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Pharmaceutical use of Resina-Ferulae extract

A technology of extracts and uses, applied in the direction of medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve problems such as drug dependence, side effects, poisoning, etc.

Inactive Publication Date: 2005-02-16
王彦丁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs are also narcotic drugs or psychotropic drugs, which can cause drug dependence, so they are also a kind of drug, and long-term use can cause poisoning and bring many side effects

Method used

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  • Pharmaceutical use of Resina-Ferulae extract
  • Pharmaceutical use of Resina-Ferulae extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] The Ferulicum extract of the present invention is used to prepare a drug for detoxification: Ferulic injection, which is prepared by conventional methods.

[0074] Ferulicum ferulae extract is prepared from Xinjiang ferulicum or Fukang ferulicum by the usual steam distillation method. Measured in parts by weight, take 0.1-20 parts of Xinjiang Ferulicum or Fukang Ferulicum, add 0.1-80 parts of purified water, carry out steam distillation, control the temperature at 105.5-108 ° C, collect 0.2-400 parts of the first distillate, and then Perform redistillation and collect 0.1 to 200 parts of the distillate, which is the Ferulicum extract. Ferulicum extract is a milky white liquid, a supersaturated solution of volatile oil, with a pH value of 4-5.7. Sent to the Analysis and Testing Center of the Chinese Academy of Sciences, and detected by GC-MS, it mainly contains: α-pinene, α-terpinene, 2-borneol, terpineol 4-ol, D-feulyl alcohol, pincarveol, β-ocimene A, β-ocimene B, di...

Embodiment 2

[0079] The Ferulicum extract of the present invention is used to prepare a drug for detoxification: Ferulic injection, which is prepared by conventional methods.

[0080] Ferulicum extract is prepared by the usual azeotropic distillation method. Take 1,000g of Xinjiang Ferulicum or Fukang Ferulicum, add 16,000ml of purified water, control the temperature at 105-108°C for azeotropic distillation, collect 8,000ml of initial distillate, and then carry out redistillation, and collect about 2,000ml of heavy distillate, which is Ferulicum extract . Physicochemical property and main component of Ferulicum extract are identical with embodiment 1.

[0081]Add 5g of polysorbate 80 (for medicinal use) to 1000ml of Ferulicum extract, stir for 5min, add 7g of sodium chloride (for injection), then add water for injection to 1000ml, continue stirring for 5min, and pass through a micrometer of 0.22μm Membrane filtration, filling and sealing of 2ml ampoules, and sterilizing at 100°C for 30 m...

Embodiment 3

[0083] The ferulicum extract is used to prepare a kind of detoxification drug: the ferulic injection, which is prepared by a conventional method.

[0084] Ferulicum extract is prepared by the usual negative pressure distillation method. Take 500g of Xinjiang Ferulicum or Fukang Ferulicum, add 8000ml of purified water, control the conditions at 105-108°C / 1300-1400Pa, carry out negative pressure distillation, collect 4000ml of the initial distillate, and then carry out redistillation, and collect the redistillate that is Wei extract 1000ml. Physicochemical property and main component of Ferulicum extract are identical with embodiment 1.

[0085] Add 5g of polysorbate 80 (medicinal) to 1000ml of Ferulicum extract, stir for 5min, add 7g of sodium chloride (for injection), add water for injection to 1000ml, continue stirring for 5min, filter through 0.22μm micromembrane After that, fill and seal the ampoules, and sterilize at 100°C for 30 minutes to obtain Ferulic Injection. The...

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Abstract

The invention is a medicine producing use of asafetida extract, which relates to the use of extract of Chinese medicine asafetida. The asafetida extract is used to produce drug-breaking medicine. The drug-breaking medicine can be injection, pill dropping agent, tablet, particles, powder, oral liquid. The asafetida extract includes alpha-pinene, alpha-terpinenes, 2-borneol, terpine 4-alcohol, D-fenchyl alcohol, pinocarveol, beta-ocimene A, beta-ocimene B, di-secondary butyl disulfide, secondary butyl-antiform-1-butenyl disulfide, secondary butyl-synform-1-butyl-disulfide, secondary butyl-synform-propenyl disulfide, secondary butyl-antiform-2-butenyl disulfide, sulph-secondary butyl-antiform-methyl ethane disulfide. It uses xinjiang asafetida or fukang asafetida oil glue resin to produce with normal method.

Description

technical field [0001] The invention relates to the use of the extract of the traditional Chinese medicine Ferulicum ferulae in preparing a detoxification drug. Background technique [0002] Asafoetida is a natural plant secretion. "Pharmacopoeia of the People's Republic of China" 2000 edition one 148 pages records: Ferulica is bitter, pungent and warm in nature and belongs to the spleen and stomach meridians. Dispelling stagnation, dispelling cold, killing parasites, used for stagnation of meat, congestion, mass in the abdomen, abdominal pain caused by parasites. "National Compilation of Chinese Herbal Medicine" Volume 2 People's Health Publishing House, 1978, page 318 records: Ferulicum is pungent in nature and slightly warm. Dispelling stagnation, killing insects, dispelling cold. Indications for insect accumulation, abdominal mass, abdominal distension, malaria, dysentery, and prevention of measles. The traditional use of asafoetida is decocting in water and making in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/10A61P25/36
Inventor 王泽民
Owner 王彦丁
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