Hollow fiber membrane for purifying blood and method for preparation thereof

A technology for blood purification and manufacturing methods, applied in chemical instruments and methods, membranes, membrane technology, etc., can solve the problems of no description of albumin dialysis performance, unclear correlation of dry membrane, performance degradation, etc.

Inactive Publication Date: 2004-11-03
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in order to prevent performance degradation due to drying, it is necessary to adsorb low-volatility organic liquids such as glycerin, and as a result, there is no change in the problem of containing soluble components in modules made of the obtained membranes.
Also, there is no description of the dialysis performance of substances with low permeability such as albumin
[0010] Also, JP-A-2000-300663 and JP-A-2001-205057 describe examples of manufacturing hollow wires without using a membrane pore retaining agent, but do not describe the dialysis performance of the obtained membranes. In these inventions, The technical relationship between the manufacturing method and the characteristics of the obtained dry film is not clear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] 18.0% by weight of polysulfone (P-1700 produced by U.S. Amoco Engineering Polymers), 4.3% by weight of polyvinylpyrrolidone (K90 produced by BASF, Germany, with a weight average molecular weight of 1,200,000) were dissolved in 77.7% by weight of N,N- Dimethylacetamide to make a homogeneous solution. Here, the mixing ratio of polyvinylpyrrolidone to polysulfone in the membrane-forming stock solution was 23.9% by weight. The film-making stock solution is kept at 60° C., and the internal liquid formed by a mixed solution of 30% by weight N, N-dimethylacetamide and 70% by weight of water is simultaneously fed from the spinning nozzle (double annular nozzle, 0.1mm-0.2 mm-0.3mm) is sprayed, passed through a gap of 0.96m, and immersed in a coagulation bath formed by water at 75°C.

[0091] At this time, the nozzle to the coagulation bath was surrounded by a cylindrical tube, nitrogen gas containing water vapor was made to flow in the tube, and the humidity in the tube was con...

Embodiment 2

[0098] The same operation as in Example 1 was carried out except that the polyvinylpyrrolidone in the film-forming stock solution was 4% by weight and the N,N-dimethylacetamide was 78% by weight. At this time, the mixing ratio of polyvinylpyrrolidone to polysulfone in the membrane-forming stock solution was 22.2% by weight. The properties of the film are shown in Table 1.

[0099] The amount of the membrane eluted from the membrane is extremely small, and the adsorption of blood proteins and platelets is small. In addition, the low permeation rate from albumin and the excellent clearance rate of β2-microglobulin also indicate that it is a membrane excellent in dialysis performance.

Embodiment 3

[0101] The same operation as in Example 1 was performed except that the polyvinylpyrrolidone in the film-forming stock solution was 4.8% by weight and the N,N-dimethylacetamide was 77.2% by weight. At this time, the mixing ratio of polyvinylpyrrolidone to polysulfone in the membrane-forming stock solution was 26.7% by weight. The properties of the film are shown in Table 1.

[0102] The amount of the membrane eluted from the membrane is extremely small, and the adsorption of blood proteins and platelets is small. In addition, since the permeation rate of albumin is small and the clearance rate of β2-microglobulin is excellent, it also shows that it is a membrane excellent in dialysis performance.

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Abstract

It is intended to provide a blood purification membrane having excellent performance and showing little elution of blood and little adhesion of blood proteins or platelets. The above object can be achieved by using a moisten membrane, which is free from any membrane pore-sustaining agent and has a high water permeation dose and a large pore size, and lessening the pore size by drying the membrane after desolvation.

Description

technical field [0001] The present invention relates to a high-performance blood purification membrane with extremely low elution from the membrane and excellent dialysis performance with little adsorption of blood proteins or platelets, and a method for producing the same. Background technique [0002] In recent years, the technology of using selective permeable membranes has made significant progress, and has now been applied to a wide range of applications such as gas or liquid separation membranes, hemodialyzers in the medical field, blood filters, and blood component selective separation membranes. field. [0003] As the material of the film, cellulose (regenerated cellulose, acetate cellulose, chemically modified cellulose, etc.), polyacrylonitrile, polymethacrylate, polysulfone, polyethylene vinyl, etc. Polymers such as alcohols and polyamides. [0004] Among them, polysulfone polymers have been attracting attention as semi-permeable membrane materials because of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16B01D67/00B01D69/02B01D69/08B01D71/68D01F6/76D01F6/94
CPCD01F6/94B01D69/02D01F6/76B01D67/0011B01D71/68B01D2323/12A61M1/16B01D67/0095B01D69/08B01D2323/385B01D2325/20B01D67/00111
Inventor 大石辉彦花井智司
Owner ASAHI KASEI MEDICAL CO LTD
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