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Chinese traditional medicine compound injection and preparation method thereof

The invention relates to a compound injection and a technology for its preparation process, which are applied to a traditional Chinese medicine compound injection and its preparation process. The preparation of the injection is in the field of compound preparations for anti-hepatitis and liver fibrosis. , the exact effect of curative effect

Inactive Publication Date: 2005-07-06
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chronic hepatitis caused by hepatitis B and C virus, because there is still a lack of effective antiviral drugs, the focus of treatment is still to reduce liver lesions, promote liver cell regeneration, restore liver function, and prevent or treat liver fibrous tissue hyperplasia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 (injection): get 120g Panax notoginseng saponins and 150g ammonium glycyrrhizinate (monoammonium salt or diammonium salt), add appropriate amount of water for injection and stir and make it dissolve by heating in a water bath at 60°C, add 5% Na 2 CO 3 Adjust the pH of the solution to 6.5-8.0, add 0.1% activated carbon, heat and boil for 15 minutes for decolorization and depyrogenation, filter after cooling slightly, add water for injection to the full volume of 5000ml, filter with a microporous membrane, melt seal in a 5ml ampoule, Sterilize by autoclaving at 105°C.

Embodiment 2

[0014] Example 2 (large-capacity injection): Take 12g Panax notoginseng saponins, 15g ammonium glycyrrhizinate (monoammonium salt or diammonium salt) and 65g sodium chloride, add an appropriate amount of water for injection, stir and heat it in a water bath at 60°C to dissolve it , with 5% Na 2 CO 3 Adjust the pH of the solution to 6.5-8.0, add 0.1% activated carbon, heat and boil for 15 minutes to decolorize and remove pyrogens, filter after cooling down slightly, add water for injection to the full amount of 10000ml, filter through a microporous membrane, and pack in 100ml infusion In the bottle, sterilize by autoclaving at 105°C.

Embodiment 3

[0015] Example 3 (freeze-dried powder injection): Take 120g Panax notoginseng saponins, 150g ammonium glycyrrhizinate (monoammonium salt or diammonium salt) and 180g mannitol, add appropriate amount of water for injection, stir and heat in a water bath at 60°C to dissolve , with 5% Na 2 CO 3 Adjust the pH of the solution to 6.5-8.0, add 0.1% activated carbon, heat and boil for 15 minutes to decolorize and remove pyrogens, filter after cooling slightly, add water for injection to the full amount of 2500ml, filter with a microporous membrane, and pack in vials, Each bottle contains 2.5ml. Freeze-drying conditions: pre-freezing temperature -50°C, pre-freezing time 3 hours; sublimation temperature -25°C, sublimation time 10 hours; first drying temperature 20°C, drying time 4 hours; second drying temperature 40°C, dry Time 6 to 8 hours, that is.

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PUM

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Abstract

The invention provides a Chinese traditional medicine compound injection and preparation method, wherein the compound comprises Notoginsen triterpenes, ammonium glycyrrhizinato, sodium chloride, glucose, mannitol, lactose, sorbitol, dextran as the clinically accept, osmoregulation agent, freeze drying excipient and water for injection. The components can be prepared into injection, high volume injection and freeze dried injection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine compound injection containing Panax notoginseng saponins and ammonium glycyrrhizinate (monoammonium salt or diammonium salt) and a preparation process thereof. [0002] It relates to a traditional Chinese medicine compound injection for treating hepatitis and liver fibrosis, including injection, large-capacity injection, freeze-dried powder injection, etc., and the route of administration is intravenous injection. In particular, it relates to a compound preparation for anti-hepatitis and liver fibrosis formed by the effective extracts of natural medicines, and the invention also relates to a preparation method of the injection. Background technique [0003] China is a country with a large population, but also a "big hepatitis country". According to the national viral hepatitis epidemiological survey in 1992, 600 million people in China have been i...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K31/704A61P1/16A61P31/14
Inventor 唐星王蕾张倩
Owner SHENYANG PHARMA UNIVERSITY
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