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Process extracting purified danshen extract from red sage root

A technology of Danshensu and Danshen, applied in the separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problem of low production capacity

Inactive Publication Date: 2002-04-03
EAST CHINA UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a method for extracting and purifying Danshensu from the plant Salvia miltiorrhiza, to overcome the defect of low production capacity in the prior art, so as to facilitate large-scale purification of Danshensu

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1.5 kg of traditional Chinese medicine Salvia miltiorrhiza was extracted with 15 kg of water, and the extract was absorbed by an adsorption column filled with 200 ml of strong alkaline resin 717. The diameter of the adsorption column was 30 mm and the flow rate was 10 times the volume of resin per hour. After the extraction liquid is flowed, elution is carried out with 400 ml of 4% sodium hydroxide eluent at a rate of 2 times the resin volume per hour to obtain 420 ml of eluent. Adjust the pH of the eluent to 5 and add 850 ml. After extracting with ethyl acetate, the organic solvent containing Danshensu is vacuum concentrated to recover the solvent, and 13 grams of Danshensu product can be obtained, which contains 31% Danshensu.

Embodiment 2

[0022] After 5 kg of traditional Chinese medicine Salvia miltiorrhiza was extracted with 50 kg of water, the extracts flowed through an adsorption column filled with 2000 ml of HZ802 adsorption resin (80 mm in diameter) and an adsorption column filled with 400 ml of 717 ion exchange resin (30 mm in diameter). The flow rate is 4 liters per hour. After the extraction liquid is flowed, the HZ802 adsorbent is eluted with 3000 ml of 1% sodium hydroxide eluent at a rate of 2 times the resin volume per hour. The 717 resin was eluted with 800 ml of 10% sodium chloride at a rate of 2 times the resin volume per hour to obtain 850 ml of eluent. After adjusting the pH of the eluent to 3, 1800 ml of ethyl acetate was added for extraction. Then, the ethyl acetate solution containing Danshensu is concentrated and crystallized in vacuo to obtain 28 grams of Danshensu product, which contains 52% of Danshensu.

Embodiment 3

[0024] After 5 kg of traditional Chinese medicine Salvia miltiorrhiza was extracted with 50 kg of water, the extracts flowed through an adsorption column filled with 2000 ml of HZ802 adsorption resin (80 mm in diameter) and an adsorption column filled with 400 ml of D201×2 ion exchange resin (30 mm in diameter). ), the flow rate is 4 liters per hour. After the extraction liquid is flowed, the HZ802 adsorbent is eluted with 3000 ml of 1% sodium hydroxide eluent at a rate of 2 times the resin volume per hour. The D201×2 resin was eluted with 800 ml of 10% sodium chloride at a rate of 2 times the resin volume per hour to obtain 880 ml of eluent. After adjusting the pH of the eluent to 3, 2000 ml of ether was added for extraction. Then, the ether solution containing Danshensu is concentrated and crystallized in vacuum to obtain 12 grams of Danshensu product, which contains 91% of Danshensu.

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Abstract

A process for extracting purified danshen extract from red sage root includes adsorptive separation by polar resin or ion exchange resin, and extracting high-purity danshen extract from the eluant byorganic solvent.

Description

Technical field [0001] The present invention relates to a method for extracting danshensu from plant danshen, in particular to a method for extracting and purifying danshensu from an aqueous solution containing danshensu. Background technique [0002] Danshensu is one of the water-soluble components in the dried roots of Salvia miltiorrhiza Bumge, a plant of the Salvia miltiorrhiza Bumge in the Chinese medicine Labiatae. It is an effective component for preventing myocardial ischemia and improving microcirculation. Certain curative effect. Zhang Decheng et al. (Research on Chinese Patent Medicine, Phase 1 in 1982) reported on its performance in detail. The structure of Danshensu is as follows: [0003] Danshensu is D(+)β-(3,4-dihydroxyphenyl)lactic acid, which is a phenolic acid and is easily soluble in water. Due to the active hydroxyl group in the molecule, oxidation and other reactions will occur when heated or exposed to light. The Danshensu solution is very unstable and eas...

Claims

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Application Information

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IPC IPC(8): C07C51/47C07C59/52
Inventor 蔡建国邓修涂驭斌
Owner EAST CHINA UNIV OF SCI & TECH
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