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Histone containing compsn. to treat rheumatoid arthritis

A rheumatoid, histone technology, applied in drug combinations, peptide/protein components, anti-inflammatory agents, etc., can solve problems such as rheumatoid arthritis that does not suggest histone H1

Inactive Publication Date: 2000-06-07
SAMYANG GENEX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, the existing literature has not yet suggested the use of histone H1 as a drug for the treatment of rheumatoid arthritis

Method used

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  • Histone containing compsn. to treat rheumatoid arthritis
  • Histone containing compsn. to treat rheumatoid arthritis
  • Histone containing compsn. to treat rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] To estimate the mean value for each experimental group, the Student's t-test was used in the experiments of the present invention. Standard deviations were estimated using the Chi-square test. Results were considered statistically significant if p<0.05. Example 1: Induction of rheumatoid arthritis in experimental mice Induction of arthritis

[0035] 5-week-old DBA / 1J female mice were imported from Charles River Japan and acclimatized to animal rooms for 2 weeks before being used for experiments at 7 weeks of age (20-25 g).

[0036] Isolated and quantified chicken type II collagen (Sigma Chemical Co., St. Louis, MO, USA) was dissolved in 0.1 N acetic acid at a concentration of 2 mg / ml. This solution was mixed with an equal amount of complete Freund's adjuvant at 4°C to form a suspension. 100 microliters of this mixture were injected intravenously around the end of the tail vein, followed by further inoculations at 3 and 6 weeks after the first injection (D.E. Trentham...

Embodiment 2

[0043] Histone HI was obtained from Boehringer Mannheim (cat. no. 223549, lyophilizate from bovine thymus with electrophoretic homogeneity) and used in the experiments. Example 3: Preventive effect of histone H1 on arthritis Administration of histone H1

Embodiment 3

[0043] Histone HI was obtained from Boehringer Mannheim (cat. no. 223549, lyophilizate from bovine thymus with electrophoretic homogeneity) and used in the experiments. Example 3: Preventive effect of histone H1 on arthritis Administration of histone H1

[0044] As an experimental group for examining the preventive effect, from the 3rd week after the first injection (before induction of arthritis) to the 10th week, 1 mg / kg body weight of Histone H1. Histone HI was diluted to a concentration of 5 mg / ml in PBS. As a comparison group, from the 3rd week after the first injection (before induction of arthritis) to the 10th week, dexamethasone of 1 mg / kg body weight was administered to 10 mice by intraperitoneal injection twice a week— — Current anti-rheumatoid arthritis drugs. As a control group, 20 mice were administered 300 μl of PBS by intraperitoneal injection twice a week from the 3rd week to the 10th week after the first collagen injection. Arthritis Induction and Estimat...

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Abstract

The present invention relates to a novel use of histone and provides a pharmaceutical composition containing histone as an active ingredient to improve the symptoms of progressive, inflammatory and autoimmune arthritis. The pharmaceutical composition of the present invention includes histone, especially histone H1 as an active ingredient, and could include pharmacologically approved carriers if necessary. Histone H1 lowered induction of arthritis and reduced arthritis index more effectively than steroidal dexamethasone and also had a significant preventive effect.

Description

technical field [0001] The present invention relates to the application of histone H1 in improving the inflammatory symptoms of arthritis. Histone H1 reduces the induction of arthritis, and compared with conventional drugs, it can reduce the index of arthritis more effectively, and has a significant preventive effect. Background of the invention [0002] The present invention relates to physiologically active compounds and compositions comprising the compounds for improving the symptoms of progressive, inflammatory and autoimmune arthritis. Although many anti-arthritic drugs have been developed, arthritis is still a serious disease worldwide due to the increase of aging population. Although death from arthritis is very low, quality of life for patients with the disease is compromised by poor mobility. [0003] Of the many types of arthritis, the most notable one is rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease induced by the action of autoreactive T ...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61K38/16A61K38/17A61P19/02A61P29/00
CPCA61K38/1709A61P19/02A61P29/00A61K38/00
Inventor 裴仁洙金东洙任惠准郑年哲李龙源洪承绪李贤秀
Owner SAMYANG GENEX
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