Application of chiral nano bionic photosensitive protein in preparation of medicine for promoting regeneration of damaged neuron axons

A nano-biomimetic, light-sensitive protein technology, applied in the preparation of drugs for promoting the regeneration of damaged neuron axons, in the field of chiral nano-biomimetic light-sensitive proteins, can solve problems such as lack of internal mechanisms, and achieve the goal of relieving central nervous system damage and diseases. Effect
CN114832104AActive Publication Date: 2022-08-02JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2022-08-02

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Abstract

The invention relates to application of chiral nano bionic photosensitive protein in preparation of a medicine for promoting regeneration of axons of damaged neurons. Chiral nickel hydroxide ultra-small nanoparticles with characteristics similar to photosensitive protein are utilized, can penetrate through a blood brain barrier, enter damaged neuronal cells in the brain of an AD mouse and are combined with a cell membrane receptor, calcium ion flow is caused under the action of near-infrared light, and then a Wnt5a / JNK pathway is activated. Through illumination treatment for two months, the expression quantities of RhoA and ROCK in the brain of the AD mouse are reduced, axons of damaged neurons regrow, meanwhile, the content of marker protein in cerebrospinal fluid of the AD mouse is reduced, and the memory and cognitive abilities are recovered. The method can be applied to neuronal repair of AD model mice, and provides possibility for relieving central nervous system diseases such as neuronal injury.
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Description

technical field

[0001] The invention relates to the technical field of material chemistry, in particular to the application of a chiral nanometer biomimetic light-sensitive protein in the preparation of a drug for promoting regeneration of damaged neuron axons. Background technique

[0002] Neurons are the basic units of the structure and function of the nervous system, regulating and controlling the life activities and health of the human body. Once damaged, it will cause permanent damage to the brain, resulting in motor, memory and cognitive dysfunction, and repair and regeneration of damaged neurons. Essential for maintaining normal neural activity. Therefore, establishing a feasible method that can enhance the intrinsic regenerative ability of neurons and enable the regeneration and functional recovery of damaged neuron axons has great application prospects in alleviating central nervous system injury diseases such as Alzheimer's disease. In recent years, with the devel...

Claims

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