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Compound preparation fortreating psoriasis vulgaris and its preparation process

A technology of psoriasis vulgaris and compound preparations, which is applied to medical preparations containing active ingredients, skin diseases, pharmaceutical formulas, etc., can solve serious problems, insufficient curative effect, skin irritation and other problems, achieve complementary curative effects, improve Pros and cons ratio, effect of reducing adverse reactions

Inactive Publication Date: 2004-08-04
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein all-trans retinoic acid (RA) topical treatment of psoriasis has a certain therapeutic effect, but the curative effect is not sufficient when used alone, and with the increase of RA concentration, the skin irritation is more serious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: prepare the compound preparation ointment for the treatment of psoriasis vulgaris

[0035] (1) Weigh the following components by weight (g):

[0036] Clobetasol Propionate 10

[0037] All-trans retinoic acid 5

[0038] Polysorbate 80 600

[0039] Sorbitan stearate 60 2000

[0040] Propyl gallate 40

[0041] 2,6-di-tert-butyl-p-cresol 40

[0042] Vitamin E 100

[0043] Citric acid 2

[0044] Propylene Glycol 3000

[0045] Absolute ethanol 1200

[0046] Lanolin 2400

[0047] Yellow Vaseline Increased to 20000

[0048] (2) Yellow petrolatum and lanolin were pretreated at 100°C for 1 hour, then the lanolin, polysorbate 80, sorbitan stearate 60 and yellow petrolatum were mixed and heated to 70°C to melt, stirred well and set aside;

[0049] (3) dissolve citric acid with propylene glycol, then dissolve propyl gallate, then add in (2) and stir and emulsify;

[0050] (4) Dissolve vitamin E and 2,6-di-tert-butyl-p-cresol with 1000g of absolute ethanol, ...

Embodiment 2

[0053] Embodiment 2: prepare the compound preparation ointment for the treatment of psoriasis vulgaris

[0054] (1) Weigh the following components by weight (g):

[0055] Clobetasol Propionate 4

[0056] All-trans retinoic acid 20

[0057] Polysorbate 80 300

[0058] Sorbitan Stearate 60 2500

[0059] Propyl gallate 20

[0060] 2,6-di-tert-butyl-p-cresol 60

[0061] Vitamin E 150

[0062] Citric acid 3

[0063] Propylene Glycol 4000

[0064] Absolute ethanol 1600

[0065] Lanolin 3000

[0066] Yellow Vaseline Increased to 20000

[0067] (2) Yellow petrolatum and lanolin were pretreated at 80°C for 1 hour, then the lanolin, polysorbate 80, sorbitan stearate 60 and yellow petrolatum were mixed and heated to 80°C to melt, and stirred well for later use;

[0068] (3) dissolve citric acid with propylene glycol, then dissolve propyl gallate, then add in (2) and stir and emulsify;

[0069] (4) Dissolve vitamin E and 2,6-di-tert-butyl-p-cresol with 1200g of absolute ethanol,...

Embodiment 3

[0072] Embodiment 3: prepare the compound preparation ointment for the treatment of psoriasis vulgaris

[0073] (1) Weigh the following components by weight (g):

[0074] Clobetasol Propionate 8

[0075] All-trans retinoic acid 10

[0076] Polysorbate 80 900

[0077] Sorbitan Stearate 60 1500

[0078] Propyl gallate 60

[0079] 2,6-di-tert-butyl-p-cresol 20

[0080] Vitamin E 50

[0081] Citric acid 1

[0082] Propylene glycol 2000

[0083] Absolute ethanol 800

[0084] Lanolin 1800

[0085] Yellow Vaseline Increased to 20000

[0086] (2) Yellow petrolatum and lanolin were pretreated at 120°C for 2 hours, then the lanolin, polysorbate 80, sorbitan stearate 60 and yellow petrolatum were mixed and heated to 60°C to melt, and stirred well for later use;

[0087] (3) dissolve citric acid with propylene glycol, then dissolve propyl gallate, then add in (2) and stir and emulsify;

[0088] (4) Dissolve vitamin E and 2,6-di-tert-butyl-p-cresol with 700g of absolute ethanol...

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PUM

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Abstract

A medicine for treating psoriasis vulgaris contains clobetasol propionate and vitamin A acid. Its preparing process is also disclosed. Its advantages are high curativ effect, and low toxic by-effect.

Description

technical field [0001] The invention relates to a compound preparation and a preparation process thereof, in particular to a compound preparation comprising clobetasol propionate (CP) and tretinoin (RA) for treating psoriasis vulgaris and a preparation process thereof. Background technique [0002] Psoriasis is a common skin disease characterized by red papules or plaques covered with layers of silvery white scales. Currently, clobetasol propionate (CP) and retinoic acid (RA), which are routinely used clinically to treat psoriasis, are used alone. Clobetasol propionate (CP) is one of the most potent corticosteroids (CS) developed in the early 1970s, with vasoconstrictor activity and anti-inflammatory effects. Appropriate concentration of clobetasol propionate (CP) has the relatively optimal clinical curative effect, the strongest anti-inflammatory activity and the largest safety index. The mechanism of clobetasol propionate (CP) topical application involves inhibiting the ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61P17/06
Inventor 过建阳夏玲
Owner JIANGSU SEMPOLL PHARMA
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