Ginkgo leaf extraction injection for treating ischemic cerebral apoplexia and its preparation method

An ischemic cerebral apoplexy, ginkgo biloba technology, applied in the directions of medical raw materials derived from Ginkgo biloba, cardiovascular system diseases, drug combinations, etc. treatment, etc.

Inactive Publication Date: 2006-05-17
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Western medicine often emphasizes treatment and neglects rehabilitation, ignoring the treatment of the patient's function during the recovery period. From the perspective of Western medicine, there is currently no active and effective treatment method for the recovery period.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 100g of Ginkgo biloba leaves, add 1200ml of 60% ethanol, reflux and extract 3 times, each time for 2 hours, filter, combine the extracts, recover the ethanol under reduced pressure, concentrate to a relative density of 1.05 (60°C), and let stand for 28 hours , remove the insoluble matter in the upper layer, extract 4 times with 6 times the amount of ethyl acetate, combine the extracts, recover the ethyl acetate, let it stand for 48 hours, take the supernatant, concentrate to a relative density of 1.19 (60 ° C), and vacuum dry ( 60°C), pulverized, and put the dry powder in a supercritical extractor, at an extraction pressure of 3.5×10 4 Under the condition of Kpa ​​and extraction temperature of 45°C, liquid carbon dioxide is used as fluid extraction, quality inspection, and semi-finished products are obtained. Take the semi-finished product and add 800ml of water for injection, let it stand, filter, add 2g of sodium bisulfite, 6.9g of sodium chloride to the filtrat...

Embodiment 2

[0015] Weigh 100g of ginkgo leaves, add 1000ml of 70% ethanol, reflux extraction twice, each time for 1 hour, filter, combine the extracts, recover the ethanol under reduced pressure, concentrate to a relative density of 1.08 (60°C), and let stand for 30 hours , remove the insoluble matter in the upper layer, extract 5 times with 5 times the amount of ethyl acetate, combine the extracts, recover the ethyl acetate, let it stand for 28 hours, take the supernatant, concentrate to a relative density of 1.22 (60 ° C), and vacuum dry ( 60°C), pulverized, and put the dry powder in a supercritical extractor, at an extraction pressure of 3.5×10 4 Under the condition of Kpa ​​and extraction temperature of 45°C, liquid carbon dioxide is used as fluid extraction, quality inspection, and semi-finished products are obtained. Take the semi-finished product and add 900ml of water for injection, let it stand, filter, add 2.1g of sodium bisulfite, 6.78g of sodium chloride to the filtrate, and a...

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PUM

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Abstract

The invention discloses a preparation method of ginkgo leaf injection for treating ischemic cerebral apoplexy: taking ginkgo leaves, adding ethanol to reflux extraction, filtering, combining the extracts, recovering ethanol under reduced pressure, concentrating, standing still, and removing the upper layer The insoluble matter is extracted with ethyl acetate, the extracts are combined, the ethyl acetate is recovered, left to stand, the supernatant is taken, concentrated, vacuum-dried, crushed, and the dry powder is extracted in a supercritical extractor to obtain a semi-finished product; the semi-finished product is added to Water for injection, stand still, filter, add sodium bisulfite, sodium chloride to the filtrate, and add water for injection, adjust pH, filter, fill, press cap, sterilize, and obtain. The medicine prepared by the present invention has the effects of promoting blood circulation and removing blood stasis, dredging meridians and activating collaterals, and is used for the treatment of ischemic cerebral apoplexy with Qi-deficiency and blood-stasis syndrome in the meridian of dialectical genus of traditional Chinese medicine. Unique curative effect.

Description

technical field [0001] The invention relates to a preparation method of a medicine for treating ischemic cerebral apoplexy. Background technique [0002] Stroke is one of the most common diseases among middle-aged and elderly people, and it has the characteristics of high incidence rate, high mortality rate and high disability rate. Statistics in my country in recent years have shown that stroke ranks second in the cause of death, second only to malignant tumors. According to domestic epidemiological survey results, the incidence rate of stroke in my country is 120-180 / 100,000 people, and the number of patients is about 5-6 million people. About 1 million people die from cerebral apoplexy every year, about 3 / 4 of the survivors lose their ability to work in varying degrees, and more than 40% of them are severely disabled. About 1.3 to 1.5 million new cases occur each year, of which more than 600,000 cases are cerebral apoplexy. infarction patients. Therefore, how to improv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61P9/10A61K127/00
Inventor 张晴龙
Owner 张晴龙
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