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Pharmaceutical composition for treating vascular dementia and application thereof

A technology of vascular dementia and composition, which is applied in the field of medicine, can solve the problems of poor curative effect, insufficient drugs, and many adverse reactions, and achieve the effect of excellent clinical curative effect, economic benefits, and reasonable compatibility

Pending Publication Date: 2022-04-08
NANJING XIAOZHUANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of insufficient effective treatment of vascular dementia medicines, poor curative effect, and many adverse reactions at present, and to provide a combination of stilbene glycosides, catalpol, danshensu sodium, ligustalactone I, and calamus A pharmaceutical composition made of volatile oil and polygala saponin. The pharmaceutical composition has the advantages of small dosage, good effect, complementary effects of components, and no side effects

Method used

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  • Pharmaceutical composition for treating vascular dementia and application thereof
  • Pharmaceutical composition for treating vascular dementia and application thereof
  • Pharmaceutical composition for treating vascular dementia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The sources of the components are as follows.

[0031] The preparation method of stilbene glycosides in Polygonum multiflorum: Polygonum multiflorum medicinal material coarse powder (20 mesh) is added with 12 times the amount of water, soaked for 24 hours, percolated at a flow rate of 10 mL / min per kilogram of medicinal material, and the percolation solution is placed on a macroporous resin column, 5 times The resin volume was eluted with 25% ethanol, and the eluent was recovered from the solvent, dried, and applied to a silica gel column in a dry method, and eluted with ethyl acetate-methanol-water (200:4:3). The solvent is recovered and dried to obtain the product. The yield of stilbene glycosides was 97.83%.

[0032] The preparation method of the volatile oil of Acorus calamus: Acorus calamus powder (20 mesh) and 500 times the volume of distilled water are placed in a 1000mL electric heating mantle, extracted by steam distillation for 4 hours, the obtained essential...

Embodiment 2

[0035] Preparation of a pharmaceutical composition for treating vascular dementia: Weigh 3 parts of stilbene glycosides, 1 part of catalpol, 2 parts of danshensu sodium, 5 parts of ligustalactone I, 6 parts of volatile oil of Shichangpu, polygala Saponin 2 parts. After mixing with 1.5 parts of starch, sieve and dry, add 0.1 part of magnesium stearate and 0.1 part of talcum powder, and press into tablets to obtain.

Embodiment 3

[0037] Preparation of a pharmaceutical composition for treating vascular dementia: Weigh 4 parts of stilbene glycosides, 2 parts of catalpol, 3 parts of danshensu sodium, 6 parts of ligustalactone I, 7 parts of volatile oil of Shichangpu, polygala Saponin 3 parts. After mixing with 1.9 parts of starch, sieve and dry, then add 0.12 parts of magnesium stearate and 0.12 parts of talcum powder, and fill in capsules to obtain.

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Abstract

The invention is applicable to the technical field of medicines, and provides a pharmaceutical composition for treating vascular dementia and related diseases, which comprises 1-6 parts of stibene glucoside, 0.2-4 parts of catalpol, 0.5-4 parts of salvianic acid A sodium, 3-8 parts of senkyunolide I, 3-8 parts of rhizoma acori graminei volatile oil and 0.2-5 parts of tenuifolin. The pharmaceutical composition provided by the invention is simple in formula, economical and practical, complementary to each other, reasonable in compatibility and capable of effectively treating vascular dementia. Moreover, the components are all from natural products, so that the composition has no adverse reaction and toxic and side effects after long-term use and is worthy of popularization and application. The invention also provides a preparation method of the medicinal composition, the medicinal preparation is prepared by uniformly mixing the components according to the formula ratio and mixing with pharmaceutically acceptable auxiliary materials, and the method is simple, convenient to operate and suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating vascular dementia and its application. Background technique [0002] Vascular dementia (VaD) is a dementia syndrome with cerebrovascular disease as the main cause. The prevalence rate of people over 60 years old is 1.26-2.40%, accounting for 12-20% of all dementia diseases. Cerebrovascular lesions cause cerebral ischemia, hypoxia, and hypoperfusion, followed by necrosis of local neurons in the brain, eventually leading to cognitive impairment. Vascular dementia is mainly characterized by cognitive impairment, mental behavioral symptoms, and decreased living ability, and it also has evidence-based medical evidence of cerebrovascular disease. With the aging of the population and the increase in the number of hypertensive patients in my country, reducing the incidence and disability of vascular dementia has become an urgent and important ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/28A61K31/7034A61K31/7048A61K31/192A61K31/365
Inventor 阮鸣喻斌宋孝雄邢婉青王雪晴
Owner NANJING XIAOZHUANG UNIV
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