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Oral drop pills for treating coronary disease and preparation method thereof

A technique for coronary heart disease and dropping pills, which is applied in the field of pharmaceutical compositions, can solve the problems of low dissolution rate, unfavorable improvement of patients' ability to seek medical treatment, and increased cost of medication, so as to achieve accelerated dissolution and absorption, improved bioavailability, and increased total surface area. big effect

Inactive Publication Date: 2007-01-31
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
[0015] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0040] The preparation method of refined Guanxin dripping pills of the present invention will be further described with several groups of specific examples.

[0041] Group 1: Tests with a single matrix

[0042] 1. Weigh a certain amount of traditional Chinese medicine raw materials according to the ratio given in [Preparation Method] 1, and then follow the section [Appendix: A Preparation Method of Chinese Medicine Extract] to first prepare a Chinese herbal medicine containing Radix Paeoniae Rubra, Chuanxiong, Safflower, Salvia, Radix Extract dry powder and volatile oil of five flavors of pure traditional Chinese medicine active ingredients such as incense for standby;

[0043] 2. Substrate: polyethylene glycol (2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0044] 3. Proportion—in g or kg, in pa...

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PUM

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Abstract

The invention relates to a medicinal oral preparation with the functions of activating blood circulation, removing stasis and treating coronary disease and angina pectoris, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, higher medicinal content, smaller amount of administration, accurate administration dosage, easy administering, low price, and facilitated carrying. The medicine is prepared through the conventional drop pill preparing process.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has the effect of promoting blood circulation and removing blood stasis, and is used for treating coronary heart disease and angina pectoris, especially relates to a kind of medicine composition oral dripping pill that is based on the refined Guanxin Tablet of traditional Chinese medicine prescription and is reformed by dosage form preparation. Background technique [0002] According to the ministerial drug standard WS 3 - Refined Guanxin Tablets prepared according to the formula and extraction process given in B-1269-92, is an oral Chinese medicine preparation that has the effect of promoting blood circulation and removing blood stasis, and is used for the treatment of coronary heart disease and angina pectoris. It has been clinically verified and has stable quality , with definite curative effect, is a commonly used pharmaceutical preparation for clinical and family treatment of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/71A61K36/236A61K36/286A61K36/53A61K36/48A61P9/10
Inventor 曲韵智
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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