Soft bilobalide capsule and its prepn.
The technology of ginkgolide and soft capsule is applied in the field of ginkgolide pharmaceutical preparation, and achieves the effects of good stability, simple preparation method and convenient taking.
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Embodiment 1
[0017] Composition of medicinal liquid materials: ginkgolide 100g, soybean oil 450g, beeswax 10g;
[0018] Capsule shell material composition: gelatin 100g, glycerin 43g, water 102g, paraffin methyl ester 0.18g, parasol
[0019] Ethyl ester 0.1g.
[0020] Preparation method: take beeswax and put it in soybean oil, heat it until it melts, let it cool to room temperature, add ginkgolide, stir it with a colloid mill, and get the medicine liquid; take gelatin, glycerin, water, put it in a suitable container and heat it to 80 Dissolve at ℃, filter, add the filtrate to the paradigin methyl ester and paraben ethyl ester, mix well, and keep warm at 60°C to obtain the rubber solution; take the above-mentioned medicinal liquid and rubber solution, press them with soft capsule production equipment, and after drying Promptly get the ginkgolide soft capsule of the present invention.
Embodiment 2
[0022] Composition of liquid medicine materials: ginkgolide 40g, soybean oil 200g, beeswax 6g;
[0023] Capsule shell material composition: 50g gelatin, 20g glycerin, 51g water, 0.1g paradoxine methyl ester, paradoxine B
[0024] Esters 0.08g.
[0025] Preparation method: take beeswax and put it in soybean oil, heat it until it melts, let it cool to room temperature, add ginkgolide, stir it with a colloid mill, and get the medicine liquid; take gelatin, glycerin, water, put it in a suitable container and heat it to 80 Dissolve at ℃, filter, add paralyzed methyl ester and paralyzed ethyl ester to the filtrate, mix well, and keep warm at 60°C to obtain a rubber solution; take the above-mentioned medicinal liquid and rubber solution, press them with soft capsule production equipment, dry, Ready to serve. Pharmacodynamic study of ginkgolide soft capsules on ischemic stroke 1. Effect of ginkgolide soft capsules (hereinafter referred to as GTL) on cerebral ischemia 1...
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