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Antibacterial and bone repair promoting hydrogel based on carbon quantum dots as well as preparation method and application of antibacterial and bone repair promoting hydrogel

A technology for carbon quantum dots and water repair. It is applied in nano-carbon, prosthesis, nanotechnology and other directions. It can solve the problems that ROS cannot identify bacteria and cells, limit application, tissue damage, etc., achieve good biocompatibility, promote bone The effect of tissue repair and promotion of osteogenic differentiation

Pending Publication Date: 2022-08-09
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although various materials can achieve the purpose of removing bacteria by producing ROS (reactive oxygen species, active oxygen radicals), the ROS produced cannot recognize bacteria and cells, so while killing bacteria, it will also cause damage to surrounding tissues. damage, thus limiting the further application of such materials in the repair of infected bone injuries

Method used

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  • Antibacterial and bone repair promoting hydrogel based on carbon quantum dots as well as preparation method and application of antibacterial and bone repair promoting hydrogel
  • Antibacterial and bone repair promoting hydrogel based on carbon quantum dots as well as preparation method and application of antibacterial and bone repair promoting hydrogel
  • Antibacterial and bone repair promoting hydrogel based on carbon quantum dots as well as preparation method and application of antibacterial and bone repair promoting hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of this embodiment CQD / HA / Gelma composite hydrogel, including the following steps:

[0037] S11: Give 500mg of arginine powder at 240 ° C for 3h, and then cooled to room temperature naturally, dissolved the sarcinicine powder in the super pure water. Add MWCO = 1000DA's dialysis bag in the ultra-pure water dialysis 24h, and finally get ARG-CQD nanoparticles after frozen and dry; figure 1 The results show that ARG-CQD is a circular nanoparticles with average particle size with a particle size of about 6nm.

[0038] S12: Take 1.5g HA to dissolve in 150ml to remove ionic water, then add 802 mg of potassium permanganate and stir at room temperature for 2h, then add 200 μL of ethylene glycol to terminate the reaction, and then add the reaction solution to the dialysis bag of MWCO = 8000da in the ion. The dialysis in the water is 72h, and finally the HA-Cho is obtained by freezing and drying; figure 2 The results show that in 1731cm -1 The obvious -cho abso...

Embodiment 2

[0043] The preparation method of this embodiment CQD / HA / Gelma composite hydrogel, including the following steps:

[0044]S21, weigh 500mg of arginine powder at 240 ° C, burn for 3h, and then cooled to room temperature naturally, dissolved the sarcinicine powder in the ultrasonic 30min, and centrifuged 30min at 15000rpm, and then the top will be topped up. Add MWCO = 1000DA's dialysis bag in the ultra-pure water dialysis 24h, and finally get ARG-CQD nanoparticles after frozen and dry;

[0045] S22, weigh 1.5g HA in 150ml to remove ionic water, then add 802 mg of potassium permanganate and stir at room temperature for 2h, then add 200 μL of ethylene glycol to terminate the reaction, and then add the reaction solution to the dialysis bag of MWCO = 8000da in the ion. The dialysis in the water is 72h, and finally the HA-CHO is obtained by freezing and drying;

[0046] S23, weigh 1G GELMA and 50mg Lap (Lithium Phenyl-2,4,6-Trimethyl-Benzoylphosphinate, benzene (2,4,6-trimethyl benzohyl)...

Embodiment 3

[0049] The preparation method of this embodiment CQD / HA / Gelma composite hydrogel, including the following steps:

[0050] S31, weigh 500mg of arginine powder at 240 ° C, burn for 3h, and then cooled to room temperature naturally, dissolved the burning arginine powder in ultrasonic water for 30 minutes, then centrifuged 30min at 15000rpm, and then the top will be topped up. Add MWCO = 1000DA's dialysis bag in the ultra-pure water dialysis 24h, and finally get ARG-CQD nanoparticles after frozen and dry;

[0051] S32, which is said to be 1.5gha to dissolve in 150ml to remove ionic water, then add 802 mg of potassium permanganate and stir at room temperature for 2h, then add 200 μL of ethylene glycol to terminate the reaction, and then add the reaction solution to the dialysis bag of MWCO = 8000da in the dehumin water water in the ion water water Dialysis 72H, finally get HA-CHO after frozen and dry;

[0052] S33, called 1g Gelma and 50mg Lap (Lithium Phenyl-2,4,6-Trimethyl-Benzoylpho...

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Abstract

The invention provides antibacterial and bone repair promoting hydrogel based on carbon quantum dots as well as a preparation method and application of the antibacterial and bone repair promoting hydrogel. The composite hydrogel comprises Arg-QD, HA-CHO (oxidized hyaluronic acid) and GelMA (methacrylated gelatin), the CQD / HA / GelMA composite hydrogel has good biocompatibility, Arg-QD nanoparticles can be released in response to an infectious bone injury microenvironment, continuous sterilization is achieved, bone tissue repair is promoted, and the CQD / HA / GelMA composite hydrogel can be used as an excellent infectious bone injury repair material for bone tissue engineering.

Description

Technical field [0001] The present invention is a technology in the field of biomedical materials, and especially involves a carbon quantum -based antibacterial and bone -promoting hydrogel and its preparation methods and applications. Background technique [0002] Infection is the main cause of bone implantation failure. Orthopedic implant -related infections are mainly caused by Golden Bacizilus, and will delay the healing process, leading to bone loss, which requires extensive surgical intervention and long -term antibiotic therapy. However, repeated antibiotic therapy increases the possibility of drug resistance (40 % of the pathogenic glyphobacter bacteria is metharocioxylin -resistant). These infections often cause implants failure, need to replace the implant, and cause chronic and / or recurrence diseases. In addition to severe infection caused by pain and economic losses in further treatment, it may also lead to amputation or fatal sepsis. At present, the optimization of b...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/22A61L27/08A61L27/54A61L27/52A61L27/58C01B32/15B82Y40/00
CPCA61L27/20A61L27/222A61L27/08A61L27/54A61L27/52A61L27/58C01B32/15B82Y40/00A61L2300/108A61L2300/404A61L2300/412A61L2400/12A61L2430/02C08L5/08C08L89/00
Inventor 李斌李家颖韩凤选
Owner SUZHOU UNIV
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