Genetic pharmacopoeia for comprehensive functional analysis of human cancer

Abstract

Described herein are genetic pharmacopoeia for querying for individual cancer susceptibility to available molecular targeted therapies.

Description

[0001] cross reference [0002] This application claims the benefit of U.S. Provisional Patent Application Serial No. 62 / 865,047, filed June 21, 2019, which is hereby incorporated by reference in its entirety. [0003] sequence listing [0004] This application contains a Sequence Listing, which has been filed electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on June 18, 2020, is named 56322-701_601_SL.txt and is 732,058 bytes long. Background technique [0005] Human cancers are very heterogeneous, differing at the DNA sequence, epigenomic landscape, RNA expression, and protein levels, resulting in enormous combinatorial complexity in cellular behavior. Despite impressive advances in our medical devices for molecularly-targeted anticancer therapies, the extreme molecular complexity underlying cancer cell behavior has left us with significant inadequacies in our ability to predict which patients will benefit f...

AI Technical Summary

Problems solved by technology

Despite impressive advances in our medical devices for molecularly-targeted anticancer therapies, the extreme molecular complexity underlying cancer cell behavior has left us with significant inadequacies in our ability to predict which patients will benefit from any particular therapy

Lack of effective means of predicting patient response directly leads to ineffective treatment cycles, with substantial opportunity costs for patients and significant economic costs for patients and healthcare payers

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