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Methods of treating liver fibrosis and hepatitis C virus infection

A technology for liver fibrosis and hepatitis C virus, which can be used in antiviral agents, digestive systems, pharmaceutical formulations, etc., and can solve the problem of patients without treatment options.

Inactive Publication Date: 2005-01-12
INTERMUNE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date there are no effective treatment options for these patients

Method used

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Embodiment Construction

[0032] The invention provides a method for treating hepatitis C virus (HCV) infection; a method for treating liver fibrosis, including reducing clinical liver fibrosis, reducing the possibility of liver fibrosis, and reducing parameters related to liver fibrosis. The methods generally comprise administering to a subject in need thereof a therapeutically effective amount of IFN-alpha and IFN-gamma. The synergistic effect of this combination therapy was much higher than that of IFN-α and IFN-γ treatments alone. In many embodiments, treatment of humans is of particular interest.

[0033] Hepatic fibrosis is a precursor to complications associated with cirrhosis, such as portal hypertension, progressive hepatic insufficiency, and hepatocellular carcinoma. Reducing liver fibrosis may therefore reduce the incidence of such complications. Accordingly, the present invention further provides methods of reducing the likelihood of an individual developing complications associated with ...

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PUM

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Abstract

The present invention provides methods of reducing liver fibrosis; methods of increasing liver function in individuals with liver fibrosis; methods of reducing the incidence of complications associated with HCV and cirrhosis; methods of reducing viral load, and treatments Method of HCV Infection. These methods generally involve the simultaneous administration of therapeutically effective amounts of IFN-α and IFN-γ.

Description

field of invention [0001] The invention relates to the field of treatment of liver fibrosis and hepatitis C virus infection. Background of the invention [0002] Liver fibrosis can be induced by chronic toxic damage to the liver, such as hepatitis C virus (HCV) infection, autoimmune injury, and long-term exposure to poisons such as alcohol. Chronic toxic injury leads to repeated cycles of hepatocellular injury and repair with chronic inflammation. Over variable periods of time, abnormal extracellular matrix accumulates progressively as a result of the host's repair response to wounding. If left unchecked, this leads to increased deposition of fibrous material to the point where the liver's architecture becomes distorted and jeopardizes the liver's ability to regenerate. The progressive accumulation of scar tissue in the liver eventually leads to the histopathologically depicted cirrhosis, defined as the formation of fibrous septa throughout the liver with micronodular form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61P1/16A61P31/14
CPCA61K38/212A61K38/217A61P1/16A61P31/12A61P31/14A61P31/20A61K2300/00A61K38/21
Inventor H·H·许
Owner INTERMUNE INC