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Pharmaceutical use of asiaticoside

A technology of asiaticoside and medicine, which is applied in the application field of asiaticoside in the preparation of medicine, and can solve the problems that the use of the medicine has not been reported.

Inactive Publication Date: 2006-07-19
上海海天医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicinal use of asiaticoside has not been reported so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Experiments were performed with healthy adult SD rats. The SD rats were divided into: normal control group, asiaticoside treatment 1, 2, 3 and 4 groups, and liver fibrosis model group. in:

[0010] 1) In the normal control group, 10 SD rats were taken for intraperitoneal injection of saline and intragastric administration of distilled water;

[0011] 2) In the liver fibrosis model group, 10 SD rats were taken and injected intraperitoneally with 0.5% dimethylnitrosamine solution made of normal saline for 12 times, with a dose of 10 mg dimethylnitrosamine Amine / kg body weight / time (2ml of 0.5% dimethylnitrosamine / kg body weight / time), the injection time is the first cycle, and the frequency of injection once a day is continuously injected for 3 days, a total of 3 injections; 2- Injection once a week for 4 weeks, 3 times in total; 2 consecutive days a week, 1 injection per day in weeks 5-7, 6 times in total. A total of 12 injections of 0.5% dimethylnitrosamine solution ...

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PUM

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Abstract

The present invention discloses the use of asiaticoside in preparing medicine for treating liver fibrillation. Asiaticoside can suppress the growth and proliferation of fibroblast obviously, so that it may be used in treating liver fibrillation and further in preventing hepatocirrhosis.

Description

technical field [0001] The invention relates to the medicine use of asiaticoside, in particular to its use in preparing medicines for preventing hepatic fibrosis. Background technique [0002] Madecassoside is a known substance, which is a representative component of total asiaticosides (an effective pharmaceutical ingredient extracted from Centella asiatica, mainly containing triterpenoid saponins), It belongs to pentacyclic triterpenoids. The molecular formula of asiaticoside is C 48 h 78 o 19 , the substance is a fine needle-like crystal slightly soluble in water, methanol, and ethanol. The known medicinal use of asiaticosides is to use it to prepare medicines for treating scleroderma and treating trauma, surgical wounds and burns. The medicinal use of asiaticoside has not been reported so far. [0003] The applicant has found through long-term and in-depth research that asiaticoside contained in total asiaticoside has the effect of inhibiting the growth and prolife...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P1/16
Inventor 蒋毅董大伦
Owner 上海海天医药科技开发有限公司