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Chicken gallbladder extractum dripping pills and its preparation method

A chicken gallbladder and extract technology, applied in the field of medicine, can solve the problems of affecting appearance and use compliance, difficult to control quality, complicated preparation process, etc., and achieve the effects of being beneficial to cleaning and labor protection, low production cost, and simple equipment.

Inactive Publication Date: 2007-01-31
张德桐
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But also find its deficiency in its preparation and clinical use: one oral dose is big (10ml-20ml) or more, mouthfeel is not good, especially its corrective agent is honey and sucrose, sticky and uncomfortable, the bitter taste of bile stays in Oral cavity, if not used for a long time, patients, especially diabetic patients and children are difficult to accept; the preparation process is complicated, the stability is not good, the quality is difficult to control, and there will be precipitation after long-term storage. Although it does not affect the curative effect, it will affect the appearance and compliance of use; liquid Glass bottle packaging, inconvenient to transport, inconvenient to carry, inconvenient to take, poor compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] [embodiment one] prepare chicken bile extract drop pill 1000g

[0017] Get chicken bile extract in terms of chenodeoxycholic acid 11g, polyethylene glycol 6000 920g, mannitol 30g.

[0018] Preparation

[0019] (1) 920 g of polyethylene glycol 6000 and 30 g of mannitol are placed in a water bath, heated in a water bath until completely melted, and 11 g of chicken bile extract is added in terms of chenodeoxycholic acid, and then quickly transferred to an insulated liquid storage tank, 80-90 ℃ airtight heat preservation.

[0020] (2) Use a quantitative constant control dropping pill machine to drop from top to bottom, the coolant is liquid paraffin, and the dropping speed is 30 pills / min, drain the formed drop pills, wipe off the cooling liquid, and pour it into an absorbent paper tray After being fully dried, it is sent for inspection, packaged and ready to be obtained.

Embodiment 2

[0021] [embodiment two] prepare chicken bile extract drop pill 1000g

[0022] Get chicken bile extract as chenodeoxycholic acid 22g, polyethylene glycol 6000 850g, mannitol 30g

[0023] The preparation method is the same as in Example 1.

Embodiment 3

[0024] [embodiment three] prepare chicken bile extract drop pill 1000g

[0025] Get chicken bile extract in terms of chenodeoxycholic acid 33g, polyethylene glycol 6000 800g. Mannitol 15g.

[0026] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention provides a chicken gallbladder extractum dripping pills and its preparation method, wherein the dripping pill comprises (by weight ratio) chenodeoxycholic acid 11-110, ground substance 550-950. The preparing method comprises heating the ground substance to melting phase, charging in chicken gallbladder extractum, mixing uniformly airtight thermal insulation at 80-90 deg. C, preparing the dripping pills with quantitative constant control droplet machine, cooling with fluid wax, removing cooling liquid, drying, checking and packaging.

Description

[technical field] [0001] The invention relates to the field of medicine, in particular to a new dosage form of chicken bile extract and a preparation method thereof. [Background technique] [0002] The medicinal use of chicken gall to treat whooping cough has existed in ancient times. Modern medical research has confirmed that the main component of chicken bile is chenodeoxycholic acid (CDCA), followed by cholic acid (CA), wherein chenodeoxycholic acid accounts for 80% of the total cholic acid. Chenodeoxycholic acid has strong anti-inflammatory, cough-relieving, expectorant, and anti-asthma activities, and its anti-cough, anti-asthma, and anti-inflammatory activities rank first among all animal bile. Gu Xueqiu editor-in-chief's 1981 edition of pharmaceutical preparation notes mentioned that in terms of the effect of treating pertussis and chronic bronchitis, compared with cattle, sheep, pigs, and chicken bile, chicken bile is the best. After removing the roughness and extr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/413A61K9/20A61P11/14
Inventor 张德桐张茁牟艳芳
Owner 张德桐
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