Radioprotective agents

A pre-radiation, ionizing radiation technology, applied in genistein, prevention or treatment of acute or chronic damage caused by exposure to radiation, human beings from the toxic effects of radiation, radiation protection agent field, can solve problems such as toxic effects

Inactive Publication Date: 2003-10-08
阿拉·夏皮罗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology prevents harmful cellular damage when treating tumors after being exposed to high doses of X rays (Xray). It suggests injecting certain substances into specific areas where they are likely causing injury if used at too much concentration. By giving this type of material to people who have been given it, we aim to help them avoid having healthy tissues like those surrounding us affected while still getting ridged off deadly diseases such as leukemia.

Problems solved by technology

Technologies aimed towards developing new types of medicinal agents called pharmaceuticals (pharmacologists) capable of effectively treating diseases associated with high levels of radiation injury while minimising harmful side effects. Current methods involve giving them alone or combining different chemical entities into one molecule. While there exist various ways to deliver these chemoagents safely and efficiently to target areas where healthy tissue needs to remain unhealthily undergoing radiation therapysmography, none currently available options offer all three important benefits: 1) reduced risk of radiation induced injuries; 2) reduction of unwanted secondary reactions mediators released when exposed to radiation; 3) enhancement of specific immune responses against disease causing inflammative stress and potentially benefiting both normal and abnormal tissues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The radioprotective capacity of CD2F1 male mice exhibited by isoflavones, particularly genistein, was determined by exposure to a lethal dose of cobalt-60 radiation (9.5 Gy, 0.6 Gy / min) for thirty days. Before radiation, the control group received saline and polyethylene glycol 400 (vehicle for genistein). 400 mg / kg single dose or multiple doses of 100 mg / kg / time genistein (Sigma Chemical Co. , St. Louis, MO).

[0056]44% of mice survived if they received genistein only before radiation; 0% if they were given genistein only after radiation; 69% if they received genistein both before and after radiation . This was compared to 0% survival in the control group receiving saline and 19% survival in the genistein vehicle, polyethylene glycol 400. For mice given multiple low doses of genistein (100 mg / kg) orally, the survival rate was 0% if genistein was given four days before radiation; the survival rate was 0% if given after radiation; four days before radiation and 100 ...

Embodiment 2

[0058] In a subsequent study, using the method of Example 1 and mice, a single dose of 100 or 400 mg / kg genistein was administered subcutaneously 24 hours before 9.5 Gy irradiation. Mice showed 30-day survival rates of 69% and 81%, respectively. These experiments showed that subcutaneous injections of genistein protected mice from lethal doses of ionizing radiation.

Embodiment 3

[0060] According to the method of embodiment 1 and 2, use comprises genistein, genistein, daidzein, daidzein, glycitin, glycinin, chickwein A, formononetin, O - desmethyl pterostilbene, equol, etc., their glycosides and derivatives and their mixtures. A similar radiation protection effect can be shown.

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Abstract

A non-toxic and effective isoflavone radioprotective agent for treating or preventing effects and damage due to radiation exposure, or increasing the survivability to a lethal dose of radiation. The isoflavone can be administered orally, subcutaenously, intramuscularly, intravenously, transdermally, intranasally, or rectally. The isoflavone is administered chronically, and/or before, during and/or after radiation exposure. These radioprotective agents can be used to protect personnel exposed to radioactive substances.

Description

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Claims

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Application Information

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Owner 阿拉·夏皮罗
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