Application of coniferyl ferulate in preparing anticancer medicine

Abstract

The invention relates to the research and development of anticancer active ingredients in Rhizoma Chuanxiong, in particular to the application of coniferyl ferulate in anticancer drugs. The advantages of the present invention are as follows: for the first time, the present invention separates and purifies coniferyl ferulate from the traditional Chinese medicine——Chuanxiong Rhizoma Chuanxiong, and provides a new lead compound for the design of new drugs based on the active ingredients of traditional Chinese medicine; The purification method is simple and easy to operate, has good repeatability and mild conditions, and is very suitable for the preparation of active ingredients of traditional Chinese medicines with poor chemical stability; it lays a foundation for the development and industrialization of new anticancer drugs based on traditional Chinese medicines.

Description

technical field [0001] The invention relates to the research and development of anticancer active ingredients in Rhizoma Chuanxiong, in particular to the application of coniferyl ferulate in the preparation of anticancer drugs. Background technique [0002] Since Chinese medicine is a precious heritage of the motherland's medical science, it has been clinically practiced for thousands of years, and has formed a systematic theoretical system of traditional Chinese medicine, which has an extremely extensive application base in our country. The development of new drugs based on traditional Chinese medicine has favorable factors such as clear goals, less toxic and side effects, and many sources of raw materials. [0003] Rhizoma Chuanxiong is the dried rhizome of Ligusticum chuanxiongHort., an Umbelliferae plant. It is reported that it contains various active ingredients such as lactones, alkaloids, organic acids or phenols, and neutral oils. The main pharmacological effects o...

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Problems solved by technology

[0004] So far, only Ligustrazine has been reported that the active ingredients of Chuanxiong can inhibit tumor cells [Document 5. Zhang Chunling, Xiao Wei, Wang Yingnian. Chinese Practical Medicine. Regulatory effect of positive PMBC secretion of IL-4 and IL-6; Literature 6. Lin Hongsheng, Li Shuqi, Pei Yingxia, etc. Chinese Journal of New Drugs. 8(6), 384-386, 1999 Ligustrazine and matrine on cancer cells and endothelial cells Adhesion and the influence of adhesion factor expression; Literature 7. Lin Hongsheng, Li Shuqi, Park Bingkui, etc. China Tumor. 8(12), 574-576, 1999 The effect of Sanshen Granule on endothelial cells and adhesion factors in lung cancer metastasis; Literature 8. Cui Wei, Xu Shijie, Teng Jingru, etc. Chinese Journal of Basic Medicine of Traditional Chinese Medicine. 3(1), 27-28, 31, 1997 Chinese medicine for promoting blood circulation and removing blood stasis inhibits tumor cells—experimental research on platelet aggregation], but ligustrazine in Ligusticum chuanxiong The content of Ligustrazine is extremely low, and Ligustrazine is easy to sublimate simultaneously, so extracting Ligustrazine from Ligusticum Ligusticum for anti-tumor research has not been reported.

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