatial splitting is performed using the difference in the primary acoustic radiation force experienced by the particles to derive cell-free TCM metabolites. The cell-free TCM metabolites are separated by chromatography and gas phase drift separation. A four-dimensional metabolic feature array is constructed, and the absolute value of the mass shift is calculated for spatial inverse decoding. Closed-loop feedback is triggered based on the rate of change of target metabolite ion abundance, increasing the amplitude of the standing wave acoustic field pressure to confine intestinal bacteria and performing in-situ enrichment of synergistic metabolic intermediates. This invention realizes the spatial metabolic trajectory tracing and network reconstruction of multiple components of TCM in a complex gut microbiota ecosystem.

The present description relates to a printing nozzle (20) for a 3D printer comprising a duct (21) that has an opening (23), wherein the duct (21) contains a fluid material to be printed (30) which forms an interface (31) with the air at the opening (23), wherein the printing nozzle further comprises an electro-acoustic transducer (40) configured to generate and send first ultrasonic waves (50) through the fluid material to be printed (30) to the interface (31), resulting in the formation of a droplet (32) of the fluid material to be printed at the interface (31) as a result of acoustic radiation forces.

The invention relates to the technical field of micron-sized droplet jet flow and ink jetting, in particular to an acoustically-driven micro-droplet jetting method and device, and the method comprises the steps that to-be-jetted liquid is stably conveyed to a nozzle micropore assembly; generating an ultrasonic signal, and driving an ultrasonic transducer after power amplification; the resonant vocal cavity nozzle is driven by the ultrasonic transducer, and a stable standing wave sound field with a sub-wavelength scale is formed in the cavity; acoustic radiation force is used for acting on a liquid column at the end of the spray head, and non-contact separation and directional spraying of liquid drops are achieved. The nozzle is controlled by the multi-axis motion platform to move on the substrate, so that liquid drops are deposited according to a preset track. According to the method and the device, the problems of nozzle blockage and the like caused by high viscosity or high solid content of liquid in a traditional piezoelectric or electrofluid driving mode are solved; the control precision of the liquid drop size and the spraying speed can be remarkably improved, and the device has excellent fluid adaptability and spraying stability and is particularly suitable for precise deposition and graphical jet printing of complex fluid such as photoresist, metal slurry and functional nano materials.

A cellular mechanical property measurement and sorting method comprises: cells to be sorted being arranged in a straight line after passing through a standing wave acoustic field generated by a first interdigital transducer; the cells flowing through a focused acoustic field generated by a second interdigital transducer, and the focused acoustic field generating a radiation force on the cells, such that the cells are deformed; performing calculation according to information of the radiation force and deformation, so as to obtain elastic moduli of the cells; determining the positions of the cells, and selectively driving, with designed delay time, interdigital transducers in a cell sorting unit according to the moving speeds of the cells and the distances between the cells and the sorting unit, and triggering, according to the elastic moduli, a corresponding interdigital transducer to generate a planar acoustic field, so as to sort the cells.

The application belongs to the field of physical property measurement, and discloses a kind of electroplating additive concentration on-line detection method and system based on multispectral fusion, comprising: guiding flow electroplating liquid through detection cell, control transducer array to generate sub-cavitation megahertz standing wave field, utilize acoustic radiation force to drive free gas bubble to gather to wave crest area, make nodal area form the light path of no scattering interference;Real-time monitoring impedance phase, when reaching resonance extreme point, produce synchronous trigger signal, drive light source to emit ultraviolet wave band light beam, visible wave band light beam and near infrared wave band light beam to light path;Extract the intensity correction absorption brightness parameter of main salt reference wavelength, obtain response sequence and output additive concentration, the application reconstructs the phase distribution of measurement environment, blocks random scattering to the erosion of spectral information, ensures the fidelity of measurement data corresponding to physical fact, solves the problem that trace component signal is hidden in complex matrix.

The invention relates to an automatic assisted reproduction system based on sound-driven bubble microfluid, and belongs to the field of micro-nano operation robots. Comprising the key steps of focusing, capturing, rotating, three-dimensional reconstruction and evaluation and the like, and the problems of high cost and long period in traditional manual operation are solved. The system utilizes secondary radiation force generated by sound wave driving bubble vibration to perform non-contact accurate control on oocytes or embryos. Meanwhile, multi-angle image capture is realized in combination with a three-degree-of-freedom operation platform, and continuous and stable three-dimensional reconstruction and morphological evaluation of the embryo in a long-period culture process are supported. Wherein the deep learning neural network is responsible for analyzing an embryonic development image in real time, and the intelligent algorithm is used for dynamically optimizing an operation path and parameters, so that the system is ensured to efficiently and accurately complete tasks without manual intervention, and the stability and success rate of operation are remarkably improved.

The present application relates to the field of micro-droplet jet and inkjet technology, and particularly relates to an acoustic driving micro-droplet jetting method and device, which comprises: stably delivering a liquid to be jetted to a nozzle micro-hole assembly; generating an ultrasonic signal, which drives an ultrasonic transducer after power amplification; driving the resonant acoustic cavity nozzle through the ultrasonic transducer to form a stable sub-wavelength scale standing wave acoustic field in the cavity; using the acoustic radiation force to act on the liquid column at the end of the nozzle to realize the non-contact separation and directional jetting of the droplet; and moving the nozzle on the substrate through a multi-axis motion platform to realize the deposition of the droplet according to a predetermined track. The method and device avoid the nozzle blockage and other problems caused by the high viscosity or high solid content of the liquid in the traditional piezoelectric or electrohydrodynamic driving mode; can significantly improve the control accuracy of the droplet size and jetting speed, have excellent fluid adaptability and jetting stability, and are particularly suitable for the precise deposition and patterning jetting of complex fluids such as photoresist, metal paste and functional nanomaterials.

Method for estimating fat content based on shear wave propagation, wherein the method comprises the following: the transmission (30) of an acoustic radiation force excitation to a patient; the measurement (32), using ultrasound, of tissue displacements at tissue locations within a patient in response to a shear wave resulting from acoustic radiation force excitation; the calculation (36), by a processor (18), of the damping of the shear wave from the displacements; calculating (37) a center frequency, a bandwidth or a center frequency and a bandwidth of the displacements as a function of time; the estimation (40) by the processor (18) of the fat content of the tissue as a function of the shear wave damping, wherein the estimation (40) of the fat content comprises the estimation (40) of the fat content as a function of the center frequency, the bandwidth or the center frequency and the bandwidth; and the display (42) of an indication of the fat content.

The invention relates to an ultrasonic blood pressure measuring method and system based on acoustic radiation force. The method comprises the following steps: for any blood vessel ROI region, constructing a pressure measurement equation of the blood vessel ROI region; when the pressure measurement sensitivity A and the pressure measurement intercept B are calculated, at least transmitting acoustic radiation force signals to the blood vessel ROI, acquiring an acoustic radiation force subharmonic amplitude under each acoustic radiation force signal, and calculating the pressure measurement sensitivity A and the pressure measurement intercept B in the pressure measurement equation based on each acoustic radiation force signal and the corresponding acoustic radiation force subharmonic amplitude; when ultrasonic blood pressure measurement is conducted on the blood vessel ROI, the pressure measurement subharmonic amplitude of the blood vessel ROI under the optimal incident sound pressure is obtained, and the obtained pressure measurement subharmonic amplitude is substituted into the pressure measurement equation to generate the blood pressure value of the blood vessel ROI. According to the invention, blood pressure measurement of ultrasonic microbubble subharmonics can be realized noninvasively, and the convenience and operability of blood pressure measurement are improved.

The invention discloses an ocean micro-plastic particle sorting and enriching integrated device and method based on bidirectional acoustic surface waves, and belongs to the crossing field of an acoustic micro-fluidic technology and ocean environment monitoring. According to the device, an inclined micro-channel design and a standing wave sound field coupling mechanism are adopted, flexible interdigital transducers which are symmetrically arranged in a sorting module are used for exciting surface acoustic waves with specific frequencies, and a high-strength sound pressure standing wave field is formed in a micro-channel. According to the particle size distribution characteristics of micro-plastic particles in the marine environment, efficient sorting of micro-plastic is achieved by accurately regulating and controlling acoustic radiation force parameters. And the sorted micro-plastics are directly introduced into the annular enrichment module, and the sound streaming effect generated by a traveling wave sound field is utilized to realize rapid enrichment of particles. According to the device, the technical bottleneck of sample transfer loss in the traditional method is overcome through the integrated design of the sorting and enriching process, and a high-sensitivity and low-cost pretreatment solution is provided for marine micro-plastic pollution monitoring.

A viscoelasticity measurement method (100, 700) and an ultrasonic measurement system (1000), the viscoelasticity measurement method (100, 700) comprising: emitting an acoustic radiation force pulse to a subject to be measured to generate a shear wave in a region of interest of the subject to be measured (S110); emitting a first ultrasonic wave to track the shear wave to the region of interest and receiving a first ultrasonic echo of the region of interest to obtain first ultrasonic echo data (S120); obtaining a shear wave signal of the region of interest from the first ultrasonic echo data (S130); extracting shear wave components of at least two different frequencies from the shear wave signal (S140); determining phase velocities of the shear wave respectively according to the shear wave components of the at least two different frequencies (S150); determining viscosity information reflecting viscosity of the region of interest according to the at least two phase velocities (S160); and outputting the viscosity information (S170). The viscosity information of the region of interest can be determined by one viscoelasticity measurement.

The invention discloses an automatic ultrasonic injector and a control method thereof. The automatic ultrasonic injector comprises a driving module, an injection module and a photonic crystal plate module, the driving module is used for providing driving force; the injection module is connected with the driving module and used for emitting ultrasonic waves and injecting liquid medicine; the injection module comprises a needle cylinder, a needle cylinder push rod, a pressure sensor and a transducer, the needle cylinder is integrally fixed on the base, the needle cylinder push rod is inserted into the tail end of the needle cylinder, and a liquid outlet is formed in the front end of the needle cylinder; the needle cylinder push rod is driven by the driving module, the front end of the needle cylinder push rod is connected with the energy converter and the pressure sensor, and the driving module drives the needle cylinder push rod, the energy converter and the pressure sensor to linearly move in the same direction in the needle cylinder; the phononic crystal plate is installed at the liquid outlet end of the needle cylinder and used for modulating the sound field, enhancing the sound radiation force and accelerating the medicine transfer efficiency. According to the invention, the medicine is permeated into the body in an ultrasonic medicine permeation manner, non-invasive in-vitro administration and targeted therapy are realized, the pain of a patient is relieved, the medicine can directly reach a focus quickly, and the infection risk is relieved.

The invention discloses a yeast cell directional sorting and gathering chip based on surface acoustic wave driving and a control system.The chip comprises a piezoelectric substrate, two interdigital electrode pairs, a micro-fluidic channel and a liquid drop residing circular ring, the first interdigital electrode pair is arranged on the two sides of the micro-fluidic channel and used for exciting a symmetrical standing wave field, and the second interdigital electrode pair is arranged on the two sides of the micro-fluidic channel and used for exciting a liquid drop residing circular ring; separating yeast cells with relatively large particle sizes from small-particle impurities through acoustic radiation force; and the second interdigital electrode pair is arranged on the two sides of the liquid drop residing circular ring, has an offset arrangement structure, and excites vortex acoustic streaming with a rotation characteristic in the liquid drop so as to realize center aggregation of target cells. The chip integrates sorting and gathering functions, has the advantages of no mark, no contact, high treatment efficiency and the like, and is suitable for the fields of biological sorting, environment detection, fermentation engineering and the like.