Tablets quickly disintegrated in the oral cavity

A tablet and preparation technology, applied in the field of rapidly disintegrating tablets, can solve problems such as difficult handling, unsatisfactory drug stability, complex manufacturing process and production equipment

Inactive Publication Date: 2002-03-13
SUMITOMO DAINIPPON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned techniques are still not satisfactory in ensuring the stability of the dosage form, because a relatively large amount of water must be used; or in ensuring that the product is strong enough to counteract losses during dispensing
In addition, some products are di...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Tandospirone citrate 5mg

[0033] D-Mannitol 103mg

[0034] Corn starch 11mg

[0035] Magnesium Stearate 1mg

[0036] The above ingredients were mixed and tableted with a hydraulic press (manufactured by Riken) at a pressure of 50 kgf to form tablets with a diameter of 7 mm and a weight of 120 mg.

Embodiment 2

[0038] Tandospirone citrate 5mg

[0039] D-Mannitol 90mg

[0040] Corn starch 24mg

[0041] Magnesium Stearate 1mg

[0042] The above ingredients were mixed and tableted with a hydraulic press (manufactured by Riken) at a pressure of 50 kgf to form tablets with a diameter of 7 mm and a weight of 120 mg. Example 3

Embodiment 3

[0043] Tandospirone citrate 10mg

[0044] Lactose 150mg

[0045] Wheat Starch 37mg

[0046] Sodium stearyl fumarate 3mg

[0047] The above ingredients were mixed and tableted with a hydraulic press (manufactured by Riken) at a pressure of 50 kgf to form tablets with a diameter of 8 mm and a weight of 200 mg.

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Abstract

There is provided a tablet preparation showing quick disintegratability in the mouth and good sensory acceptability and yet having an adequate strength to resist damage in the course of distribution. Each tablet comprises a starch, a water-soluble excipient and a medicament and does not substantially contain a binder other than starch.

Description

technical field [0001] The present invention relates to a rapidly disintegrating tablet which exhibits the ability to rapidly disintegrate or dissolve in the mouth with little or no water. Background technique [0002] Many oral drug forms are known so far, but little attention has been paid to the ease of patient administration, and there is a need for a drug form suitable for the elderly, children and seriously ill patients, who are generally not very cooperative. For example, tablets and capsules are the most commonly used drug forms in terms of drug accuracy, physicochemical stability, and manufacturing cost, but not few patients dislike this drug form because of its unsuitable taste and Easy to get stuck in throat. Powders and granules may be incompletely swallowed, leaving a residue in the mouth and a long unpleasant aftertaste. Liquid medication forms such as syrups are considered suitable for the elderly and children, but dispensing doses fr...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/20
CPCA61K9/2059A61K9/0056A61K47/36
Inventor 西井宏行小林浩久音田和也
Owner SUMITOMO DAINIPPON PHARMA CO LTD
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