Application of aldenafil citrate in preparation of medicine for preventing and/or treating pulmonary arterial hypertension
A technology of pulmonary arterial hypertension and citric acid, which is applied in the field of preparation of edenafil citrate for the prevention and treatment of pulmonary arterial hypertension, and can solve problems such as unsatisfactory treatment effects
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[0039] Example 1
[0040] In this example, from the perspective of preventing pulmonary arterial hypertension, a rat model of pulmonary arterial hypertension was established, and a preventive drug regimen was implemented.
[0041]EXAMPLES Animals 70 SPF SD rats with a body weight of 200-220 g were randomly divided into 7 groups with 10 rats in each group. The above 7 groups were set as normal control group, pulmonary hypertension model group and positive drug sildenafil group respectively. (30 mg / kg, oral administration, once a day), positive drug bosentan group (100 mg / kg, oral administration, once a day), edenafil citrate low-dose group (15 mg / kg, oral administration , once a day), edenafil citrate medium-dose group (30 mg / kg, orally, once a day) and edenafil citrate high-dose group (60 mg / kg, orally, once a day) . At the beginning of the experiment, except for the normal control group, which was given an equal amount of normal saline, other animals were given 50 mg / kg of ...
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[0049] Example 2
[0050] In this example, from the perspective of preventing pulmonary arterial hypertension, the effect of aldenafil citrate on the survival rate of pulmonary arterial hypertension model rats was studied.
[0051] At the end of the experiment, the death of animals was counted. The results are shown in Table 1, 2 animals died in the model group, and there was no animal death in the blank group and each administration group, indicating that the administration of idinafil citrate can delay the development of pulmonary hypertension and play a preventive role. while reducing mortality.
[0052] Table 1 Survival rate of rats at the end of the preventive effect experiment
[0053]
Example Embodiment
[0054] Example 3
[0055] In this example, from the perspective of preventing pulmonary arterial hypertension, the effects of aldenafil citrate on cardiac function, right ventricular systolic pressure and right ventricular remodeling in pulmonary arterial hypertension model rats were studied.
[0056] At the end of the experiment, the rats were anesthetized with chloral hydrate, their limbs and heads were fixed on the mouse plate, and the animal body temperature was maintained by turning on the heating plate. The needle electrodes were subcutaneously inserted into the front and rear limbs, and the ECG changes in lead II were observed and recorded for 3 minutes.
[0057] On the basis of the existing neck incision in the rat, the right neck muscle was further exposed, the tissue was bluntly separated, the external jugular vein of about 1 cm in length was freed, 2 sutures were embedded, the distal end was ligated, and the proximal end was cut. V"-shaped incision, slowly push the...
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