Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Process extracting purified danshen extract from red sage root

A technology of Danshensu and Danshen, applied in the separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problem of low production capacity

Inactive Publication Date: 2004-08-11
EAST CHINA UNIV OF SCI & TECH +1
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved in the present invention is to provide a method for extracting and purifying Danshensu from the plant Salvia miltiorrhiza, to overcome the defect of low production capacity in the prior art, so as to facilitate large-scale purification of Danshensu

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Process extracting purified danshen extract from red sage root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1.5 kg of traditional Chinese medicine Salvia miltiorrhiza is extracted with 15 kg of water, and the extract flows through an adsorption column filled with 200 ml of strong basic resin 717 for adsorption. The diameter of the adsorption column is 30 mm, and the flow rate is 10 times the resin volume per hour. After the extract has flowed out, use 400 ml of 4% sodium hydroxide eluent to elute at a rate of 2 times the volume of the resin per hour to obtain 420 ml of eluate, adjust the pH of the eluent to 5 and then add 850 ml Ethyl acetate is used for extraction, and then the organic solvent containing danshensu is vacuum-concentrated to recover the solvent to obtain 13 grams of danshensu product, containing 31% of danshensu.

Embodiment 2

[0023] After 5 kilograms of Chinese medicine salvia miltiorrhiza was extracted with 50 kilograms of water, the extract flowed through an adsorption column (80 millimeters in diameter) filled with 2000 milliliters of HZ802 adsorption resin and an adsorption column (30 millimeters in diameter) filled with 400 milliliters of 717 ion exchange resin respectively. The flow rate is 4 liters per hour. After the extract has flowed out, use 3000 ml of 1% sodium hydroxide eluent to elute the HZ802 adsorbent at a rate of 2 times the volume of the resin per hour. Use 800 milliliters of 10% sodium chloride to elute the 717 resin at a rate of 2 times the resin volume per hour to obtain 850 milliliters of eluent. After adjusting the pH of this eluent to 3, add 1800 milliliters of ethyl acetate for extraction. Then the ethyl acetate solution containing danshensu was vacuum concentrated and crystallized to obtain 28 grams of danshensu product, containing 52% of danshensu.

Embodiment 3

[0025] After 5 kg of traditional Chinese medicine Salvia miltiorrhiza was extracted with 50 kg of water, the extract flowed through an adsorption column (80 mm in diameter) filled with 2000 ml of HZ802 adsorption resin and an adsorption column (30 mm in diameter) filled with 400 ml of D201×2 ion exchange resin respectively. ) at a flow rate of 4 liters per hour. After the extract has flowed out, use 3000 ml of 1% sodium hydroxide eluent to elute the HZ802 adsorbent at a rate of 2 times the volume of the resin per hour. Use 800 milliliters of 10% sodium chloride to elute the D201×2 resin at a rate of 2 times the volume of the resin per hour to obtain 880 milliliters of eluent. After adjusting the pH of this eluent to 3, add 2000 milliliters of ether for extraction. Then the ether solution containing danshensu is vacuum concentrated and crystallized to obtain 12 grams of danshensu product, containing 91% of danshensu.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for extracting purified danshen extract from red sage root includes adsorptive separation by polar resin or ion exchange resin, and extracting high-purity danshen extract from the eluant by organic solvent.

Description

technical field [0001] The invention relates to a method for extracting danshensu from plant salvia miltiorrhiza, in particular to a method for extracting and purifying danshensu from an aqueous solution containing danshensu. Background technique [0002] Danshensu is one of the water-soluble components in the dry root of Salviamiltiorrhiza Bumge, a plant of the genus Salvia (Saivia) in the family Labiatae. It is an effective component for anti-myocardial ischemia and improving microcirculation. Efficacy. Zhang Decheng et al. (Research on Chinese Patent Medicine, Phase 1, 1982) reported its performance in detail. The structure of Danshensu is as follows: [0003] [0004] Danshensu is D(+)β-(3,4-dihydroxyphenyl) lactic acid, a kind of phenolic acid, easily soluble in water. Due to the active hydroxyl group in the molecule, oxidation and other reactions will occur when heated or exposed to light. Danshensu solution is very unstable, and it is easy to oxidize and turn red...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/47C07C59/52
Inventor 蔡建国邓修涂驭斌
Owner EAST CHINA UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com