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Application of anwuligan or pharmaceutical composition thereof in colorectal cancer treatment

A technology of anpentapene and colorectal cancer, applied in drug combinations, medical preparations containing active ingredients, antineoplastic drugs, etc., can solve the problems of inability to effectively inhibit the M2 polarization of macrophages and unsatisfactory chemotherapy effects , to reduce colorectal cancer drug resistance, enhance chemosensitivity, and inhibit M2 polarization

Pending Publication Date: 2022-04-01
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above analysis, the embodiment of the present invention aims to provide an application of anpentapene or its drug combination in the treatment of colorectal cancer, so as to solve the problem that the existing drugs cannot effectively inhibit the M2 polarization of macrophages and the effect of chemotherapy is not effective. ideal question

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  • Application of anwuligan or pharmaceutical composition thereof in colorectal cancer treatment
  • Application of anwuligan or pharmaceutical composition thereof in colorectal cancer treatment
  • Application of anwuligan or pharmaceutical composition thereof in colorectal cancer treatment

Examples

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Embodiment 1

[0033] An embodiment of the present invention discloses an application of anpentapene in the preparation of a drug for treating colorectal cancer. The anpentapene can be used alone or in combination with existing anticancer drugs.

[0034] A large number of studies have found that anpentapene can inhibit the M2 polarization of macrophages, reduce the drug resistance of colorectal cancer induced by M2 macrophages, and enhance the chemosensitivity of colorectal cancer cells.

[0035] Preferably, the dosage of anpentapene is 5-40 mg / kg per day, 2-4 times a week, and the route of administration is oral, and the effect of inhibiting the M2 polarization of macrophages is relatively obvious.

[0036] Exemplarily, the dosage of anpentapene is 10 mg / kg, 3 times a week, 24 hours before the administration of anticancer drugs.

[0037] In order to better illustrate the effect of using anpentapene alone on macrophages in the treatment of colorectal cancer, two sets of experiments are give...

Embodiment 2

[0045] Another embodiment of the present invention discloses a drug combination for treating colorectal cancer, including drug A and drug B. Wherein, the composition of drug A includes anpentapene; the composition of drug B includes cisplatin.

[0046] Preferably, drug A is used within a preset period of time before taking drug B, so as to reduce the chemosensitivity of colorectal cancer cells to cisplatin.

[0047] It has been found through research that the combination of anpentapene and cisplatin can significantly enhance the therapeutic effect on colorectal cancer.

[0048] Preferably, the above-mentioned preset time period can be given to different people and different animals according to actual needs and experiments, and different time periods can be set, for example, one day (24 h) to one week.

[0049] Preferably, the dosage of drug A should reach the dosage of anpentapene, which is 5-40 mg / kg per day, 2-4 times a week. The route of administration is oral or intrave...

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Abstract

The invention provides application of anwuligan or a pharmaceutical composition thereof in colorectal cancer treatment, belongs to the field of colorectal cancer treatment, and solves the problems that an existing medicine cannot effectively inhibit M2 type polarization of macrophages and is not ideal in chemotherapy effect. Wherein the anwuligan can be independently used, or the anwuligan can be combined with an existing anti-cancer drug such as cis-platinum or 5-fluorouracil for use. The anwuligan can inhibit M2 type polarization of macrophages and enhance chemosensitivity of colorectal cancer cells. The anwuligan is used before the cis-platinum, or the medicine A containing the anwuligan is used before the medicine B containing the cis-platinum, the chemosensitivity of colorectal cancer cells to the cis-platinum can be reduced, the treatment effect of the cis-platinum on the colorectal cancer can be effectively improved by taking the medicine containing the cis-platinum, and the medicine has a good clinical medication development prospect.

Description

technical field [0001] The invention relates to the field of colorectal cancer treatment, in particular to an application of anpentapene or its drug combination in the treatment of colorectal cancer. Background technique [0002] Colorectal cancer is one of the most common gastrointestinal cancers, accounting for 8.5% of all cancer-related deaths worldwide, and the number of related deaths is second only to lung cancer, liver cancer and gastric cancer. At present, chemotherapy is one of the main methods for the treatment of colorectal cancer. [0003] Cisplatin is the first-line drug for colorectal cancer chemotherapy, but long-term use will lead to drug resistance in patients, which seriously affects the treatment effect of cancer and the quality of life of patients. Tumor-associated macrophages are a major component of the tumor microenvironment. Macrophages can be expressed as the M2 type that suppresses inflammation and promotes cancer, and the M1 type that promotes in...

Claims

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Application Information

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IPC IPC(8): A61K31/36A61K33/243A61K31/513A61P35/00A61P1/00
Inventor 玄延花车楠李梦轩刘兴哲崔春爱
Owner YANBIAN UNIV