Method and apparatus for patch-clamp measurements on cells

Abstract

The invention shows a method for patch-clamp experiments on cells or similar structures, where at least one cell is inserted into the lumen of a capillary and is positioned inside the capillary so, that a sufficiently tight seal with a resistance exceeding 1, preferably 10 GigaOhm develops between cell membrane and inner surface of the capillary. Along its length said capillary has at least at one position a smaller inner diameter than the outer diameter of said cell. Preferably the cell is inserted and positioned in the capillary by pressure, suction, sedimentation or centrifugation of a suspension or solution containing said cell. An apparatus for performing experiments using this method is described.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

Login to View More

AI Technical Summary

Benefits of technology

This patented technology allows researchers to measure electrical currents by inserting an electrode inside their tiny parts called lamina neapritis that helps them study biological processes like nerve transmission. By modifying certain areas within this area, they may have better understanding about how these changes occur compared to traditional methods used to detect conductive materials. Additionally, there're some advantages over existing techniques: 1) It provides more accurate measurements than previous methods; 2) No tools were necessary during measurement process due to its non-invasiveness and durability against damage caused by external forces while still being effective at removing unwanted samples. Overall, this new technique simplifies the way scientists work through experiments involving studying specific aspects of organisms.

Problems solved by technology

Technological Problem addressed in this patented technical problem is how to create a reliable and efficient way to test various biomedical applications involving tiny particles called microelekmaels.

Images