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Synthetic method of caffeine

A synthetic method and caffeine technology, applied in the direction of organic chemistry, etc., can solve the problems of occupying a large reactor, potential safety hazards, large heat collection, etc., and achieve the effects of high efficiency in the production process, high safety assurance, and high safety factor

Pending Publication Date: 2022-04-12
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventors have developed an improved way for producing coffee beverages that contain fewer chemicals than previously used without compromising their quality or taste. This can lead to safer products while also improving productivity.

Problems solved by technology

This patented technical problem addressed in this patents involves finding ways to produce high purity caffeaimide (CAS), specifically caffee bean extract or green tea extract containing low levels of impurities such as α-,β-unsaturated carbonyl acids that may affect their quality during storage and usage in various industries like medicine, electronics industry, printing technology, detergents, plastic products manufacturing, paints, coatings, adhesives, rubber goods, lubricants, pharmaceuticals, medical devices, healthcare supplies, consumer product packaging, and others.

Method used

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  • Synthetic method of caffeine
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Experimental program
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Effect test

Embodiment 1

[0046] At room temperature, add 8g NaOH to 2000mL water, add 36g theophylline to it and stir evenly to make liquid A, add 50g dimethyl sulfate to 1630mL water to make liquid B, set the temperature of the reaction module in the reaction zone to 20°C, and use Feed pump A and feed pump B control liquid A and liquid B at a certain flow rate (keep the molar ratio of theophylline to dimethyl sulfate 1:1) at the same time into the first microchannel reaction module for mixing and reaction, and then continue Feed into 8 microchannel reaction modules connected in series to react, control the flow rate of feed pump A to be 26.2g / min, control the flow rate of feed pump B to be 10.7g / min, when there is material flow out from the outlet end of the microchannel system Finally, after waiting for the pH value of the effluent to be stable, the effluent was continuously collected for 12 minutes, combined, cooled in an ice bath for crystallization, filtered, and dried. The yield was 82.6%, and th...

Embodiment 2

[0048] At room temperature, add 16g NaOH to 2000mL water, add 36g theophylline to it and stir evenly to make liquid A, add 63g dimethyl sulfate to 2460mL tetrahydrofuran to make liquid B, set the temperature of the reaction module in the reaction zone to 50°C, respectively With feed pump A and feed pump B, A liquid and B liquid control certain flow velocity (keep theophylline and dimethyl sulfate molar ratio 1: 2.5) pass in the 1st microchannel reaction module simultaneously and mix and react, then Continue to pass into 7 microchannel reaction modules connected in series successively to react, control the flow velocity of feed pump A to be 20.9g / min, control the flow velocity of feed pump B to be 22.8g / min, when there is material at the outlet end of the microchannel system After the outflow, wait for the pH value of the effluent to be stable, collect the effluent continuously for 9 minutes, combine the effluent, concentrate under reduced pressure and evaporate the organic solv...

Embodiment 3

[0050] At room temperature, add 70g NaOH to 2000mL water, add 86g theophylline to it and stir evenly to make liquid A, add 378g dimethyl sulfate to 1420mL toluene to make liquid B, set the temperature of the reaction module in the reaction zone to 55°C, respectively With feed pump A and feed pump B, liquid A and liquid B are controlled to a certain flow rate (keep theophylline and dimethyl sulfate molar ratio 1:3) and pass into the first microchannel reaction module to mix and react at the same time, then Continue to pass into 6 microchannel reaction modules connected in series successively to react, control the flow velocity of feed pump A to be 25.4g / min, control the flow velocity of feed pump B to be 9.1g / min, when there is material at the outlet end of the microchannel system After the outflow, wait for the pH value of the effluent to be stable, collect the effluent continuously for 10 minutes, combine the effluent, concentrate under reduced pressure and evaporate the organ...

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Abstract

The invention provides a synthetic method of caffeine, and relates to the technical field of chemical synthesis. The synthetic method of caffeine comprises the following steps: (a) adding theophylline into an alkaline solution to prepare an alkaline solution of theophylline salt; and (b) simultaneously introducing an alkali solution of theophylline salt and a methylation reagent into the micro-channel reactor at a certain flow rate respectively, mixing the alkali solution of theophylline salt and the methylation reagent in the micro-channel reactor, and carrying out methylation reaction to obtain caffeine. According to the present invention, by accurately controlling each reaction material, the pH value does not need to be adjusted by repeatedly supplementing alkali during the reaction process, such that the tedious operation is avoided, the generation of the waste liquid is reduced, the occupation of the large number of the reaction kettles is not needed, the whole reaction process is the continuous reaction, and the mass transfer efficiency, the reaction speed, the heat dissipation speed and the safety coefficient during the reaction process are high.

Description

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Claims

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Application Information

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Owner TIANJIN PHARMA GROUP CORP
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