Tablets quickly disintegrated in the oral cavity

Abstract

There is provided a tablet preparation showing quick disintegratability in the mouth and good sensory acceptability and yet having an adequate strength to resist damage in the course of distribution. Each tablet comprises a starch, a water-soluble excipient and a medicament and does not substantially contain a binder other than starch.

Description

technical field [0001] The present invention relates to a rapidly disintegrating tablet which exhibits the ability to rapidly disintegrate or dissolve in the mouth with little or no water. Background technique [0002] Many oral drug forms are known so far, but little attention has been paid to the ease of patient administration, and there is a need for a drug form suitable for the elderly, children and seriously ill patients, who are generally not very cooperative. For example, tablets and capsules are the most commonly used drug forms in terms of drug accuracy, physicochemical stability, and manufacturing cost, but not few patients dislike this drug form because of its unsuitable taste and Easy to get stuck in throat. Powders and granules may be incompletely swallowed, leaving a residue in the mouth and a long unpleasant aftertaste. Liquid medication forms such as syrups are considered suitable for the elderly and children, but dispensing doses fr...

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned techniques are still not satisfactory in ensuring the stability of the dosage form, because a relatively large amount of water must be used; or in ensuring that the product is strong enough to counteract losses during dispensing

In addition, some products are difficult to handle, while others require complex manufacturing processes or special production equipment

For example, techniques suitable for more versatile development are disclosed in JP Kokai H10-182436 and JP Kokai H9-71523, but there is still room for improvement in rapid disintegration in the mouth