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Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of granule of formula of Chinese traditional medicine

A technology of traditional Chinese medicine formula granules and infrared spectroscopy, which is applied in the field of traditional Chinese medicine detection, can solve problems such as inability to strictly control, loss of system originality and compatibility, and difficulty in identification, so as to accelerate the process of quality control of traditional Chinese medicine, accelerate the modernization and internationalization of traditional Chinese medicine Speed, intuitive identification of the effect

Inactive Publication Date: 2003-10-08
TSINGHUA UNIV
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Problems solved by technology

However, these methods lose the overall analysis, lose the originality and compatibility of the system
Although gas chromatography and liquid chromatography have very strong separation capabilities, due to the differences in the growth and other conditions of the medicinal materials themselves, that is, the traditional Chinese medicinal medicinal materials are often not strictly controlled from the source, which will cause the "active ingredients" or "control ingredients" to be separated. Instability or insufficient reliability, coupled with the fact that standard compounds are not easy to obtain during analysis, making it difficult to achieve identification

Method used

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  • Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of granule of formula of Chinese traditional medicine
  • Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of granule of formula of Chinese traditional medicine
  • Multistage macroscopical fingerprint method for identifying non-separated extracted infrared spectrum of granule of formula of Chinese traditional medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Identification and identification of Houttuynia cordata and gardenia and their corresponding formula granules

[0049] (1) The experiment uses a Spectrum GX FTIR spectrometer (Perkin Elmer, USA), a DTGS detector, and a resolution of 4cm -1 , measuring range 4000~400cm -1 , and 32 scans were accumulated to obtain spectra. A Portable Controller Programmable Temperature Control Unit Model 50-886 (Love Control Corporation) was used.

[0050] (2) Houttuynia cordata, Gardenia jasminoides and their respective formulation granule samples were ground separately, added with KBr, pressed into tablets to make samples, placed in the temperature-changing pool of the instrument, the temperature was programmed from room temperature to 150°C, and real-time interval sampling was carried out in situ. Every time the temperature rises by 10°C, the infrared spectrum is collected, and a series of spectra-variable temperature dynamic spectra are obtained continuously.

[0051] (3...

Embodiment 2

[0069] Example 2: Identification of Zicao Formula Granules

[0070] (1) The experiment uses a Spectrum GX FTIR spectrometer (Perkin Elmer, USA), a DTGS detector, and a resolution of 4cm -1 , measuring range 4000~400cm -1 , scan 32 and accumulate spectrum. A Portable Controller Programmable Temperature Control Unit Model 50-886 (Love Control Corporation) was used.

[0071] (2) Comfrey formula granule samples were ground separately, added with KBr, pressed into tablets, made into samples, placed in the temperature-changing pool of the instrument, and the temperature was programmed from room temperature to 150°C. In situ real-time interval sampling, every 10°C temperature rise, collected infrared spectra , continuously acquire a series of spectra—variable temperature dynamic spectra.

[0072] (3) For the infrared spectrogram at room temperature (~20° C.), derivation processing of the spectrogram is performed to obtain a derivative spectrum.

[0073] (4) For the series of temp...

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Abstract

This invention relates to a method for verifying Chinese medicine formulation particle unseparatedly extract multilevel macro-finger mark with infrared spectrum in the following steps: adding potassium bromide into the said powder for making tablet sample to determine its middle infrared spectrum, diffuse reflection near-infrared, middle infrared spectrums, reflection spectrum and attenuation total reflection spectrum to get and draw second-order derivative spectrum diagram, to determine two-dimensional related infrared spectrum, to compare related diagram spectrums in lever and determine relative content of main secondary materials in particles.

Description

technical field [0001] The present invention relates to an infrared spectrum non-separation extraction multi-level macro fingerprint analysis and identification method of a mixture with extremely complex components, in particular to an infrared spectrum non-separation extraction multi-level macro fingerprint identification method of traditional Chinese medicine formula granules, which belongs to the detection technology of traditional Chinese medicine field. Background technique [0002] The quality control of traditional Chinese medicine is the basis and key to promote traditional Chinese medicine and Chinese medicine. In October 2000, the State Drug Administration of China issued the "Technical Requirements for Fingerprint Research of Traditional Chinese Medicine Injections (Provisional)" to guide and standardize the research on fingerprints of traditional Chinese medicine. The European Community was the first to stipulate fingerprints as quality standards in the form of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/35G01N21/3563G01N21/359G01N33/15
Inventor 孙素琴周群秦竹陶家洵
Owner TSINGHUA UNIV
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