Long circulation liposome with modified integrin and carried anticancer medicine for injection

A long-circulating liposome and liposome technology, which is applied in the directions of liposome delivery, anti-tumor drugs, medical preparations of inactive ingredients, etc. less antigenic effect
CN1846691AInactive Publication Date: 2006-10-18PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PEKING UNIV
Publication Date
2006-10-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to integrin ligand modified long circulation liposome carrying anticarcinogen for injection, and is especially one kind of injected anticarcinogen carrying targeting liposome administration system. The efficient administration system is obtained through modifying the surface of liposome simultaneously with both polyethylene glycol and integrin containing arginine-glycine-asparagic acid sequence or RGD analogue.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a targeted liposome drug delivery system loaded with anticancer drugs for injection. The system uses polyethylene glycol (PEG) and A high-efficiency liposome drug delivery system obtained by modifying integrin ligands containing arginine-glycine-aspartic acid sequence (RGD) or RGD analogues. Background technique

[0002] Malignant tumors have always been an important disease that plagues human beings, and there is currently no cure for cancer. The traditional therapy for malignant solid tumors is surgical resection of the tumor followed by chemotherapy with antineoplastic drugs. Most chemotherapeutic drugs are non-selective, and these drugs also have a killing effect on normal cells while killing tumor cells, so they will produce serious side effects, such as the cardiotoxic effect of doxorubicin. Encapsulating anticancer drugs with liposomes can significant...

Claims

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