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Prepn of high-selectivity heavy metal lead repellent

A high-selectivity, heavy-metal technology, applied in the direction of anti-toxic agents, active ingredients of artificially synthesized polymer materials, drug combinations, etc., can solve the problems of poor selectivity and low curative effect

Inactive Publication Date: 2003-01-01
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, looking at the current drugs for the prevention and treatment of heavy metal poisoning, most of them have defects such as poor selectivity and low curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: get 2g powdery chitosan, add 60ml 0.2mol / l CuCl 2 In the solution, after stirring at room temperature for 5 hours, adjust the pH to 6 with dilute sodium hydrochloride solution, filter and wash with methanol, place in a system with a weight ratio of methanol and water of 8:2, and add 0.5ml of formaldehyde , after reacting at room temperature for 5 hours, filter and wash, then place in a system with a weight ratio of ethanol and formic acid of 8:2, stir at room temperature for 24 hours, filter, wash, and dry to obtain a selective removal agent for heavy metal lead .

Embodiment 2

[0020] Embodiment 2: get 5g powdery chitosan, add in the lead nitrate solution of 30ml 0.1mol / l, after stirring at room temperature for 8 hours, adjust pH=6 with dilute sodium hydroxide solution, filter, place ethanol after washing Add 1.5ml of glutaraldehyde to a system with a weight ratio of 7:3 to water, react at room temperature for 6 hours, filter, wash, then place in a system with a weight ratio of ethanol to acetic acid of 7:3, and stir at room temperature for 24 hours , Filter, wash, and dry to obtain a high-selection heavy metal lead remover.

[0021] Attached Table Adsorption results of chitosan and "template" chitosan on metal ions

[0022] (mg / g)

[0023] Sample Iron Copper Zinc Lead Mercury

[0024] Chitosan 138 158 130 152 232

[0025] "Template" chitosan 41 44 26 158 266

[0026] sugar

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Abstract

The present invention relates to the preparation of medicine for preventing and treating lead poisoning. Technological, the present invention features that natural polymer chitosan and metal ion formcompound, the compound is crosslinked and metal ion eliminated to form "template", and the "template" is used to adsorb harmful heavy metal ions selectively while absorbing no beneficial metal ion. The present invention is superior to available heavy metal ion repellent in that it has selectivity to heavy metal ions.

Description

technical field [0001] The invention relates to a preparation method of a drug for preventing and treating heavy metal lead poisoning, in particular, the invention relates to a preparation method of a highly selective heavy metal lead removal agent. Background technique [0002] The prevention and treatment of human heavy metal poisoning is a major issue related to the health of employees in related industries in our country. People have carried out a lot of work from different aspects and made great progress. For example, some new drugs or preventive methods have been applied clinically. However, looking at the current drugs for the prevention and treatment of heavy metal poisoning, most of them have defects such as poor selectivity and low efficacy. Therefore, technological innovation in this area is still an important topic at present. [0003] Chitosan is the product of deacetylation of natural polymer chitin. In recent years, a large number of studies have shown that i...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K31/80A61P39/02
Inventor 王爱勤孙胜玲
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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