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Application of gold ear mycelium polysaccharide for lowering blood fat and blood sugar

A technology of mycelium polysaccharides and golden fungus, applied in the field of application of golden fungus polysaccharides in reducing blood sugar and blood lipids, can solve problems such as difficult extraction, no commercial value, and difficult practical application

Inactive Publication Date: 2005-06-08
HEHAI TECHNOLOGY ENGINEERING GROUP CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of further in-depth research, the applicant of the present invention has made considerable progress in the understanding of the pharmacological effects of Auricularia polysaccharides, and found that it has certain curative effects on many aspects such as lowering liver cholesterol, enhancing immunity, promoting hematopoietic function, and anti-aging. , especially confirmed by experiments, the polysaccharides from Temelle aurantiabla mycelium (Polysaccharides from Temelle aurantiabla mycelium, TMP) extracted from fermented mycelia have significant hypoglycemic effect (although the polysaccharides of the fruit body of the golden ear also have similar effect, but its yield Low, difficult to extract, so no commercial value, difficult to practical application)

Method used

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  • Application of gold ear mycelium polysaccharide for lowering blood fat and blood sugar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Materials used in this embodiment are as follows:

[0011] 1. Auricularia mycelium polysaccharide: prepared by laboratory fermentation and extraction according to the attached steps A-G.

[0012] 2. Animals: male SD rats, weighing 190-210 g (certificate number of experimental animals: Shanghai Donghe Zhengzi No. 152).

[0013] 3. Drugs: Alloxan, Jiangtangling Tablets, Baitangping, Anthrone, Concentrated Sulfuric Acid, Potassium Hydroxide, Sodium Chloride, n-Butanol, Chloroform and other domestic analytical pure reagents.

[0014] 4. Kits: Glucose Enzymatic Determination Kit, Enzymatic Serum (Syrup) Triglyceride Kit, Serum (Syrup) Enzymatic Total Cholesterol Determination Kit.

[0015] 5. Instruments: 722-type spectrophotometer, vortex mixer, high-speed desktop centrifuge, portable high-pressure steam sterilizer, homogenizer, high-speed refrigerated centrifuge, constant temperature water bath, rotary shaker, 10-liter fermentation tank.

[0016] The above steps of ferme...

Embodiment 2

[0049] This example uses the same materials as in Example 1, and the steps of fermenting, culturing and extracting the polysaccharides of Auricularia auricosa mycelium are also the same as in Example 1, the difference is that this example measures the effect of TMP on alloxan-induced hyperglycemia before and after administration. Effects of Plasma Cholesterol and Triglyceride Levels in Rats

[0050] The effect of TMP on lipid metabolism in rats with hyperglycemia induced by alloxan, see Table 2

[0051] Table 2: Effect of TMP on alloxan-induced hyperglycemia rat plasma

[0052] Effect of Cholesterol and Triglyceride Levels

[0053] Group Number of Rats Dose Plasma Cholesterol Plasma Triglycerides

[0054] (mg / kg) (mmol / L) (mmol / L)

[0055] Group Number Dose cholesterol triglyceride

[0056] I 8 Normal saline 2.079±0.528 0.961±0.565

[0057] II 8 100 1.984±0.47 0.456±0.108 *

[0058] III 8 20 1.718±0.451 0.509±0.264

[0059]...

Embodiment 3

[0070] Adopt the following method to prepare golden ear mycelia polysaccharide:

[0071] A. Put the tank - put the cultured fermenter into the centrifuge, centrifuge, take out the mycelium, wash with water and spin dry;

[0072] B. Cooking - adding pure water to the mycelium, boiling, and drying with a centrifuge;

[0073] C. Hydrolysis - combine the cooking liquid and add KOH for hydrolysis;

[0074] D. Centrifugation——separate the hydrolyzate and get the superfluid;

[0075] E. Ultrafiltration—Use a 0.1 micron membrane for microfiltration, and then use a membrane with a molecular weight of 5000 for ultrafiltration;

[0076] F. Concentration - Concentrate the ultrafiltrate with alcohol to make it precipitate;

[0077] G. Crystallization - filter out the concentrated precipitate, wash with concentrated alcohol and then dry to obtain the polysaccharide of Auricularia mycelium;

[0078] Then make an aqueous solution, heat to dissolve, and mix evenly, then pack into an inject...

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Abstract

An application of the Golden mushroom's mycelial polyose in preparing the medicines for decreasing blood fat and blood sugar with high effect is disclosed.

Description

technical field [0001] The invention relates to a new application of auricularia mycelium polysaccharide, in particular to the application of the auricularia mycelium polysaccharide in lowering blood sugar and lowering blood fat. Background technique [0002] Diabetes and hyperlipidemia are common diseases and frequently-occurring diseases of middle-aged and elderly people at present. The induced diseases caused by diabetes and hyperlipidemia seriously endanger people's life and health. Existing Western medicines for lowering blood sugar and blood lipids inevitably have side effects, while traditional Chinese medicines for lowering blood sugar and blood fats are generally not effective enough. [0003] Golden ear is a well-known edible and medicinal fungus in Basidiomycetes and Tremellaceae. It is mainly produced in the deep mountains of Yunnan, Guizhou and other places in my country. Although its medicinal value has been recognized by people for a long time, it has always b...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P3/10
Inventor 俞建国瞿伟菁张志才
Owner HEHAI TECHNOLOGY ENGINEERING GROUP CO LTD
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