Compact ion guide driving device and automatic radio frequency tuning method, equipment and medium thereof

Abstract

The invention relates to a compact ion guide driving device, an automatic radio frequency tuning method and equipment thereof, and a medium. The method comprises the following steps: acquiring a resonant frequency estimated value; determining an initial interval of resonant frequency searching; setting a radio frequency driving initial control quantity; the DDS output frequency is converted according to the frequency stepping value; recording the corresponding detection current value and judging whether the detection current value is smaller than a preset current value, if so, adjusting the interval endpoint through the change trend of the detection current value to obtain a new interval, and otherwise, reducing the initial control quantity; and if the width of the new interval reaches a set target, taking the midpoint of the new interval as a set value of the output resonant frequency of the DDS frequency generation module. The requirement of more channels of the driving circuit is met, the device is compact, the miniaturization of the mass spectrometer is promoted, and the application scene is expanded; output program control and feedback monitoring of the driving device are achieved, and flexibility and reliability are improved.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry ion guidance, in particular to a compact ion guidance drive device and an automatic radio frequency tuning method, equipment and medium thereof. Background technique [0002] Mass spectrometer is a high-end scientific instrument that is widely used in various disciplines to identify compounds by preparing, separating, and detecting gas-phase ions. It has extremely broad applications in environmental testing, homeland security, clinical analysis, organic synthesis, drug discovery, protein and metabolomics, and more. [0003] At present, electrospray in almost all commercial instruments works at atmospheric pressure or near atmospheric pressure, while mass spectrometers require a high degree of vacuum, so a series of vacuum interfaces and ion guide devices are required to make the ions generated by electrospray. can enter the analyzer. [0004] Due to the atmospheric pressure vacuum inte...

AI Technical Summary

Problems solved by technology

[0006] With the development of ion guide technology, more complex combined ion focusing guide devices such as multi-stage ion funnels are continuously produced, which requires more channels for the corresponding drive circuit. At present, there is no design to meet various types of guides. The ion guide driving device of the guide mechanism limits the flexibility of the device

In addition, due to defects in the current principle and PCB design, connector selection and chassis structure design, the existing ion guide drive device has not been fully compacted, resulting in the inability to promote the miniaturization of the mass spectrometer, and the device can be tested Low reliability and maintainability, which limits the expansion of its applicable scenarios

Finally, there is currently no system solution for automatic radio frequency tuning of the ion guide drive device and real-time monitoring and early warning of the operating resonance current, which limits the safety and reliability of this type of system during use

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