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Multi-brain-region co-activation mode research method for teenager muscular spasm epilepsy

A technique of activation patterns, myoclonus, applied in the field of neuroimaging to resolve discrepancies, etc.

Pending Publication Date: 2022-06-28
LANZHOU UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

This method decomposes a large amount of resting-state data into 30 CAPs by selectively averaging individual fMRI time frames, reflecting patterns across the population but differing significantly from results obtained using methods such as ICA

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  • Multi-brain-region co-activation mode research method for teenager muscular spasm epilepsy
  • Multi-brain-region co-activation mode research method for teenager muscular spasm epilepsy
  • Multi-brain-region co-activation mode research method for teenager muscular spasm epilepsy

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Embodiment Construction

[0056] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0057] research object

[0058] The data used in this study came from the Second People's Hospital of Lanzhou University, with a total of 54 cases, including 27 patients with juvenile myoclonic epilepsy, including 15 males and 12 females, with an average age of 17.593 years; 27 normal controls, of which There were 12 males and 15 females with an average age of 19.667 years. Both the patient group and the normal control group were right-handed. The intra-group paired FDR test showed that there was no significant difference in gender and age between the two groups (p>0.05FDR-corrected). All patients were diagnosed ...

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Abstract

The invention belongs to the technical field of neuroimaging, and particularly relates to a research method for a teenager muscular spasm epilepsy multi-brain-region co-activation mode. The method comprises the following steps: firstly, analyzing the grey matter volume of a JME patient by utilizing voxel-based morphological analysis (VBM); it is assumed that a brain region with gray matter volume atrophy is a key brain region causing disease generation, so that the brain region with gray matter volume atrophy is used as a region of interest, and brain dynamic activity changes of a JME patient and a healthy control group in the selected region of interest are analyzed through a co-activation mode. Therefore, the difference between the dynamic brain activities of the JME patient and the normal person in the resting state can be searched.

Description

technical field [0001] The invention belongs to the technical field of neuroimaging, and in particular relates to a research method for the co-activation pattern of multiple brain regions in juvenile myoclonic epilepsy. Background technique [0002] The human brain is composed of multiple large-scale functional networks with different functions. The functional activities of several brain regions contained in each functional network are synchronized in the resting state, and different functional networks show different performances. Active mode. In order to deeply understand the working mechanism of the brain and explore the pathophysiological mechanisms of various brain diseases, researchers need to analyze functional brain network connectivity from the perspective of functional integration. Functional connectivity (FC) reflects the relationship between various brain regions. The synchrony of spontaneous neuronal activity has been studied in various neurological diseases, p...

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Application Information

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IPC IPC(8): G06T7/00G06T7/30G16H30/20G16H50/20G06K9/62G06V10/25G06V10/762
CPCG06T7/0012G06T7/30G16H50/20G16H30/20G06T2207/30016G06T2207/20104G06T2207/10088G06F18/23213
Inventor 柯铭刘光耀候磊
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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