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Nano particle-polymer injectable composite hydrogel double drug loading system and preparation method thereof

A composite hydrogel and nanoparticle technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of short action time and low utilization efficiency, and achieve low cost , Reasonable structural design, good biocompatibility

Active Publication Date: 2018-01-09
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a multi-drug-loaded composite material formed by coating polymer drug-loaded nanoparticles with injectable gel, which utilizes the properties and advantages of injectable gel and overcomes the low utilization efficiency of single-nanoparticle drug-loaded , short action time and other disadvantages, and has the advantages of multi-stage / gradual drug release

Method used

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  • Nano particle-polymer injectable composite hydrogel double drug loading system and preparation method thereof
  • Nano particle-polymer injectable composite hydrogel double drug loading system and preparation method thereof
  • Nano particle-polymer injectable composite hydrogel double drug loading system and preparation method thereof

Examples

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Embodiment 1

[0056] This example provides a nanoparticle-polymer injectable hydrogel composite material dual drug-loaded system, which includes nanoparticles loaded with the anticancer drug doxorubicin DOX and loaded with the anticancer drug Bray Injectable hydrogel of phosphonate disodium CA4P has two main parts. The nanoparticles are uniformly dispersed in the solution of the hydrogel-forming raw material four-arm mercapto polyethylene glycol by means of physical ultrasound. The cross-linking agent used in the synthesis of the nanoparticles is bis(2-methylpropene)ethoxy disulfide containing disulfide bonds. The synthesis of the injectable hydrogel requires the use of polymer Poly(DMA-co-PEGMA), four-arm mercapto polyethylene glycol solution, through the catechol group in the polymer chain in the oxidant NaIO 4 Under the action of the four-arm mercaptopolyethylene glycol, Michael addition occurs to the thiol groups on the four end groups to form a hydrogel with a three-dimensional space ...

Embodiment 2

[0091] This example characterizes the drug release behavior of the nanoparticle-polymer injectable hydrogel composite dual-loaded drug system prepared in Example 1. Specifically carry out characterization by following method, comprise the following steps:

[0092] Step 1: Inject 1 mL of the formed nanoparticle-polymer injectable hydrogel composite dual drug-loaded material into polycarbonate membrane (PC) In the nest, the injection volume per nest is 200 μL;

[0093] Step 2: Place the nests in step 1 above in a 24-well cell culture dish, and add 1 mL of pH 7.4 phosphate-buffered saline PBS. Place the culture dish in a 37°C incubator, take out the PBS release solution at intervals as the drug test sample, and replenish fresh PBS solution in time.

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Abstract

The invention belongs to the field of synthesis of drug carrier base materials and provides a nano particle-polymer injectable composite hydrogel double drug loading system and a preparation method thereof. The double drug loading system is loaded with not only an anti-cancer drug I of which polymer nano particles are synthesized through a disulfide bond cross-linking agent by taking acrylic acidand 4-vinylphenylboric acid as monomers, but also an anti-cancer drug II of which injectable hydrogel is synthesized through Michael addition reaction between a macromolecular cross-linking agent witha sulfhydryl functional group and a polymer containing a catechol functional group aiming at the drug loading capacity, the action time, the treatment effect and other demands. The bi-stimulus response is pH stimulus response and reducing stimulus response of glutathione to the disulfide bond cross-linking agent in a tumor cell environment respectively, the interaction between the nano particlesand the drug I as well as the degradation process of the nano particle can be affected, and the long-term delivery of the drug I is realized. The nano particle-polymer injectable composite hydrogel double drug loading system provided by the invention realizes the effects of local long-time administration, step-by-step osmotic treatment and combined treatment of a variety of drugs.

Description

technical field [0001] The invention belongs to the field of synthesis of drug carrier basic materials, in particular to a nanoparticle-macromolecule injectable composite hydrogel dual drug-loading system and a preparation method thereof. Background technique [0002] In recent years, the research of drug delivery system has made some progress in many aspects such as controlled drug release, drug targeting, enhancing drug water solubility and stability, regulating drug metabolism time, promoting drug absorption and passing through biological barriers. [0003] In terms of cancer treatment methods, the delivery of anticancer drugs through intelligent delivery systems has advantages that conventional methods do not have. side effect. Therefore, designing stimuli-responsive smart drug delivery materials is of great significance for the treatment of cancer. [0004] As a polymer with a three-dimensional network structure, hydrogel has become one of the important platforms for ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K47/58A61K31/661A61K47/34A61K9/06A61P35/00
Inventor 汪联辉杨文静梁丽君周鹏
Owner NANJING UNIV OF POSTS & TELECOMM
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