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Application of pulsatilla saponin B5 in preparation of medicine for treating impotence

The technology of Pulsatilla saponin and medicine is applied in the field of medicine and health, and can solve the problems of priapism, reduce anticoagulation effect, expensive treatment effect and the like, and achieve the effects of low cost of medicine, reduction of riding latency and easy use.

Active Publication Date: 2022-05-13
广西馨海药业科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used injection and oral drugs include prostaglandin E1, E2, moxicelib, testosterone, calcitonin peptide, apomorphine, sildenafil, etc., although it can improve the erection effect to a certain extent, but there is an injection site Pain and hematoma, transient hypotension, drowsiness, dizziness, headache, vasodilation flushing, dry mouth, sinus node block, epistaxis or gingival bleeding, prolongation of coagulation time, combined with antiplatelet drugs can reduce its resistance Blood clotting, side effects such as hair loss, abdominal pain, diarrhea or nausea, priapism
Although there are many drugs currently used for the treatment of ED, most of them are expensive and the therapeutic effect is not satisfactory. Therefore, there is an urgent need for a drug for the treatment of impotence with low cost, easy to use, non-invasive operation, small side effects and long-lasting curative effect.

Method used

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  • Application of pulsatilla saponin B5 in preparation of medicine for treating impotence
  • Application of pulsatilla saponin B5 in preparation of medicine for treating impotence
  • Application of pulsatilla saponin B5 in preparation of medicine for treating impotence

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Experimental animals: purchased from China National Institutes for Food and Drug Control (Daxing), SD rats, male, 180-200g, SPF grade, production license number: SYXK2017 (Beijing)-0005. In the Experimental Animal Center of the Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, they were bred in a barrier environment, license number SYXK (Beijing) 2019-0003.

[0031] Experimental reagents and drugs: Pulsatilla saponin B5, donated by Guangxi Inluvit Pharmaceutical Co., Ltd.; Sildenafil Citrate Tablets, Qilu Pharmaceutical Co., Ltd., product batch number: 1E0022081.

[0032] Experimental method (modeling and drug administration method): The classic vascular ED rat model was used, and the iliac vessels were exposed through a median abdominal incision. The iliac veins were carefully separated under the operating microscope until the internal iliac arteries were exposed, and then the bilateral internal iliac vessels were liga...

Embodiment approach 1

[0050] Embodiment 1: Emulsion or cream with Pulsatilla saponin B5 as the active ingredient;

[0051] Usually, what is semi-solid at room temperature is called cream, and what is called fluid state is called milk or emulsion. Emulsion is two kinds of liquids that are not compatible with each other, and one phase is dispersed in the other phase with tiny droplets. In the system formed in the system, one phase in the form of liquid droplets is usually called the dispersed phase or the internal phase, and the other phase is called the dispersion medium or the external phase.

[0052] Commonly used excipients for emulsions or creams are: emulsifiers, antioxidants, thickeners, pH regulators, and oily ingredients.

[0053] Emulsifier: In order to form a stable emulsion, the addition of emulsifier is necessary.

[0054] pH regulator: In order to avoid excessive irritation and stabilize the drug, a buffer solution is often used to stabilize the pH of the drug solution. Commonly used ...

Embodiment approach 2

[0057] Embodiment 2: an oral liquid with Pulsatilla saponin B5 as the active ingredient;

[0058] Taking oral liquid as an example, oral liquid is a new dosage form developed on the basis of decoction and injection. It has the advantages of small dose, fast absorption, stable quality, convenient carrying and taking, and easy storage. It contains a variety of active ingredients. Makes a big difference in quality and taste. Without changing the structure and function of the main active ingredients, how to retain the active ingredients to the greatest extent and improve the taste is a difficult point in the selection of excipients. Adding excipients in oral liquid can improve taste, clarity, stability and product quality.

[0059] Commonly used excipients for oral liquids include: solvents, fragrances, flavoring agents, clarifiers, preservatives, etc. These excipients can be added at the same time, or one of them can be added. Among them, the solvent must be added, and water can...

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Abstract

The invention discloses an application of pulsatilla saponin B5 in preparation of a medicine for treating impotence. Experiments show that the pulsatilla saponin B5 obviously reduces the riding latency period of an impotence animal model, increases the number of riding times, enhances sex indexes, improves the muscle tension of erectile penis cavernosum after impotence modeling, and increases the amplitude and phase number of an electromyogram after erection of the penis. Therefore, the pulsatilla saponin B5 can be applied to preparation of the medicine for treating the impotence.

Description

technical field [0001] The invention relates to the field of medicine and health, in particular to the application of Pulsatilla saponin B5 in the preparation of medicaments for treating impotence. Background technique [0002] Impotence, also known as erectile dysfunction (Erectile dysfunction, ED), refers to the continuous inability of the penis to achieve or maintain a sufficient erection to obtain a satisfactory sexual life, and the onset time is at least more than 3 months. ED is a common medical problem that is reported to affect approximately 100 million men worldwide. Treatment options include: syringe self-administration, oral medication, arteriovenous surgery, dildo implants, and vacuum compressor. Among them, the first two methods are simple to operate and have relatively small side effects, which are easy to be accepted by patients. Commonly used injection and oral drugs include prostaglandin E1, E2, moxicelib, testosterone, calcitonin peptide, apomorphine, sil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P15/10
CPCA61K31/704A61P15/10
Inventor 杨世林郭秋岩高红伟王继刚
Owner 广西馨海药业科技有限公司
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