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Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method

A technology of compound traditional Chinese medicine and paeoniflorin, which is applied in the directions of drug combination, carbohydrate active ingredients, sexual diseases, etc., can solve the problem of slowing down the elimination rate of phenytoin, and achieve the enhancement of pharmacological action and clinical efficacy, and improvement of traditional Chinese medicine. The effect of increasing the degree of

Inactive Publication Date: 2004-06-30
CHONGQING LUMMY PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, the elimination rate of phenytoin was significantly slowed down in the experimental group

Method used

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  • Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method
  • Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method
  • Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method

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example 1

[0036] The present invention will be described in further detail below in conjunction with illustrations and examples. Example 1. Use the Chinese medicine compound extract of the present invention and the contrast to carry out the mensuration of the paeoniflorin concentration in the blood after the rabbit gavage with the compound extract of peony and licorice

[0037] 1 test purpose: by the mensuration of blood drug concentration after gavage to New Zealand white rabbit, research compound prescription of the present invention

[0038] Effects of piperine in traditional Chinese medicine extracts on gastrointestinal absorption and plasma concentration of paeoniflorin.

[0039] 1.2 Test materials: New Zealand white rabbits were provided by the Experimental Animal Center of West China Medical Campus, Sichuan University, male, weighing 1.8-2.0 kg. The content of paeoniflorin in the compound traditional Chinese medicine extract of the present invention prepared by the inventor and ...

example 2

[0064] Example 2. Extraction process of piperine

[0065]2.1 Purpose: To extract high-purity piperine from black pepper with an optimized process.

[0066] 2.2 Methods and results: 200g of Hainan pepper seeds were crushed and extracted twice with 95% ethanol at room temperature, each time for 2 days. The extract was concentrated under reduced pressure, and after ethanol was removed, the extract was dissolved in ether, washed twice with 5% aqueous sodium hydroxide solution, and then washed twice with water. Concentrate the ether portion under reduced pressure, disperse the extract in water, extract 6 times with ethyl acetate, combine the ethyl acetate portion, concentrate to dryness, and crystallize from methanol to obtain 5 g of crude piperine, with a yield of 2.5%.

[0067] The product was compared with the piperine standard by TLC and developed with 3 different developing agents, the Rf values ​​of the two were the same; the molecular weight determined by ESI-MS was m / z: 28...

example 3

[0071] Example 3. Extraction process of peony licorice compound

[0072] 3.1 Purpose: To prepare the compound extract of peony and licorice, the content of paeoniflorin is required to be 55%, and the content of paeoniflorin: glycyrrhizic acid is 10:1 (weight ratio)

[0073] 3.2 Materials: Paeoniflorin standard product and glycyrrhizic acid standard product were purchased from Sichuan Drug Control Institute; two batches of Chuanbai Paeoniae Alba and Northeast Licorice were purchased from Hehuachi Traditional Chinese Medicine Market in Chengdu. It was identified that two batches of Radix Chuanbai and Northeast Licorice belonged to the same genus. The contents of paeoniflorin in the first and second batches of Chuanbai Paeoniae Alba were 2.10% and 5.74%, respectively, and the contents of glycyrrhizic acid in the first and second batches of Northeast Licorice were 2.96% and 4.30%, respectively, as detected by HPLC.

[0074] 3.3 Methods and results:

[0075] 3.3.1 Mixed extractio...

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Abstract

In oral compound Chinese medicine preparation, piperine can improve the absorption of paeoniflorin in gastrointestinal tract, increase the concentration of paeoniflorin in blood and raise the biological utilization of paeoniflorin. One typical compound Chinese medicine is paeoniae licorice decoction comprising Radix Paeoniae Alba, licorice and pepper for treating women's lower abdomen pain caused by vital energy stagnation and blood stasis. The preparation process of the present invention ensures the control of the content of different effective components in the medicine preparation.

Description

Technical field: [0001] The invention relates to a compound traditional Chinese medicine which uses piperine to increase the bioavailability of paeoniflorin and its preparation method Background technique: [0002] Various gynecological diseases, such as dysmenorrhea, acute and chronic pelvic inflammatory disease, uterine fibroids, and endometriosis, all have lower abdominal pain and inflammation to varying degrees. [0003] Traditional Chinese medicine theory believes that lower abdomen pain is related to body factors and physiological environment, and the syndromes are mostly qi stagnation and blood stasis, and weak spleen and stomach elements. And the less abdomen is the path of the Liver Meridian, the Qi desires to move but the Liver does not respond, and when the Qi is brushed, pain arises. [0004] The ancient prescription Shaoyao Gancao Decoction in "Treatise on Febrile Diseases" is a good prescription for treating lower abdomen pain. The monarch drug of the prescri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/70A61P15/00
Inventor 唐小海
Owner CHONGQING LUMMY PHARMA
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