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Application of ketanserin and glycyrrhizic acid in preparation of medicine for treating pain

A technology of glycyrrhizic acid and ketanserin, which is applied in the field of pain medicine, can solve chronic pain problems such as lack of treatment options, poor effect, and addiction

Pending Publication Date: 2022-07-08
YANAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, clinical analgesic drugs such as morphine and non-steroidal anti-inflammatory drugs have problems such as poor effect, high toxicity and side effects, and addiction, resulting in the lack of effective treatment options for chronic pain in clinical practice.

Method used

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  • Application of ketanserin and glycyrrhizic acid in preparation of medicine for treating pain
  • Application of ketanserin and glycyrrhizic acid in preparation of medicine for treating pain
  • Application of ketanserin and glycyrrhizic acid in preparation of medicine for treating pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Observation of ketanserin and glycyrrhizic acid in alleviating spontaneous pain-related behaviors in rats

[0025] The administration method is as follows: 30 minutes before the injection of scorpion toxin in 4 groups of rats (5 rats in each group, body weight 200±20g, numbered 1#, 2#, 3#, 4#), in the 1# rat sheath 10 μl 5% DMSO was injected intrathecally, 50 μg ketanserin was intrathecally injected into the 2# rat, 10 μg glycyrrhizic acid was intrathecally injected into the 3# rat, and 50 μg ketanserin and 10 μg glycyrrhizic acid were intrathecally injected into the 4# rat. Put a stand with a height of 75cm on the table covered with a glass mirror, and place a 20×20×30cm on the shelf 3 Transparent plexiglass box, put the rat into the plexiglass box, and observe the reaction of the rat's foot after administration from the mirror on the table. Before the start of the experiment, the rats were placed in a transparent plexiglass box for 30 minutes to adapt to the experime...

Embodiment 2

[0028] Observation of ketanserin and glycyrrhizic acid in relieving bilateral mechanical hyperalgesia in rats

[0029] After the spontaneous pain basically disappeared in Example 1, the rats were placed on a 20 × 20 × 30 cm grid on a 1 cm × 1 cm steel wire grid. 3 Transparent plexiglass box for 30min to adapt to the experimental environment. Von Frey fiber (58011, Stoelting Co., USA) (0.6-26g) was used to measure the mechanical withdrawal reflex threshold, 50 μg ketanserin was injected intrathecally in the 2# rat, and 10 μg glycyrrhizic acid was intrathecally injected in the 3# rat, 4# rats were intrathecally injected with 50 μg ketanserin and 10 μg glycyrrhizic acid. After the injection, the rats were measured when the hind paw of the injected side touched the ground and was bearing normal weight. Stimulate the central skin of the animal's bilateral hind limbs from under the grid. The interval between two measurements is 20 seconds. The stimulation intensity of Von Frey fibe...

Embodiment 3

[0031] Observation of ketanserin and glycyrrhizic acid in relieving heat hyperalgesia in rats

[0032] After the spontaneous pain basically disappeared in Example 1, the 20 × 20 × 30 cm 3 The plexiglass cover was placed on a glass plate with a thickness of 2 mm, and the rat was placed in it. Below the glass was the infrared photothermal probe of the thermal pain stimulator (PL-200, Chengdu Taimeng Technology Fume Co., Ltd.). Radiant thermal stimulation was applied directly to the center of the hind paws of the rats. An automatic cutoff time of 20 seconds was measured to avoid tissue damage. The same site was repeatedly measured for 5 times, with an interval of at least 10 min between each measurement, and the interval between two measurements at different sites was 5 min, five times, and the average value was taken as the thermal contraction reflex threshold. In this way, a baseline test is performed the day before the experiment. The thermal pain threshold was collected at...

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Abstract

The invention discloses an application of ketanserin and glycyrrhizic acid in preparation of a medicine for treating pain, a BmK I mirror image pain model constructed by natural scorpion fish is adopted to simulate clinical common symptoms of spontaneous pain, heat pain sensitivity and mechanical pain sensitivity, so that ketanserin and glycyrrhizic acid have inhibition effects on spontaneous pain, heat pain sensitivity and mechanical pain sensitivity, and the application of ketanserin and glycyrrhizic acid in preparation of a medicine for treating pain is realized. The compound can be used as a novel drug target for treating pain.

Description

technical field [0001] The invention belongs to the technical field of medicines for treating pain, and relates to the application of ketanserin and glycyrrhizic acid in the preparation of medicines for treating pain. Background technique [0002] Pain is an unpleasant emotional experience caused by noxious stimuli, which has become a common clinical symptom and causes great distress to patients. Physiological pain has a short duration, which is an indispensable self-protection mechanism of the body and an early warning signal when the body avoids potential threats; while pathological pain is a common feature of most diseases, with long duration, slow recovery, and onset. The mechanism is complex, which leads to the disorder of the patient's body function, causes secondary damage to the patient, and affects people's quality of life and health. It has become a clinical disease. Pain affects more than 35% of the world's population every year, placing a huge financial burden o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/517A61P29/00
CPCA61K31/704A61K31/517A61P29/00A61K2300/00
Inventor 杨清湖白占涛魏倩杨亮姜鸣刘霞
Owner YANAN UNIV
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